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Human leukocyte antigen class II molecules confer both susceptibility and progression in Japanese patients with primary biliary cirrhosis
http://hdl.handle.net/10091/00019822
http://hdl.handle.net/10091/00019822a984ade1-1e2b-4b52-8a8c-bb3a790451ee
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
Human_leukocyte_antigen_class_II_molecules_confer_both_susceptibility.pdf (502.6 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2017-09-20 | |||||
| タイトル | ||||||
| タイトル | Human leukocyte antigen class II molecules confer both susceptibility and progression in Japanese patients with primary biliary cirrhosis | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1002/hep.24705 | |||||
| 関連名称 | 10.1002/hep.24705 | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Umemura, Takeji
× Umemura, Takeji× Joshita, Satoru× Ichijo, Tetsuya× Yoshizawa, Kaname× Katsuyama, Yoshihiko× Tanaka, Eiji× Ota, Masao |
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| 信州大学研究者総覧へのリンク | ||||||
| 表示名 | Umemura, Takeji | |||||
| URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.ymSpgpkh.html | |||||
| 信州大学研究者総覧へのリンク | ||||||
| 表示名 | Joshita, Satoru | |||||
| URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.PeLNbVym.html | |||||
| 信州大学研究者総覧へのリンク | ||||||
| 表示名 | Tanaka, Eiji | |||||
| URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.HFDCHekh.html | |||||
| 信州大学研究者総覧へのリンク | ||||||
| 表示名 | Ota, Masao | |||||
| URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.ZefVOFkh.html | |||||
| 出版者 | ||||||
| 出版者 | WILEY-BLACKWELL | |||||
| 引用 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | HEPATOLOGY. 55(2):506-511 (2012) | |||||
| 書誌情報 |
HEPATOLOGY 巻 55, 号 2, p. 506-511, 発行日 2012-02 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Along with twin and family studies, recent genome-wide association studies suggest that genetic factors contribute to the susceptibility and severity of primary biliary cirrhosis (PBC). Although several reports have demonstrated that the human leukocyte antigen (HLA) DRB1*08:03 allele is associated with disease susceptibility in Japan, the precise analysis of HLA haplotypes and the role of amino acid alignment have not been fully clarified. We investigated HLA class I A, B, and C and HLA class II DRB1 and DQB1 alleles and haplotypes in 229 Japanese patients with PBC and compared them with the published data of 523 healthy subjects. Significant associations were found with PBC susceptibility for the DRB1*08:03-DQB1*06:01 (13% versus 6%; P = 0.000025; odds ratio [OR] = 2.22) and DRB1*04:05-DQB1*04:01 haplotypes (17% versus 13%; P = 0.044; OR = 1.38). Conversely, there were significant protective associations with the DRB1*13:02-DQB1*06:04 (2% versus 5%; P = 0.00093; OR = 0.27) and DRB1*11:01-DQB1*03:01 haplotypes (1% versus 4%; P = 0.03; OR = 0.37). The frequency of the DRB1*09:01-DQB1*03:03 haplotype was significantly higher in patients who had received orthotopic liver transplantation (33% versus 11%; P = 0.0012; OR = 3.96). Furthermore, the frequency of serine at position 57 (P = 0.0000015; OR = 1.83) of the DR beta chain differed the most in patients with PBC, compared with healthy subjects. Conclusion: This study established the role of HLA haplotypes in determining PBC susceptibility and progression in the Japanese population. Further resequencing of the HLA region is required to more precisely identify the genetic components of PBC. (HEPATOLOGY 2012) | |||||
| 資源タイプ（コンテンツの種類） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Article | |||||
| ISSN | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 0270-9139 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA10620324 | |||||
| PubMed | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | https://pubmed.ncbi.nlm.nih.gov/21953406 | |||||
| 関連名称 | 21953406 | |||||
| 権利 | ||||||
| 権利情報 | This is the peer reviewed version of the following article: Umemura, T., Joshita, S., Ichijo, T., Yoshizawa, K., Katsuyama, Y., Tanaka, E., Ota, M. and The Shinshu PBC Study Group (2012), Human leukocyte antigen class II molecules confer both susceptibility and progression in Japanese patients with primary biliary cirrhosis. Hepatology, 55: 506–51, which has been published in final form at https://doi.org/10.1002/hep.24705 . This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. | |||||
| 出版タイプ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| WoS | ||||||
| 表示名 | Web of Science | |||||
| URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000299632900019 | |||||
