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  1. 050 医学部, 大学院医学系研究科
  2. 0501 学術論文

Human leukocyte antigen class II molecules confer both susceptibility and progression in Japanese patients with primary biliary cirrhosis

http://hdl.handle.net/10091/00019822
a984ade1-1e2b-4b52-8a8c-bb3a790451ee
名前 / ファイル ライセンス アクション
Human_leukocyte_antigen_class_II_molecules_confer_both_susceptibility.pdf Human_leukocyte_antigen_class_II_molecules_confer_both_susceptibility.pdf (502.6 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2017-09-20
タイトル
言語 en
タイトル Human leukocyte antigen class II molecules confer both susceptibility and progression in Japanese patients with primary biliary cirrhosis
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Umemura, Takeji

× Umemura, Takeji

WEKO 103921

en Umemura, Takeji

Search repository
Joshita, Satoru

× Joshita, Satoru

WEKO 103953

en Joshita, Satoru

Search repository
Ichijo, Tetsuya

× Ichijo, Tetsuya

WEKO 103954

en Ichijo, Tetsuya

Search repository
Yoshizawa, Kaname

× Yoshizawa, Kaname

WEKO 103955

en Yoshizawa, Kaname

Search repository
Katsuyama, Yoshihiko

× Katsuyama, Yoshihiko

WEKO 103956

en Katsuyama, Yoshihiko

Search repository
Tanaka, Eiji

× Tanaka, Eiji

WEKO 103957

en Tanaka, Eiji

Search repository
Ota, Masao

× Ota, Masao

WEKO 103958

en Ota, Masao

Search repository
信州大学研究者総覧へのリンク
氏名 Umemura, Takeji
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.ymSpgpkh.html
信州大学研究者総覧へのリンク
氏名 Joshita, Satoru
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.PeLNbVym.html
信州大学研究者総覧へのリンク
氏名 Tanaka, Eiji
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.HFDCHekh.html
信州大学研究者総覧へのリンク
氏名 Ota, Masao
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.ZefVOFkh.html
出版者
出版者 WILEY-BLACKWELL
引用
内容記述タイプ Other
内容記述 HEPATOLOGY. 55(2):506-511 (2012)
書誌情報 HEPATOLOGY

巻 55, 号 2, p. 506-511, 発行日 2012-02
抄録
内容記述タイプ Abstract
内容記述 Along with twin and family studies, recent genome-wide association studies suggest that genetic factors contribute to the susceptibility and severity of primary biliary cirrhosis (PBC). Although several reports have demonstrated that the human leukocyte antigen (HLA) DRB1*08:03 allele is associated with disease susceptibility in Japan, the precise analysis of HLA haplotypes and the role of amino acid alignment have not been fully clarified. We investigated HLA class I A, B, and C and HLA class II DRB1 and DQB1 alleles and haplotypes in 229 Japanese patients with PBC and compared them with the published data of 523 healthy subjects. Significant associations were found with PBC susceptibility for the DRB1*08:03-DQB1*06:01 (13% versus 6%; P = 0.000025; odds ratio [OR] = 2.22) and DRB1*04:05-DQB1*04:01 haplotypes (17% versus 13%; P = 0.044; OR = 1.38). Conversely, there were significant protective associations with the DRB1*13:02-DQB1*06:04 (2% versus 5%; P = 0.00093; OR = 0.27) and DRB1*11:01-DQB1*03:01 haplotypes (1% versus 4%; P = 0.03; OR = 0.37). The frequency of the DRB1*09:01-DQB1*03:03 haplotype was significantly higher in patients who had received orthotopic liver transplantation (33% versus 11%; P = 0.0012; OR = 3.96). Furthermore, the frequency of serine at position 57 (P = 0.0000015; OR = 1.83) of the DR beta chain differed the most in patients with PBC, compared with healthy subjects. Conclusion: This study established the role of HLA haplotypes in determining PBC susceptibility and progression in the Japanese population. Further resequencing of the HLA region is required to more precisely identify the genetic components of PBC. (HEPATOLOGY 2012)
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Article
ISSN
収録物識別子タイプ PISSN
収録物識別子 0270-9139
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA10620324
PubMed
関連識別子
識別子タイプ PMID
関連識別子 https://pubmed.ncbi.nlm.nih.gov/21953406
関連名称
関連名称 21953406
DOI
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1002/hep.24705
関連名称
関連名称 10.1002/hep.24705
権利
権利情報 This is the peer reviewed version of the following article: Umemura, T., Joshita, S., Ichijo, T., Yoshizawa, K., Katsuyama, Y., Tanaka, E., Ota, M. and The Shinshu PBC Study Group (2012), Human leukocyte antigen class II molecules confer both susceptibility and progression in Japanese patients with primary biliary cirrhosis. Hepatology, 55: 506–51, which has been published in final form at https://doi.org/10.1002/hep.24705 . This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
WoS
表示名 Web of Science
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000299632900019
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