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Diversity and Complexity of the Mouse Saa1 and Saa2 genes
http://hdl.handle.net/10091/00019826
http://hdl.handle.net/10091/00019826d08036cb-19a2-4d95-9b93-c0c1c078591e
名前 / ファイル | ライセンス | アクション |
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Diversity_and_Complexity_of_the_Mouse_Saa1_and_Saa2_genes.pdf (1.8 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-09-20 | |||||
タイトル | ||||||
タイトル | Diversity and Complexity of the Mouse Saa1 and Saa2 genes | |||||
言語 | en | |||||
言語 | ||||||
言語 | eng | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1538/expanim.63.99 | |||||
関連名称 | 10.1538/expanim.63.99 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | gene conversion | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | gene duplication | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Mus subspecies | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | polymorphism | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | serum amyloid A | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Mori, Masayuki
× Mori, Masayuki× Tian, Geng× Ishikawa, Akira× Higuchi, Keiichi |
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信州大学研究者総覧へのリンク | ||||||
表示名 | Mori, Masayuki | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.OpSCZafV.html | |||||
信州大学研究者総覧へのリンク | ||||||
表示名 | Higuchi, Keiichi | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.gCfUPmAh.html | |||||
出版者 | ||||||
出版者 | INT PRESS EDITING CENTRE INC | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | EXPERIMENTAL ANIMALS. 63(1):99-106 (2014) | |||||
書誌情報 |
EXPERIMENTAL ANIMALS 巻 63, 号 1, p. 99-106, 発行日 2014-01 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Mouse strains show polynnorphisms in the amino acid sequences of serum amyloid A 1 (SAA1) and serum amyloid A 2 (SAA2). Major laboratory mouse strains are classified based on the sequence as carrying the A haplotype (e.g., BALB/c) or B haplotype (e.g., SJL/J) of the Seal and Saa2 gene unit. We attempted to elucidate the diversity of the mouse Saa1 and Saa2 family genes at the nucleotide sequence level by a systematic survey of 6 inbred mouse strains from 4 Mus subspecies, including Mus musculus domesticus, Mus musculus musculus, Mus musculus castaneus, and Mus spretus. Saa1 and Saa2 genes were obtained from the mouse genome by PCR amplification, and each full-length nucleotide sequence was determined. We found that Mus musculus castaneus mice uniquely possess 2 divergent Saa1 genes linked on chromosome 7. Overall, the mouse strains had distinct composite patterns of amino acid substitutions at 9 positions in SAA1 and SAA2 isoforms. The mouse strains also had distinct composite patterns of 2 polymorphic upstream regulatory elements that influenced gene transcription in in vitro reporter assays. B haplotype mice were revealed to possess an LTR insertion in the downstream region of Saa1. Collectively, these results indicate that the mouse Saa genes hold broader diversity and greater complexity than previously known, and these characteristics were likely attained through gene duplication and repeated gene conversion events in the Mus lineage. | |||||
資源タイプ(コンテンツの種類) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article | |||||
ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 1341-1357 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA11032321 | |||||
PubMed | ||||||
識別子タイプ | PMID | |||||
関連識別子 | https://pubmed.ncbi.nlm.nih.gov/24521869 | |||||
関連名称 | 24521869 | |||||
権利 | ||||||
権利情報 | © 2014 Japanese Association for Laboratory Animal Science | |||||
出版タイプ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
WoS | ||||||
表示名 | Web of Science | |||||
URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000330207200012 |