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  1. 050 医学部, 大学院医学系研究科
  2. 0501 学術論文

Diversity and Complexity of the Mouse Saa1 and Saa2 genes

http://hdl.handle.net/10091/00019826
http://hdl.handle.net/10091/00019826
d08036cb-19a2-4d95-9b93-c0c1c078591e
名前 / ファイル ライセンス アクション
Diversity_and_Complexity_of_the_Mouse_Saa1_and_Saa2_genes.pdf Diversity_and_Complexity_of_the_Mouse_Saa1_and_Saa2_genes.pdf (1.8 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2017-09-20
タイトル
言語 en
タイトル Diversity and Complexity of the Mouse Saa1 and Saa2 genes
言語
言語 eng
キーワード
主題Scheme Other
主題 gene conversion
キーワード
主題Scheme Other
主題 gene duplication
キーワード
主題Scheme Other
主題 Mus subspecies
キーワード
主題Scheme Other
主題 polymorphism
キーワード
主題Scheme Other
主題 serum amyloid A
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Mori, Masayuki

× Mori, Masayuki

WEKO 103925

en Mori, Masayuki

Search repository
Tian, Geng

× Tian, Geng

WEKO 103973

en Tian, Geng

Search repository
Ishikawa, Akira

× Ishikawa, Akira

WEKO 103974

en Ishikawa, Akira

Search repository
Higuchi, Keiichi

× Higuchi, Keiichi

WEKO 103975

en Higuchi, Keiichi

Search repository
信州大学研究者総覧へのリンク
氏名 Mori, Masayuki
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.OpSCZafV.html
信州大学研究者総覧へのリンク
氏名 Higuchi, Keiichi
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.gCfUPmAh.html
出版者
出版者 INT PRESS EDITING CENTRE INC
引用
内容記述タイプ Other
内容記述 EXPERIMENTAL ANIMALS. 63(1):99-106 (2014)
書誌情報 EXPERIMENTAL ANIMALS

巻 63, 号 1, p. 99-106, 発行日 2014-01
抄録
内容記述タイプ Abstract
内容記述 Mouse strains show polynnorphisms in the amino acid sequences of serum amyloid A 1 (SAA1) and serum amyloid A 2 (SAA2). Major laboratory mouse strains are classified based on the sequence as carrying the A haplotype (e.g., BALB/c) or B haplotype (e.g., SJL/J) of the Seal and Saa2 gene unit. We attempted to elucidate the diversity of the mouse Saa1 and Saa2 family genes at the nucleotide sequence level by a systematic survey of 6 inbred mouse strains from 4 Mus subspecies, including Mus musculus domesticus, Mus musculus musculus, Mus musculus castaneus, and Mus spretus. Saa1 and Saa2 genes were obtained from the mouse genome by PCR amplification, and each full-length nucleotide sequence was determined. We found that Mus musculus castaneus mice uniquely possess 2 divergent Saa1 genes linked on chromosome 7. Overall, the mouse strains had distinct composite patterns of amino acid substitutions at 9 positions in SAA1 and SAA2 isoforms. The mouse strains also had distinct composite patterns of 2 polymorphic upstream regulatory elements that influenced gene transcription in in vitro reporter assays. B haplotype mice were revealed to possess an LTR insertion in the downstream region of Saa1. Collectively, these results indicate that the mouse Saa genes hold broader diversity and greater complexity than previously known, and these characteristics were likely attained through gene duplication and repeated gene conversion events in the Mus lineage.
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Article
ISSN
収録物識別子タイプ PISSN
収録物識別子 1341-1357
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA11032321
PubMed
識別子タイプ PMID
関連識別子 https://pubmed.ncbi.nlm.nih.gov/24521869
関連名称 24521869
DOI
識別子タイプ DOI
関連識別子 https://doi.org/10.1538/expanim.63.99
関連名称 10.1538/expanim.63.99
権利
権利情報 © 2014 Japanese Association for Laboratory Animal Science
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
WoS
表示名 Web of Science
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000330207200012
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