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  1. 050 医学部, 大学院医学系研究科
  2. 0501 学術論文

Induction of LYVE-1/stabilin-2-positive liver sinusoidal endothelial-like cells from embryoid bodies by modulation of adrenomedullin-RAMP2 signaling

http://hdl.handle.net/10091/00020096
http://hdl.handle.net/10091/00020096
da035a60-b2d0-497e-a9b9-f55dd6505dbe
名前 / ファイル ライセンス アクション
Induction_of_LYVE-1_stabilin-2-positive_liver_sinusoidal_endothelial-like_cells.pdf Induction_of_LYVE-1_stabilin-2-positive_liver_sinusoidal_endothelial-like_cells.pdf (5.8 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2017-12-25
タイトル
タイトル Induction of LYVE-1/stabilin-2-positive liver sinusoidal endothelial-like cells from embryoid bodies by modulation of adrenomedullin-RAMP2 signaling
言語
言語 eng
DOI
関連識別子 https://doi.org/10.1016/j.peptides.2011.07.005
関連名称 10.1016/j.peptides.2011.07.005
キーワード
主題 Adrenomedullin (AM), Receptor activity-modifying protein (RAMP), Lymphatic vessel endothelial hyaluronan receptor-1 (LYVE-1), Stabilin-2, Liver sinusoidal endothelial cells (LSEC), Embryonic stem cells
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Arai, Takuma

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Sakurai, Takayuki

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Kamiyoshi, Akiko

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Ichikawa-Shindo, Yuka

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Iinuma, Nobuyoshi

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Iesato, Yasuhiro

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Koyama, Teruhide

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Yoshizawa, Takahiro

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Uetake, Ryuichi

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Yamauchi, Akihiro

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Yang, Lei

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Kawate, Hisaka

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Ogawa, Shinichiro

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Kobayashi, Akira

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Miyagawa, Shinichi

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Shindo, Takayuki

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信州大学研究者総覧へのリンク
氏名 Sakurai, Takayuki
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.jaLUuNkh.html
信州大学研究者総覧へのリンク
氏名 Kamiyoshi, Akiko
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.OpLVuNkh.html
信州大学研究者総覧へのリンク
氏名 Iesato, Yasuhiro
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.gpDmbVym.html
信州大学研究者総覧へのリンク
氏名 Yoshizawa, Takahiro
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.OCyUumkh.html
信州大学研究者総覧へのリンク
氏名 Ogawa, Shinichiro
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.PmnhOayC.html
信州大学研究者総覧へのリンク
氏名 Shindo, Takayuki
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.OCLpOayV.html
出版者
出版者 ELSEVIER SCIENCE INC
引用
内容記述 PEPTIDES. 32(9):1855-1865 (2011)
書誌情報 PEPTIDES

巻 32, 号 9, p. 1855-1865, 発行日 2011-09
抄録
内容記述 Embryonic stem cells (ESCs) are a useful source for various cell lineages. So far, however, progress toward reconstitution of mature liver morphology and function has been limited. We have shown that knockout mice deficient in adrenomedullin (AM), a multifunctional endogenous peptide, or its receptor-activity modifying protein (RAMP2) die in utero due to poor vascular development and hemorrhage within the liver. In this study, using embryoid bodies (EBs)-culture system, we successfully induced liver sinusoidal endothelial-like cells by modulation of AM-RAMP2. In an EB differentiation system, we found that co-administration of AM and SB431542, an inhibitor of transforming growth factor beta (TGF beta) receptor type 1, markedly enhanced differentiation of lymphatic vessel endothelial hyaluronan receptor-1 (LYVE-1)/stabilin-2-positive endothelial cells. These cells showed robust endocytosis of acetylated low-density lipoprotein (Ac-LDL) and upregulated expression of liver sinusoidal endothelial cells (LSECs)-specific markers, including factor 8 (F8), Fc-gamma receptor 2b (Fcgr2b), and mannose receptor C type 1 (Mrc1), and also possessed fenestrae-like structure, a key morphological feature of LSECs. In RAMP2-null liver, by contrast, LYVE-1 was downregulated in LSECs, and the sinusoidal structure was disrupted. Our findings highlight the importance of AM-RAMP2 signaling for development of LSECs. (C) 2011 Elsevier Inc. All rights reserved.
資源タイプ(コンテンツの種類)
ISSN
収録物識別子タイプ PISSN
収録物識別子 0196-9781
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA10617807
PubMed
識別子タイプ PMID
関連識別子 https://pubmed.ncbi.nlm.nih.gov/21782867
関連名称 21782867
権利
権利情報 © 2011. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
WoS
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000295767400011
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