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Induction of LYVE-1/stabilin-2-positive liver sinusoidal endothelial-like cells from embryoid bodies by modulation of adrenomedullin-RAMP2 signaling
http://hdl.handle.net/10091/00020096
http://hdl.handle.net/10091/00020096da035a60-b2d0-497e-a9b9-f55dd6505dbe
名前 / ファイル | ライセンス | アクション |
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-12-25 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Induction of LYVE-1/stabilin-2-positive liver sinusoidal endothelial-like cells from embryoid bodies by modulation of adrenomedullin-RAMP2 signaling | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Adrenomedullin (AM) | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Receptor activity-modifying protein (RAMP) | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Lymphatic vessel endothelial hyaluronan receptor-1 (LYVE-1) | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Stabilin-2 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Liver sinusoidal endothelial cells (LSEC) | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Embryonic stem cells | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Arai, Takuma
× Arai, Takuma× Sakurai, Takayuki× Kamiyoshi, Akiko× Ichikawa-Shindo, Yuka× Iinuma, Nobuyoshi× Iesato, Yasuhiro× Koyama, Teruhide× Yoshizawa, Takahiro× Uetake, Ryuichi× Yamauchi, Akihiro× Yang, Lei× Kawate, Hisaka× Ogawa, Shinichiro× Kobayashi, Akira× Miyagawa, Shinichi× Shindo, Takayuki |
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信州大学研究者総覧へのリンク | ||||||
氏名 | Sakurai, Takayuki | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.jaLUuNkh.html | |||||
信州大学研究者総覧へのリンク | ||||||
氏名 | Kamiyoshi, Akiko | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.OpLVuNkh.html | |||||
信州大学研究者総覧へのリンク | ||||||
氏名 | Iesato, Yasuhiro | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.gpDmbVym.html | |||||
信州大学研究者総覧へのリンク | ||||||
氏名 | Yoshizawa, Takahiro | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.OCyUumkh.html | |||||
信州大学研究者総覧へのリンク | ||||||
氏名 | Ogawa, Shinichiro | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.PmnhOayC.html | |||||
信州大学研究者総覧へのリンク | ||||||
氏名 | Shindo, Takayuki | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.OCLpOayV.html | |||||
出版者 | ||||||
出版者 | ELSEVIER SCIENCE INC | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | PEPTIDES. 32(9):1855-1865 (2011) | |||||
書誌情報 |
PEPTIDES 巻 32, 号 9, p. 1855-1865, 発行日 2011-09 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Embryonic stem cells (ESCs) are a useful source for various cell lineages. So far, however, progress toward reconstitution of mature liver morphology and function has been limited. We have shown that knockout mice deficient in adrenomedullin (AM), a multifunctional endogenous peptide, or its receptor-activity modifying protein (RAMP2) die in utero due to poor vascular development and hemorrhage within the liver. In this study, using embryoid bodies (EBs)-culture system, we successfully induced liver sinusoidal endothelial-like cells by modulation of AM-RAMP2. In an EB differentiation system, we found that co-administration of AM and SB431542, an inhibitor of transforming growth factor beta (TGF beta) receptor type 1, markedly enhanced differentiation of lymphatic vessel endothelial hyaluronan receptor-1 (LYVE-1)/stabilin-2-positive endothelial cells. These cells showed robust endocytosis of acetylated low-density lipoprotein (Ac-LDL) and upregulated expression of liver sinusoidal endothelial cells (LSECs)-specific markers, including factor 8 (F8), Fc-gamma receptor 2b (Fcgr2b), and mannose receptor C type 1 (Mrc1), and also possessed fenestrae-like structure, a key morphological feature of LSECs. In RAMP2-null liver, by contrast, LYVE-1 was downregulated in LSECs, and the sinusoidal structure was disrupted. Our findings highlight the importance of AM-RAMP2 signaling for development of LSECs. (C) 2011 Elsevier Inc. All rights reserved. | |||||
資源タイプ(コンテンツの種類) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article | |||||
ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0196-9781 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10617807 | |||||
PubMed | ||||||
識別子タイプ | PMID | |||||
関連識別子 | https://pubmed.ncbi.nlm.nih.gov/21782867 | |||||
関連名称 | 21782867 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1016/j.peptides.2011.07.005 | |||||
関連名称 | 10.1016/j.peptides.2011.07.005 | |||||
権利 | ||||||
権利情報 | © 2011. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||
出版タイプ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
WoS | ||||||
表示名 | Web of Science | |||||
URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000295767400011 |