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Polymorphism in the KCNA3 gene is associated with susceptibility to autoimmune pancreatitis in the Japanese population
http://hdl.handle.net/10091/00020099
http://hdl.handle.net/10091/00020099a445947e-1ac1-4e9d-b72d-601217564b5e
名前 / ファイル | ライセンス | アクション |
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Polymorphism_in_the_KCNA3_Gene_Is_Associated_with_Susceptibility_to_Autoimmune_Pancreatitis.pdf (1.5 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-12-25 | |||||
タイトル | ||||||
タイトル | Polymorphism in the KCNA3 gene is associated with susceptibility to autoimmune pancreatitis in the Japanese population | |||||
言語 | en | |||||
言語 | ||||||
言語 | eng | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.3233/DMA-2011-0820 | |||||
関連名称 | 10.3233/DMA-2011-0820 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | AIP | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | autoimmune pancreatitis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | SNPs | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | KCNA3 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | disease susceptibility | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Ota, Masao
× Ota, Masao× Ito, Tetsuya× Umemura, Takeji× Katsuyama, Yoshihiko× Yoshizawa, Kaname× Hamano, Hideaki× Kawa, Shigeyuki |
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信州大学研究者総覧へのリンク | ||||||
表示名 | Ota, Masao | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.ZefVOFkh.html | |||||
信州大学研究者総覧へのリンク | ||||||
表示名 | Umemura, Takeji | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.ymSpgpkh.html | |||||
信州大学研究者総覧へのリンク | ||||||
表示名 | Kawa, Shigeyuki | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.jakeOVkh.html | |||||
出版者 | ||||||
出版者 | IOS PRESS | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | DISEASE MARKERS. 31(4):223-229 (2011) | |||||
書誌情報 |
DISEASE MARKERS 巻 31, 号 4, p. 223-229, 発行日 2011 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Autoimmune pancreatitis (AIP), characterized by irregular narrowing of the main pancreatic duct, swelling of the pancreas, and histological evidence of lymphoplasmacytic inflammation by high serum immunoglobulin G4, is distinct from ordinary pancreatitis. However, genetic factors involved in the etiology and pathophysiology of AIP remain unclear. Sixty-four patients with autoimmune pancreatitis (53 men, 11 women; mean age, 62.4 years) and 104 healthy Japanese controls were enrolled in this study. We performed an association analysis using 400 microsatellite markers with an average spacing of 10.8 cM in the genome. We also evaluated the association of AIP with seven single nucleotide polymorphisms (SNPs) within the 20-kb region around the potassium voltage-gated channel, shaker-related subfamily, member 3 gene (KCNA3). We identified six statistically significant markers (D1S2726, D5S410, D6S460, D10S548, D15S128, and D20S186; P < 0.05) related to susceptibility. The surrounding region showing the strong association (P = 7.4 x 10(-7), Pc = 0.0015) contained the KCNA3 gene. Further analysis by SNP genotyping in KCNA3 gene revealed that four SNPs (rs2840381, rs1058184, rs2640480, rs1319782) were significantly associated with the AIP susceptibility (P < 0.007). KCNA3 is known to be involved in immunomodulation of autoreactive effector and memory T cell-mediated autoimmune diseases. Our findings provide the first evidence that KCNA3 is associated with AIP and suggest that KCNA3 may influence the risk for AIP. | |||||
資源タイプ(コンテンツの種類) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article | |||||
ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0278-0240 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10619879 | |||||
PubMed | ||||||
識別子タイプ | PMID | |||||
関連識別子 | https://pubmed.ncbi.nlm.nih.gov/22045429 | |||||
関連名称 | 22045429 | |||||
権利 | ||||||
権利情報 | © 2011 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | |||||
出版タイプ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
WoS | ||||||
表示名 | Web of Science | |||||
URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000296751900006 |