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Thymidine-dependent small-colony variants (TD-SCVs) are difficult to detect or test for antimicrobial susceptibility. We investigated the characteristics of clonal TD-SCVs of Escherichia coli, both with and without bla(CTX-M-3), isolated from a patient. Methodology. Mutation in the thyA gene was analysed by sequencing, and morphological abnormalities in the colonies and cells of the isolates were examined. Additionally, conjugational transfer experiments were performed to prove the horizontal transferability of plasmids harbouring resistance genes. Results. The TD-SCVs contained a single nucleotide substitution in the thyA gene, c.62G\u003eA, corresponding to p.Arg21His. Morphologically, their colonies were more translucent and flattened than those of the wild-type strain. In addition, cells of the TD-SCVs were swollen and elongated, sometimes with abnormal and incomplete divisions; a large amount of cell debris was also observed. 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  1. 050 医学部, 大学院医学系研究科
  2. 0507 学位論文
  3. 博士(保健学)

Characterization of clinically isolated thymidine-dependent small-colony variants of Escherichia coli producing extended-spectrum β-lactamase(ESBL)(臨床検体より分離された基質拡張型β-ラクタマーゼ産生性Escherichia coliのチミジン要求性small-colony variantsの特徴)

http://hdl.handle.net/10091/00020701
6f660939-0e3e-471d-929e-3fdc204234fa
名前 / ファイル ライセンス アクション
15MK005C_yoshi.pdf 内容の要旨 (144.3 kB)
15MK005C_shinsa.pdf 審査結果の要旨 (160.6 kB)
15MK005C_ronbun.pdf 博士論文の全文 (1.3 MB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2018-06-27
タイトル
言語 en
タイトル Characterization of clinically isolated thymidine-dependent small-colony variants of Escherichia coli producing extended-spectrum β-lactamase(ESBL)(臨床検体より分離された基質拡張型β-ラクタマーゼ産生性Escherichia coliのチミジン要求性small-colony variantsの特徴)
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_db06
タイプ doctoral thesis
著者 根岸, 達哉

× 根岸, 達哉

WEKO 105893

根岸, 達哉

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出版者
出版者 信州大学
引用
内容記述タイプ Other
内容記述 根岸 達哉. Characterization of clinically isolated thymidine-dependent small-colony variants of Escherichia coli producing extended-spectrum β-lactamase(ESBL)(臨床検体より分離された基質拡張型β-ラクタマーゼ産生性Escherichia coliのチミジン要求性small-colony variantsの特徴). 信州大学, 2018, 博士論文.
書誌情報
発行日 2018-03-20
学位授与番号
学位授与番号 13601甲第22号
学位授与年月日
学位授与年月日 2018-03-20
学位名
学位名 博士(保健学)
学位授与機関
学位授与機関名
学位授与機関名 信州大学(Shinshu university)
学位の区分
Doctoral
学位の分野
保健学
学位の報告番号
甲第22号
内容記述
内容記述タイプ Other
内容記述 雑誌に発表。JOURNAL OF MEDICAL MICROBIOLOGY. 67(1):33-39 (2018); doi:10.1099/jmm.0.000634.
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Thesis
PubMed
関連識別子
識別子タイプ PMID
関連識別子 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search&DB=pubmed&term=29143727
関連名称
関連名称 29143727
DOI
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1099/jmm.0.000634
関連名称
関連名称 10.1099/jmm.0.000634
権利
権利情報 © 2018 The Authors. Published by the Microbiology Society.
出版タイプ
出版タイプ NA
出版タイプResource http://purl.org/coar/version/c_be7fb7dd8ff6fe43
WoS
Web of Science
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000425273400004
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