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Characterization of clinically isolated thymidine-dependent small-colony variants of Escherichia coli producing extended-spectrum \u03b2-lactamase(ESBL)\uff08\u81e8\u5e8a\u691c\u4f53\u3088\u308a\u5206\u96e2\u3055\u308c\u305f\u57fa\u8cea\u62e1\u5f35\u578b\u03b2-\u30e9\u30af\u30bf\u30de\u30fc\u30bc\u7523\u751f\u6027Escherichia coli\u306e\u30c1\u30df\u30b8\u30f3\u8981\u6c42\u6027small-colony variants\u306e\u7279\u5fb4\uff09. \u4fe1\u5dde\u5927\u5b66, 2018, \u535a\u58eb\u8ad6\u6587.", "subitem_description_type": "Other"}]}, "item_14_dissertation_number_7": {"attribute_name": "\u5b66\u4f4d\u6388\u4e0e\u756a\u53f7", "attribute_value_mlt": [{"subitem_dissertationnumber": "13601\u7532\u7b2c22\u53f7"}]}, "item_14_link_74": {"attribute_name": "WoS", "attribute_value_mlt": [{"subitem_link_text": "Web of Science", "subitem_link_url": "http://gateway.isiknowledge.com/gateway/Gateway.cgi?\u0026GWVersion=2\u0026SrcAuth=ShinshuUniv\u0026SrcApp=ShinshuUniv\u0026DestLinkType=FullRecord\u0026DestApp=WOS\u0026KeyUT=000425273400004"}]}, "item_14_publisher_4": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "\u4fe1\u5dde\u5927\u5b66"}]}, "item_14_relation_54": {"attribute_name": "PubMed", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "29143727"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search\u0026DB=pubmed\u0026term=29143727", "subitem_relation_type_select": "PMID"}}]}, "item_14_relation_55": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "10.1099/jmm.0.000634"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1099/jmm.0.000634", "subitem_relation_type_select": "DOI"}}]}, "item_14_rights_69": {"attribute_name": "\u6a29\u5229", "attribute_value_mlt": [{"subitem_rights": "\u00a9 2018 The Authors. 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Thymidine-dependent small-colony variants (TD-SCVs) are difficult to detect or test for antimicrobial susceptibility. We investigated the characteristics of clonal TD-SCVs of Escherichia coli, both with and without bla(CTX-M-3), isolated from a patient. Methodology. Mutation in the thyA gene was analysed by sequencing, and morphological abnormalities in the colonies and cells of the isolates were examined. Additionally, conjugational transfer experiments were performed to prove the horizontal transferability of plasmids harbouring resistance genes. Results. The TD-SCVs contained a single nucleotide substitution in the thyA gene, c.62G\u003eA, corresponding to p.Arg21His. Morphologically, their colonies were more translucent and flattened than those of the wild-type strain. In addition, cells of the TD-SCVs were swollen and elongated, sometimes with abnormal and incomplete divisions; a large amount of cell debris was also observed. Changing c.62G\u003eA back to the wild-type sequence reversed these abnormalities. Conjugational transfer experiments showed that the TD-SCV of E. coli with bla(CTX-M-3) failed to transfer bla(CTX-M-3) to E. coli CSH2. However, the TD-SCV of E. coli without bla(CTX-M-3) experimentally received the plasmid encoding blaSHV-18 from Klebsiella pneumoniae ATCC 700603 and transferred it to E. coli CSH2. Conclusion. Mutation in the thyA gene causes morphological abnormalities in the colonies and cells of E. coli, as well as inducing thymidine auxotrophy. In addition, TD-SCVs horizontally transmit plasmids encoding resistance genes. 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Characterization of clinically isolated thymidine-dependent small-colony variants of Escherichia coli producing extended-spectrum β-lactamase(ESBL)(臨床検体より分離された基質拡張型β-ラクタマーゼ産生性Escherichia coliのチミジン要求性small-colony variantsの特徴)
http://hdl.handle.net/10091/00020701
6f660939-0e3e-471d-929e-3fdc204234fa
名前 / ファイル | ライセンス | アクション | |
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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公開日 | 2018-06-27 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Characterization of clinically isolated thymidine-dependent small-colony variants of Escherichia coli producing extended-spectrum β-lactamase(ESBL)(臨床検体より分離された基質拡張型β-ラクタマーゼ産生性Escherichia coliのチミジン要求性small-colony variantsの特徴) | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_db06 | |||||
タイプ | doctoral thesis | |||||
著者 |
根岸, 達哉
× 根岸, 達哉 |
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出版者 | ||||||
出版者 | 信州大学 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 根岸 達哉. Characterization of clinically isolated thymidine-dependent small-colony variants of Escherichia coli producing extended-spectrum β-lactamase(ESBL)(臨床検体より分離された基質拡張型β-ラクタマーゼ産生性Escherichia coliのチミジン要求性small-colony variantsの特徴). 信州大学, 2018, 博士論文. | |||||
書誌情報 |
発行日 2018-03-20 |
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学位授与番号 | ||||||
学位授与番号 | 13601甲第22号 | |||||
学位授与年月日 | ||||||
学位授与年月日 | 2018-03-20 | |||||
学位名 | ||||||
学位名 | 博士(保健学) | |||||
学位授与機関 | ||||||
学位授与機関名 | ||||||
学位授与機関名 | 信州大学(Shinshu university) | |||||
学位の区分 | ||||||
Doctoral | ||||||
学位の分野 | ||||||
保健学 | ||||||
学位の報告番号 | ||||||
甲第22号 | ||||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 雑誌に発表。JOURNAL OF MEDICAL MICROBIOLOGY. 67(1):33-39 (2018); doi:10.1099/jmm.0.000634. | |||||
資源タイプ(コンテンツの種類) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Thesis | |||||
PubMed | ||||||
関連識別子 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search&DB=pubmed&term=29143727 | |||||
関連名称 | ||||||
関連名称 | 29143727 | |||||
DOI | ||||||
関連識別子 | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1099/jmm.0.000634 | |||||
関連名称 | ||||||
関連名称 | 10.1099/jmm.0.000634 | |||||
権利 | ||||||
権利情報 | © 2018 The Authors. Published by the Microbiology Society. | |||||
出版タイプ | ||||||
出版タイプ | NA | |||||
出版タイプResource | http://purl.org/coar/version/c_be7fb7dd8ff6fe43 | |||||
WoS | ||||||
Web of Science | ||||||
URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000425273400004 |