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This study was conducted in order to evaluate the renal protective effect of adding tolvaptan (TLV), compared to increasing the furosemide (FRM) dose, for the treatment of acute decompensated heart failure (ADHF) in a real-world elderly patient population. Methods: This randomized controlled trial enrolled 52 consecutive hospitalized patients (age 83.4 +/- 9.6 years) with ADHF. The patients were assigned alternately to either the TLV group (TLV plus conventional treatment, n = 26) or the FRM group (increasing the dose of FRM, n = 26). TLV was administered within 24 h from admission. Results: The incidence of worsening renal function (WRF) within 7 days from admission was significantly lower in the TLV group (26.9% vs. 57.7%, p = 0.025). Furthermore, the rates of occurrence of persistent and late-onset (\u003e= 5 days from admission) WRF were significantly lower in the TLV group. Persistent and late-onset WRF were significantly associated with a higher incidence of cardiac death or readmission for worsening heart failure in the 90 days following discharge, compared to transient and early-onset WRF, respectively. Conclusions: Early administration of TLV, compared to increased FRM dosage, reduces the incidence of WRF in real-world elderly ADHF patients. In addition, it reduces the occurrence of \u0027worse\u0027 WRF-persistent and late-onset WRF-which are associated with increased rates of cardiac death or readmission for worsening heart failure in the 90 days after discharge. (C) 2015 Japanese College of Cardiology. Published by Elsevier Ltd. 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  1. 050 医学部, 大学院医学系研究科
  2. 0507 学位論文
  3. 博士(医学)

Early administration of tolvaptan preserves renal function in elderly patients with acute decompensated heart failure(高齢急性非代償性心不全患者へのトルバプタン早期投与は腎機能を保護する)

http://hdl.handle.net/10091/00020702
90ec2474-ee86-4570-addc-28187e864254
名前 / ファイル ライセンス アクション
13MH015A_yoshi.pdf 内容の要旨 (125.9 kB)
13MH015A_shinsa.pdf 審査結果の要旨 (119.5 kB)
13MH015A_ronbun.pdf 博士論文の全文 (1.1 MB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2018-06-28
タイトル
言語 en
タイトル Early administration of tolvaptan preserves renal function in elderly patients with acute decompensated heart failure(高齢急性非代償性心不全患者へのトルバプタン早期投与は腎機能を保護する)
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_db06
タイプ doctoral thesis
著者 木村, 和広

× 木村, 和広

WEKO 105894

木村, 和広

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出版者
出版者 信州大学
引用
内容記述タイプ Other
内容記述 木村 和広. Early administration of tolvaptan preserves renal function in elderly patients with acute decompensated heart failure(高齢急性非代償性心不全患者へのトルバプタン早期投与は腎機能を保護する). 信州大学, 2017, 博士論文.
書誌情報
発行日 2017-03-31
学位授与番号
学位授与番号 13601甲第1096号
学位授与年月日
学位授与年月日 2017-03-31
学位名
学位名 博士(医学)
学位授与機関
学位授与機関名
学位授与機関名 信州大学(Shinshu university)
学位の区分
Doctoral
学位の分野
医学
学位の報告番号
甲第1096号
内容記述
内容記述タイプ Other
内容記述 雑誌に発表。JOURNAL OF CARDIOLOGY. 67(5-6):399-405 (2016); doi:10.1016/j.jjcc.2015.09.020.
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Thesis
PubMed
関連識別子
識別子タイプ PMID
関連識別子 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search&DB=pubmed&term=26692119
関連名称
関連名称 26692119
DOI
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1016/j.jjcc.2015.09.020
関連名称
関連名称 10.1016/j.jjcc.2015.09.020
権利
権利情報 © 2015 Japanese College of Cardiology. Published by Elsevier Ireland Ltd. All rights reserved.
出版タイプ
出版タイプ NA
出版タイプResource http://purl.org/coar/version/c_be7fb7dd8ff6fe43
WoS
Web of Science
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000377819600002
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