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However, the significance of high ABI remains poorly understood. This study aimed to assess the characteristics and outcomes of patients with high ABI. Methods The IMPACT-ABI study was a retrospective cohort study that enrolled and examined ABI in 3,131 patients hospitalized for cardiovascular disease between January 2005 and December 2012. From this cohort, 2,419 patients were identified and stratified into two groups: high ABI (\u003e 1.4; 2.6%) and normal ABI (1.0-1.4; 97.3%). The primary endpoint was the cumulative incidence of major adverse cardiovascular events (MACE), including cardiovascular-associated death, myocardial infarction, and stroke. Results Compared with the normal ABI group, patients in the high ABI group showed significantly lower body mass index (BMI) and hemoglobin level, but had higher incidence of chronic kidney disease and hemodialysis. Multivariate logistic regression analysis revealed that hemodialysis was the strongest predictor of high ABI (odds ratio, 6.18; 95% confidence interval (CI), 3.05-12.52; P \u003c 0.001). During the follow-up (median, 4.7 years), 172 cases of MACE occurred. Cumulative MACE incidence in patients with high ABI was significantly increased compared to that in those with normal ABI (32.5% vs. 14.5%; P = 0.005). In traditional cardiovascular risk factors-adjusted multivariate Cox proportional hazard analysis, high ABI was an independent predictor of MACE (hazard ratio, 2.07; 95% CI, 1.02-4.20; P = 0.044). Conclusion Lower BMI, chronic kidney disease, and hemodialysis are more frequent in patients with high ABI. Hemodialysis is the strongest predictor of high ABI. 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  1. 050 医学部, 大学院医学系研究科
  2. 0507 学位論文
  3. 博士(医学)

Clinical Characteristics and Outcomes of Patients with High Ankle-Brachial Index from the IMPACT-ABIStudy(ABI高値を呈する患者群の臨床的特徴及び予後検討)

http://hdl.handle.net/10091/00020705
ad458637-0beb-43d0-82c0-90d199472612
名前 / ファイル ライセンス アクション
14MH032D_yoshi.pdf 内容の要旨 (150.3 kB)
14MH032D_shinsa.pdf 審査結果の要旨 (134.9 kB)
14MH032D_ronbun.pdf 博士論文の全文 (486.3 kB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2018-06-28
タイトル
言語 en
タイトル Clinical Characteristics and Outcomes of Patients with High Ankle-Brachial Index from the IMPACT-ABIStudy(ABI高値を呈する患者群の臨床的特徴及び予後検討)
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_db06
タイプ doctoral thesis
著者 西村, 仁志

× 西村, 仁志

WEKO 105897

西村, 仁志

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出版者
出版者 信州大学
引用
内容記述タイプ Other
内容記述 西村 仁志. Clinical Characteristics and Outcomes of Patients with High Ankle-Brachial Index from the IMPACT-ABIStudy(ABI高値を呈する患者群の臨床的特徴及び予後検討). 信州大学, 2018, 博士論文.
書誌情報
発行日 2018-03-31
学位授与番号
学位授与番号 13601甲第1099号
学位授与年月日
学位授与年月日 2018-03-31
学位名
学位名 博士(医学)
学位授与機関
学位授与機関名
学位授与機関名 信州大学(Shinshu university)
学位の区分
Doctoral
学位の分野
医学
学位の報告番号
甲第1099号
内容記述
内容記述タイプ Other
内容記述 雑誌に発表。PLOS ONE. 11(11):e0167150 (2016); doi:10.1371/journal.pone.0167150.
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Thesis
PubMed
関連識別子
識別子タイプ PMID
関連識別子 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search&DB=pubmed&term=27880852
関連名称
関連名称 27880852
DOI
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1371/journal.pone.0167150
関連名称
関連名称 10.1371/journal.pone.0167150
権利
権利情報 © 2016 Nishimura et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. / Nishimura H, Miura T, Minamisawa M, Ueki Y, Abe N, Hashizume N, et al. (2016) Clinical Characteristics and Outcomes of Patients with High Ankle-Brachial Index from the IMPACT-ABI Study. PLoS ONE 11(11): e0167150. doi:10.1371/journal. pone.0167150
出版タイプ
出版タイプ NA
出版タイプResource http://purl.org/coar/version/c_be7fb7dd8ff6fe43
WoS
Web of Science
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000388889500073
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