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MethodsWe retrospectively studied 133 patients who had undergone dynamic CT before hepatectomy. Fibrosis was histologically established in all. First we calculated splenic perfusion parameters K-1 (inflow rate constant), 1/k(2) (mean transit time; MTT), and K-1/k(2) (distribution volume; V-d), using compartment model analysis. Then we compared the stage of fibrosis with splenic perfusion and spleen size (long axis, R), using the Kruskal-Wallis test and multiple comparisons. After that, we assessed the diagnostic accuracy of the combination of splenic perfusion, spleen size, age, gender, and the presence or absence of hepatitis B and hepatitis C viral infection in detecting liver fibrosis, using stepwise regression and receiver operating characteristic analysis. ResultsSignificant differences (P\u003c0.05) in MTT were observed in comparisons between fibrosis stages F0 and F4, between F1 and F4, and between F2 and F4. Significant differences (P\u003c0.05) in R were observed in comparisons between F0 and F4, and between F1 and F4. Considering the presence or absence of hepatitis B and C viral infection along with MTT and R, the areas under the receiver operating characteristic curves were 0.89 for F1, 0.83 for F2, 0.82 for F3, and 0.82 for F4. 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  1. 050 医学部, 大学院医学系研究科
  2. 0507 学位論文
  3. 博士(医学)

Evaluation of splenic perfusion and spleen size using dynamic computed tomography: usefulness in assessing degree of liver fibrosis(ダイナミックCTによる脾臓径および脾血流動態の評価:肝線維化評価における有用性)

http://hdl.handle.net/10091/00020706
ce72fd5c-1d6e-4c3c-91d8-74b85d1fe7c1
名前 / ファイル ライセンス アクション
14MH025A_yoshi.pdf 内容の要旨 (119.1 kB)
14MH025A_shinsa.pdf 審査結果の要旨 (108.0 kB)
14MH025A_ronbun.pdf 博士論文の全文 (414.1 kB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2018-06-28
タイトル
言語 en
タイトル Evaluation of splenic perfusion and spleen size using dynamic computed tomography: usefulness in assessing degree of liver fibrosis(ダイナミックCTによる脾臓径および脾血流動態の評価:肝線維化評価における有用性)
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_db06
タイプ doctoral thesis
著者 鈴木, 健史

× 鈴木, 健史

WEKO 105898

鈴木, 健史

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出版者
出版者 信州大学
引用
内容記述タイプ Other
内容記述 鈴木 健史. Evaluation of splenic perfusion and spleen size using dynamic computed tomography: usefulness in assessing degree of liver fibrosis(ダイナミックCTによる脾臓径および脾血流動態の評価:肝線維化評価における有用性). 信州大学, 2018, 博士論文.
書誌情報
発行日 2018-03-31
学位授与番号
学位授与番号 13601甲第1100号
学位授与年月日
学位授与年月日 2018-03-31
学位名
学位名 博士(医学)
学位授与機関
学位授与機関名
学位授与機関名 信州大学(Shinshu university)
学位の区分
Doctoral
学位の分野
医学
学位の報告番号
甲第1100号
内容記述
内容記述タイプ Other
内容記述 雑誌に発表。HEPATOLOGY RESEARCH. 48(1):87-93 (2018); doi:10.1111/hepr.12900.
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Thesis
PubMed
関連識別子
識別子タイプ PMID
関連識別子 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search&DB=pubmed&term=28370772
関連名称
関連名称 28370772
DOI
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1111/hepr.12900
関連名称
関連名称 10.1111/hepr.12900
権利
権利情報 © 2017 The Japan Society of Hepatology / This is the peer reviewed version of the following article: Suzuki, T., Yamada, A., Komatsu, D., Kurozumi, M., Fujinaga, Y., Ueda, K., Miyagawa, S., and Kadoya, M. (2018) Evaluation of splenic perfusion and spleen size using dynamic computed tomography: Usefulness in assessing degree of liver fibrosis. Hepatol Res, 48: 87–93. doi: 10.1111/hepr.12900, which has been published in final form at https://doi.org/10.1111/hepr.12900 . This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
出版タイプ
出版タイプ NA
出版タイプResource http://purl.org/coar/version/c_be7fb7dd8ff6fe43
WoS
Web of Science
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000419347800011
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