{"_buckets": {"deposit": "b43bdd35-26b8-4a4b-b8f3-784aa253d2bd"}, "_deposit": {"id": "19945", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "19945"}, "status": "published"}, "_oai": {"id": "oai:soar-ir.repo.nii.ac.jp:00019945", "sets": []}, "author_link": ["105898"], "item_14_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2018-03-31", "bibliographicIssueDateType": "Issued"}}]}, "item_14_date_granted_8": {"attribute_name": "学位授与年月日", "attribute_value_mlt": [{"subitem_dategranted": "2018-03-31"}]}, "item_14_degree_grantor_10": {"attribute_name": "学位授与機関", "attribute_value_mlt": [{"subitem_degreegrantor": [{"subitem_degreegrantor_name": "信州大学(Shinshu university)"}], "subitem_degreegrantor_identifier": [{"subitem_degreegrantor_identifier_name": "13601", "subitem_degreegrantor_identifier_scheme": "kakenhi"}]}]}, "item_14_degree_name_9": {"attribute_name": "学位名", "attribute_value_mlt": [{"subitem_degreename": "博士（医学）"}]}, "item_14_description_26": {"attribute_name": "内容記述", "attribute_value_mlt": [{"subitem_description": "雑誌に発表。HEPATOLOGY RESEARCH. 48(1):87-93 (2018); doi:10.1111/hepr.12900.", "subitem_description_type": "Other"}]}, "item_14_description_37": {"attribute_name": "資源タイプ（コンテンツの種類）", "attribute_value_mlt": [{"subitem_description": "Thesis", "subitem_description_type": "Other"}]}, "item_14_description_5": {"attribute_name": "引用", "attribute_value_mlt": [{"subitem_description": "鈴木　健史. Evaluation of splenic perfusion and spleen size using dynamic computed tomography: usefulness in assessing degree of liver fibrosis（ダイナミックCTによる脾臓径および脾血流動態の評価：肝線維化評価における有用性）. 信州大学, 2018, 博士論文.", "subitem_description_type": "Other"}]}, "item_14_dissertation_number_7": {"attribute_name": "学位授与番号", "attribute_value_mlt": [{"subitem_dissertationnumber": "13601甲第1100号"}]}, "item_14_link_74": {"attribute_name": "WoS", "attribute_value_mlt": [{"subitem_link_text": "Web of Science", "subitem_link_url": "http://gateway.isiknowledge.com/gateway/Gateway.cgi?\u0026GWVersion=2\u0026SrcAuth=ShinshuUniv\u0026SrcApp=ShinshuUniv\u0026DestLinkType=FullRecord\u0026DestApp=WOS\u0026KeyUT=000419347800011"}]}, "item_14_publisher_4": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "信州大学"}]}, "item_14_relation_54": {"attribute_name": "PubMed", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "28370772"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://pubmed.ncbi.nlm.nih.gov/28370772/", "subitem_relation_type_select": "PMID"}}]}, "item_14_relation_55": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "10.1111/hepr.12900"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1111/hepr.12900", "subitem_relation_type_select": "DOI"}}]}, "item_14_rights_69": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "© 2017 The Japan Society of Hepatology / This is the peer reviewed version of the following article: Suzuki, T., Yamada, A., Komatsu, D., Kurozumi, M., Fujinaga, Y., Ueda, K., Miyagawa, S., and Kadoya, M. (2018) Evaluation of splenic perfusion and spleen size using dynamic computed tomography: Usefulness in assessing degree of liver fibrosis. Hepatol Res, 48: 87–93. doi: 10.1111/hepr.12900, which has been published in final form at https://doi.org/10.1111/hepr.12900 . This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving."}]}, "item_14_select_71": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "ETD"}]}, "item_14_text_11": {"attribute_name": "学位の区分", "attribute_value_mlt": [{"subitem_text_value": "doctoral"}]}, "item_14_text_12": {"attribute_name": "学位の分野", "attribute_value_mlt": [{"subitem_text_value": "医学"}]}, "item_14_text_13": {"attribute_name": "学位の報告番号", "attribute_value_mlt": [{"subitem_text_value": "甲第1100号"}]}, "item_14_text_76": {"attribute_name": "wosonly authkey", "attribute_value_mlt": [{"subitem_text_value": "liver fibrosis; multidetector computed tomography; perfusion; portal hypertension; spleen"}]}, "item_14_text_77": {"attribute_name": "wosonly keywords", "attribute_value_mlt": [{"subitem_text_value": "PORTAL-HYPERTENSION; HEPATOCELLULAR-CARCINOMA; CONTRAST MATERIAL; VIRUS-INFECTION; NITRIC-OXIDE; HEPATITIS-B; BLOOD-FLOW; CT; CIRRHOSIS; PATHOPHYSIOLOGY"}]}, "item_14_textarea_75": {"attribute_name": "wosonly abstract", "attribute_value_mlt": [{"subitem_textarea_value": "AimTo enhance the usefulness of splenic perfusion evaluated by means of dynamic computed tomography (CT) and spleen size in assessing the degree of liver fibrosis. MethodsWe retrospectively studied 133 patients who had undergone dynamic CT before hepatectomy. Fibrosis was histologically established in all. First we calculated splenic perfusion parameters K-1 (inflow rate constant), 1/k(2) (mean transit time; MTT), and K-1/k(2) (distribution volume; V-d), using compartment model analysis. Then we compared the stage of fibrosis with splenic perfusion and spleen size (long axis, R), using the Kruskal-Wallis test and multiple comparisons. After that, we assessed the diagnostic accuracy of the combination of splenic perfusion, spleen size, age, gender, and the presence or absence of hepatitis B and hepatitis C viral infection in detecting liver fibrosis, using stepwise regression and receiver operating characteristic analysis. ResultsSignificant differences (P\u003c0.05) in MTT were observed in comparisons between fibrosis stages F0 and F4, between F1 and F4, and between F2 and F4. Significant differences (P\u003c0.05) in R were observed in comparisons between F0 and F4, and between F1 and F4. Considering the presence or absence of hepatitis B and C viral infection along with MTT and R, the areas under the receiver operating characteristic curves were 0.89 for F1, 0.83 for F2, 0.82 for F3, and 0.82 for F4. ConclusionSplenic MTT and spleen size are helpful in assessing liver fibrosis."}]}, "item_1627890986942": {"attribute_name": "出版タイプ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_be7fb7dd8ff6fe43", "subitem_version_type": "NA"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "open access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_abf2"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "鈴木, 健史", "creatorNameLang": "ja"}], "nameIdentifiers": [{"nameIdentifier": "105898", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-06-28"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "14MH025A_yoshi.pdf", "filesize": [{"value": "119.1 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 119100.0, "url": {"label": "内容の要旨", "url": "https://soar-ir.repo.nii.ac.jp/record/19945/files/14MH025A_yoshi.pdf"}, "version_id": "5f5b985d-329f-419f-bffd-885986c665ea"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-06-28"}], "displaytype": "detail", "download_preview_message": "", "file_order": 1, "filename": "14MH025A_shinsa.pdf", "filesize": [{"value": "108.0 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 108000.0, "url": {"label": "審査結果の要旨", "url": "https://soar-ir.repo.nii.ac.jp/record/19945/files/14MH025A_shinsa.pdf"}, "version_id": "7bcc7d09-8673-4238-86a0-7896b9f51ec5"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-06-28"}], "displaytype": "detail", "download_preview_message": "", "file_order": 2, "filename": "14MH025A_ronbun.pdf", "filesize": [{"value": "414.1 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensefree": "© 2017 The Japan Society of Hepatology / This is the peer reviewed version of the following article: Suzuki, T., Yamada, A., Komatsu, D., Kurozumi, M., Fujinaga, Y., Ueda, K., Miyagawa, S., and Kadoya, M. (2018) Evaluation of splenic perfusion and spleen size using dynamic computed tomography: Usefulness in assessing degree of liver fibrosis. Hepatol Res, 48: 87–93. doi: 10.1111/hepr.12900, which has been published in final form at https://doi.org/10.1111/hepr.12900 . This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.", "licensetype": "license_note", "mimetype": "application/pdf", "size": 414100.0, "url": {"label": "博士論文の全文", "objectType": "fulltext", "url": "https://soar-ir.repo.nii.ac.jp/record/19945/files/14MH025A_ronbun.pdf"}, "version_id": "3c6aebea-696d-456a-afba-f06a333f13ed"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "doctoral thesis", "resourceuri": "http://purl.org/coar/resource_type/c_db06"}]}, "item_title": "Evaluation of splenic perfusion and spleen size using dynamic computed tomography: usefulness in assessing degree of liver fibrosis（ダイナミックCTによる脾臓径および脾血流動態の評価：肝線維化評価における有用性）", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Evaluation of splenic perfusion and spleen size using dynamic computed tomography: usefulness in assessing degree of liver fibrosis（ダイナミックCTによる脾臓径および脾血流動態の評価：肝線維化評価における有用性）", "subitem_title_language": "en"}]}, "item_type_id": "14", "owner": "1", "path": ["849"], "permalink_uri": "http://hdl.handle.net/10091/00020706", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2018-06-28"}, "publish_date": "2018-06-28", "publish_status": "0", "recid": "19945", "relation": {}, "relation_version_is_last": true, "title": ["Evaluation of splenic perfusion and spleen size using dynamic computed tomography: usefulness in assessing degree of liver fibrosis（ダイナミックCTによる脾臓径および脾血流動態の評価：肝線維化評価における有用性）"], "weko_shared_id": -1}