ログイン
言語:

WEKO3

  • トップ
  • コミュニティ
  • ランキング
AND
To
lat lon distance
To

Field does not validate



インデックスリンク

インデックスツリー

メールアドレスを入力してください。

WEKO

One fine body…

WEKO

One fine body…

アイテム

{"_buckets": {"deposit": "a0a46dfb-fd26-4342-b3c5-f43b51c195cf"}, "_deposit": {"id": "19948", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "19948"}, "status": "published"}, "_oai": {"id": "oai:soar-ir.repo.nii.ac.jp:00019948", "sets": []}, "author_link": ["105901"], "item_14_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2017-09-30", "bibliographicIssueDateType": "Issued"}}]}, "item_14_date_granted_8": {"attribute_name": "\u5b66\u4f4d\u6388\u4e0e\u5e74\u6708\u65e5", "attribute_value_mlt": [{"subitem_dategranted": "2017-09-30"}]}, "item_14_degree_grantor_10": {"attribute_name": "\u5b66\u4f4d\u6388\u4e0e\u6a5f\u95a2", "attribute_value_mlt": [{"subitem_degreegrantor": [{"subitem_degreegrantor_name": "\u4fe1\u5dde\u5927\u5b66(Shinshu university)"}]}]}, "item_14_degree_name_9": {"attribute_name": "\u5b66\u4f4d\u540d", "attribute_value_mlt": [{"subitem_degreename": "\u535a\u58eb\uff08\u533b\u5b66\uff09"}]}, "item_14_description_26": {"attribute_name": "\u5185\u5bb9\u8a18\u8ff0", "attribute_value_mlt": [{"subitem_description": "\u96d1\u8a8c\u306b\u767a\u8868\u3002TRANSLATIONAL ONCOLOGY. 10(4):621-631 (2017); doi:10.1016/j.tranon.2017.05.005.", "subitem_description_type": "Other"}]}, "item_14_description_37": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7\uff08\u30b3\u30f3\u30c6\u30f3\u30c4\u306e\u7a2e\u985e\uff09", "attribute_value_mlt": [{"subitem_description": "Thesis", "subitem_description_type": "Other"}]}, "item_14_description_5": {"attribute_name": "\u5f15\u7528", "attribute_value_mlt": [{"subitem_description": "MVUNTA DAVID HAMISI. SIRT1 regulates the chemoresistance, and invasiveness of ovarian carcinoma cells\uff08SIRT1\u306f\u5375\u5de3\u764c\u7d30\u80de\u306e\u6297\u304c\u3093\u5264\u8010\u6027\u304a\u3088\u3073\u6d78\u6f64\u80fd\u3092\u8abf\u7bc0\u3059\u308b\uff09. \u4fe1\u5dde\u5927\u5b66, 2017, \u535a\u58eb\u8ad6\u6587.", "subitem_description_type": "Other"}]}, "item_14_dissertation_number_7": {"attribute_name": "\u5b66\u4f4d\u6388\u4e0e\u756a\u53f7", "attribute_value_mlt": [{"subitem_dissertationnumber": "13601\u7532\u7b2c1103\u53f7"}]}, "item_14_link_74": {"attribute_name": "WoS", "attribute_value_mlt": [{"subitem_link_text": "Web of Science", "subitem_link_url": "http://gateway.isiknowledge.com/gateway/Gateway.cgi?\u0026GWVersion=2\u0026SrcAuth=ShinshuUniv\u0026SrcApp=ShinshuUniv\u0026DestLinkType=FullRecord\u0026DestApp=WOS\u0026KeyUT=000407707700018"}]}, "item_14_publisher_4": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "\u4fe1\u5dde\u5927\u5b66"}]}, "item_14_relation_54": {"attribute_name": "PubMed", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "28667895"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search\u0026DB=pubmed\u0026term=28667895", "subitem_relation_type_select": "PMID"}}]}, "item_14_relation_55": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "10.1016/j.tranon.2017.05.005"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1016/j.tranon.2017.05.005", "subitem_relation_type_select": "DOI"}}]}, "item_14_rights_69": {"attribute_name": "\u6a29\u5229", "attribute_value_mlt": [{"subitem_rights": "\u00a9 2017 The Authors. Published by Elsevier Inc. on behalf of Neoplasia Press, Inc."}]}, "item_14_select_71": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "ETD"}]}, "item_14_text_11": {"attribute_name": "\u5b66\u4f4d\u306e\u533a\u5206", "attribute_value_mlt": [{"subitem_text_value": "Doctoral"}]}, "item_14_text_12": {"attribute_name": "\u5b66\u4f4d\u306e\u5206\u91ce", "attribute_value_mlt": [{"subitem_text_value": "\u533b\u5b66"}]}, "item_14_text_13": {"attribute_name": "\u5b66\u4f4d\u306e\u5831\u544a\u756a\u53f7", "attribute_value_mlt": [{"subitem_text_value": "\u7532\u7b2c1103\u53f7"}]}, "item_14_text_77": {"attribute_name": "wosonly keywords", "attribute_value_mlt": [{"subitem_text_value": "CANCER STEM-CELLS; UP-REGULATION; CISPLATIN RESISTANCE; INITIATING CELLS; PROSTATE-CANCER; BREAST-CANCER; CD44 VARIANT; EXPRESSION; APOPTOSIS; PROMOTES"}]}, "item_14_textarea_75": {"attribute_name": "wosonly abstract", "attribute_value_mlt": [{"subitem_textarea_value": "BACKGROUND: SIRT1 is a longevity gene that forestalls aging and age-related diseases including cancer, and has recently attracted widespread attention due to its overexpression in some cancers. We previously identified the overexpression of SIRT1 in ovarian carcinoma (OvCa) as a poor prognostic factor. However, mechanistic insights into the function of SIRT1 in OvCa have yet to be elucidated. METHODS: Quantitative real-time reverse PCR (qRTPCR) and Western blotting were employed to examine the expression of SIRT1 in a panel of human OvCa cell lines. si-RNA or sh-RNA and cDNA technologies were utilized to knockdown or overexpress SIRT1, respectively. The effects of SIRT1 on proliferation and chemoresistance were examined using a WST-1 assay, and the underlying mechanisms were confirmed using an apoptotic assay, and the quantification of glutathione (GSH), and reactive oxygen species (ROS). The aggressiveness of SIRT1 was analyzed using in vitro invasion and migration assays. RESULTS: SIRT1 was more strongly expressed in OvCa cell lines than in the immortalized ovarian epithelium at the gene and protein levels. Stress up-regulated the expression of SIRT1 in dose-and time-dependent manners. SIRT1 significantly enhanced the proliferation (P \u003c.05), chemoresistance (P \u003c.05), and aggressiveness of OvCa cells by up-regulating multiple antioxidant pathways to inhibit oxidative stress. Further study into the overexpression of SIRT1 demonstrated the up-regulation of several stemness-associated genes and enrichment of CD44v9 via an asyet- unidentified pathway. CONCLUSIONS: Our results suggest that SIRT1 plays a role in the acquisition of aggressiveness and chemoresistance by OvCa, and has potential as a therapeutic target for OvCa."}]}, "item_1627890986942": {"attribute_name": "\u51fa\u7248\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_be7fb7dd8ff6fe43", "subitem_version_type": "NA"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "MVUNTA, DAVID HAMISI"}], "nameIdentifiers": [{"nameIdentifier": "105901", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-06-28"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "13MH081J_yoshi.pdf", "filesize": [{"value": "122.1 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 122100.0, "url": {"label": "\u5185\u5bb9\u306e\u8981\u65e8", "url": "https://soar-ir.repo.nii.ac.jp/record/19948/files/13MH081J_yoshi.pdf"}, "version_id": "33fb1d72-fd10-4934-bd46-21c3a7090791"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-06-28"}], "displaytype": "detail", "download_preview_message": "", "file_order": 1, "filename": "13MH081J_shinsa.pdf", "filesize": [{"value": "111.3 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 111300.0, "url": {"label": "\u5be9\u67fb\u7d50\u679c\u306e\u8981\u65e8", "url": "https://soar-ir.repo.nii.ac.jp/record/19948/files/13MH081J_shinsa.pdf"}, "version_id": "7b48b59c-dbf4-4848-bae4-882afaf05591"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-06-28"}], "displaytype": "detail", "download_preview_message": "", "file_order": 2, "filename": "13MH081J_ronbun.pdf", "filesize": [{"value": "1.5 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensefree": "\u00a9 2017 The Authors. Published by Elsevier Inc. on behalf of Neoplasia Press, Inc.", "licensetype": "license_note", "mimetype": "application/pdf", "size": 1500000.0, "url": {"label": "\u535a\u58eb\u8ad6\u6587\u306e\u5168\u6587", "url": "https://soar-ir.repo.nii.ac.jp/record/19948/files/13MH081J_ronbun.pdf"}, "version_id": "1930e2e4-2378-4f50-8895-97e2b0ccbea5"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "doctoral thesis", "resourceuri": "http://purl.org/coar/resource_type/c_db06"}]}, "item_title": "SIRT1 regulates the chemoresistance, and invasiveness of ovarian carcinoma cells\uff08SIRT1\u306f\u5375\u5de3\u764c\u7d30\u80de\u306e\u6297\u304c\u3093\u5264\u8010\u6027\u304a\u3088\u3073\u6d78\u6f64\u80fd\u3092\u8abf\u7bc0\u3059\u308b\uff09", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "SIRT1 regulates the chemoresistance, and invasiveness of ovarian carcinoma cells\uff08SIRT1\u306f\u5375\u5de3\u764c\u7d30\u80de\u306e\u6297\u304c\u3093\u5264\u8010\u6027\u304a\u3088\u3073\u6d78\u6f64\u80fd\u3092\u8abf\u7bc0\u3059\u308b\uff09", "subitem_title_language": "en"}]}, "item_type_id": "14", "owner": "1", "path": ["461/848/849"], "permalink_uri": "http://hdl.handle.net/10091/00020709", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2018-06-28"}, "publish_date": "2018-06-28", "publish_status": "0", "recid": "19948", "relation": {}, "relation_version_is_last": true, "title": ["SIRT1 regulates the chemoresistance, and invasiveness of ovarian carcinoma cells\uff08SIRT1\u306f\u5375\u5de3\u764c\u7d30\u80de\u306e\u6297\u304c\u3093\u5264\u8010\u6027\u304a\u3088\u3073\u6d78\u6f64\u80fd\u3092\u8abf\u7bc0\u3059\u308b\uff09"], "weko_shared_id": -1}
  1. 050 医学部, 大学院医学系研究科
  2. 0507 学位論文
  3. 博士(医学)

SIRT1 regulates the chemoresistance, and invasiveness of ovarian carcinoma cells(SIRT1は卵巣癌細胞の抗がん剤耐性および浸潤能を調節する)

http://hdl.handle.net/10091/00020709
69532176-dde3-42b6-87cb-3e37f5d6a8ba
名前 / ファイル ライセンス アクション
13MH081J_yoshi.pdf 内容の要旨 (122.1 kB)
13MH081J_shinsa.pdf 審査結果の要旨 (111.3 kB)
13MH081J_ronbun.pdf 博士論文の全文 (1.5 MB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2018-06-28
タイトル
言語 en
タイトル SIRT1 regulates the chemoresistance, and invasiveness of ovarian carcinoma cells(SIRT1は卵巣癌細胞の抗がん剤耐性および浸潤能を調節する)
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_db06
タイプ doctoral thesis
著者 MVUNTA, DAVID HAMISI

× MVUNTA, DAVID HAMISI

WEKO 105901

MVUNTA, DAVID HAMISI

Search repository
出版者
出版者 信州大学
引用
内容記述タイプ Other
内容記述 MVUNTA DAVID HAMISI. SIRT1 regulates the chemoresistance, and invasiveness of ovarian carcinoma cells(SIRT1は卵巣癌細胞の抗がん剤耐性および浸潤能を調節する). 信州大学, 2017, 博士論文.
書誌情報
発行日 2017-09-30
学位授与番号
学位授与番号 13601甲第1103号
学位授与年月日
学位授与年月日 2017-09-30
学位名
学位名 博士(医学)
学位授与機関
学位授与機関名
学位授与機関名 信州大学(Shinshu university)
学位の区分
Doctoral
学位の分野
医学
学位の報告番号
甲第1103号
内容記述
内容記述タイプ Other
内容記述 雑誌に発表。TRANSLATIONAL ONCOLOGY. 10(4):621-631 (2017); doi:10.1016/j.tranon.2017.05.005.
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Thesis
PubMed
関連識別子
識別子タイプ PMID
関連識別子 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search&DB=pubmed&term=28667895
関連名称
関連名称 28667895
DOI
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1016/j.tranon.2017.05.005
関連名称
関連名称 10.1016/j.tranon.2017.05.005
権利
権利情報 © 2017 The Authors. Published by Elsevier Inc. on behalf of Neoplasia Press, Inc.
出版タイプ
出版タイプ NA
出版タイプResource http://purl.org/coar/version/c_be7fb7dd8ff6fe43
WoS
Web of Science
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000407707700018
戻る
0
views
See details
Views

Versions

Ver.1 2021-03-01 08:22:31.542520
Show All versions

Share

Mendeley CiteULike Twitter Facebook Print Addthis

Cite as

Export

OAI-PMH
  • OAI-PMH JPCOAR
  • OAI-PMH DublinCore
  • OAI-PMH DDI
Other Formats
  • JSON
  • BIBTEX

Confirm


Powered by CERN Data Centre & Invenio


Powered by CERN Data Centre & Invenio