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Methods: We retrospectively analyzed the clinical outcomes after initiating treatment in 66 patients with PM/DM (28 PM and 38 DM). After initiating treatment, the prognosis was compared between patients who received TAC in combination with prednisolone (PSL) (the concomitant TAC group), and patients who were treated with PSL alone. The therapeutic efficacy of TAC was also evaluated for patients in the concomitant TAC group as well as patients who started additional TAC treatment after relapse (the additional TAC group), by analyzing clinical results, including serum creatine kinase (CK) levels, muscle strength and the daily dose of PSL. Results: Patients in the concomitant TAC group had significantly lower frequency of relapse and longer periods of remission than patients who were treated with PSL alone (P = 0.0001, P = 0.001, respectively). Significant decreases in CK levels were observed 1 month after starting TAC treatment in both the concomitant TAC group and the additional TAC group. Moreover, the significant effects of withdrawing PSL were also demonstrated in both groups. Conclusion: Concomitant use of TAC with PSL clearly provides a favorable outcome in patients with DM/PM. 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  1. 050 医学部, 大学院医学系研究科
  2. 0507 学位論文
  3. 博士(医学)

Advantage of administering tacrolimus for improving prognosis of patients with polymyositis and dermatomyositis(多発性筋炎および皮膚筋炎患者における予後改善のためのタクロリムス導入の有用性)

http://hdl.handle.net/10091/00020718
8a6067e4-6eb2-4ab1-9a32-3d7e9d317f72
名前 / ファイル ライセンス アクション
14MH202E_yoshi.pdf 内容の要旨 (169.1 kB)
14MH202E_shinsa.pdf 審査結果の要旨 (92.2 kB)
14MH202E_ronbun.pdf 博士論文の全文 (210.8 kB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2018-06-28
タイトル
言語 en
タイトル Advantage of administering tacrolimus for improving prognosis of patients with polymyositis and dermatomyositis(多発性筋炎および皮膚筋炎患者における予後改善のためのタクロリムス導入の有用性)
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_db06
タイプ doctoral thesis
著者 上野, 賢一

× 上野, 賢一

WEKO 105910

上野, 賢一

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出版者
出版者 信州大学
引用
内容記述タイプ Other
内容記述 上野 賢一. Advantage of administering tacrolimus for improving prognosis of patients with polymyositis and dermatomyositis(多発性筋炎および皮膚筋炎患者における予後改善のためのタクロリムス導入の有用性). 信州大学, 2018, 博士論文.
書誌情報
発行日 2018-03-31
学位授与番号
学位授与番号 13601甲第1112号
学位授与年月日
学位授与年月日 2018-03-31
学位名
学位名 博士(医学)
学位授与機関
学位授与機関名
学位授与機関名 信州大学(Shinshu university)
学位の区分
Doctoral
学位の分野
医学
学位の報告番号
甲第1112号
内容記述
内容記述タイプ Other
内容記述 雑誌に発表。INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES. 19(12):1322-1330 (2016); doi:10.1111/1756-185X.12931.
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Thesis
PubMed
関連識別子
識別子タイプ PMID
関連識別子 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search&DB=pubmed&term=27457756
関連名称
関連名称 27457756
DOI
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1111/1756-185X.12931
関連名称
関連名称 10.1111/1756-185X.12931
権利
権利情報 This is the peer reviewed version of the following article: Ueno, K. , Shimojima, Y. , Kishida, D. , Sekijima, Y. and Ikeda, S. (2016), Advantage of administering tacrolimus for improving prognosis of patients with polymyositis and dermatomyositis. Int J Rheum Dis, 19: 1322-1330. doi:10.1111/1756-185X.12931, which has been published in final form at https://doi.org/10.1111/1756-185X.12931 . This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
出版タイプ
出版タイプ NA
出版タイプResource http://purl.org/coar/version/c_be7fb7dd8ff6fe43
WoS
Web of Science
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000398230800015
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