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Originally identified as a strong vasodilatory and hypotensive peptide, CGRP is now known to be a pleiotropic molecule distributed in various organs, including the brain.Method:In this study, we used CGRP knockout mice (CGRP-/-) to examine the actions of endogenous CGRP during cerebral ischemia. To induce acute and chronic cerebral ischemia, mice were subjected to middle cerebral artery occlusion (MCAO) and bilateral common carotid artery stenosis (BCAS).Results:In the cerebral cortex of wild-type mice, CGRP expression was upregulated after acute infarction. In CGRP-/- subjected to MCAO or BCAS, recovery of cerebral blood flow was slower and exhibited more extensive neuronal cell death. Expression of the inflammatory cytokines was higher in CGRP-/- than wild type in the acute phase of ischemia. Pathological analysis during the chronic phase revealed more extensive neuronal cell loss and demyelination and higher levels of oxidative stress in CGRP-/- than wild-type. 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  1. 050 医学部, 大学院医学系研究科
  2. 0507 学位論文
  3. 博士(医学)

Endogenous calcitonin gene-related peptide suppresses ischemic brain injuries and progression of cognitive decline(カルシトニン遺伝子関連ペプチド(CGRP)は、虚血性脳障害および認知機能障害の進展を抑制する)

http://hdl.handle.net/10091/00020721
affdc468-ffdc-46c2-bc14-84809ed0b182
名前 / ファイル ライセンス アクション
14MH206H_yoshi.pdf 内容の要旨 (140.5 kB)
14MH206H_shinsa.pdf 審査結果の要旨 (108.7 kB)
14MH206H_ronbun.pdf 博士論文の全文 (2.6 MB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2018-06-28
タイトル
言語 en
タイトル Endogenous calcitonin gene-related peptide suppresses ischemic brain injuries and progression of cognitive decline(カルシトニン遺伝子関連ペプチド(CGRP)は、虚血性脳障害および認知機能障害の進展を抑制する)
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_db06
タイプ doctoral thesis
著者 翟, 留玉

× 翟, 留玉

WEKO 105913

翟, 留玉

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出版者
出版者 信州大学
引用
内容記述タイプ Other
内容記述 翟 留玉. Endogenous calcitonin gene-related peptide suppresses ischemic brain injuries and progression of cognitive decline(カルシトニン遺伝子関連ペプチド(CGRP)は、虚血性脳障害および認知機能障害の進展を抑制する). 信州大学, 2018, 博士論文.
書誌情報
発行日 2018-03-31
学位授与番号
学位授与番号 13601甲第1115号
学位授与年月日
学位授与年月日 2018-03-31
学位名
学位名 博士(医学)
学位授与機関
学位授与機関名
学位授与機関名 信州大学(Shinshu university)
学位の区分
Doctoral
学位の分野
医学
学位の報告番号
甲第1115号
内容記述
内容記述タイプ Other
内容記述 雑誌に発表。JOURNAL OF HYPERTENSION. 36(4):876-891 (2018); doi:10.1097/HJH.0000000000001649.
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Thesis
PubMed
関連識別子
識別子タイプ PMID
関連識別子 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search&DB=pubmed&term=29266061
関連名称
関連名称 29266061
DOI
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1097/HJH.0000000000001649
関連名称
関連名称 10.1097/HJH.0000000000001649
権利
権利情報 © 2018 Wolters Kluwer Health, Inc.
出版タイプ
出版タイプ NA
出版タイプResource http://purl.org/coar/version/c_be7fb7dd8ff6fe43
WoS
Web of Science
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000427994500023
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