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Controlled attenuation parameter is correlated with actual hepatic fat content in patients with non-alcoholic fatty liver disease with none-to-mild obesity and liver fibrosis(肥満・肝線維化が無-軽度の非アルコール性脂肪性肝疾患患者では、減衰制御パラメータが実際の肝脂肪量と相関する). 信州大学, 2018, 博士論文.", "subitem_description_type": "Other"}]}, "item_14_dissertation_number_7": {"attribute_name": "学位授与番号", "attribute_value_mlt": [{"subitem_dissertationnumber": "13601甲第1118号"}]}, "item_14_link_74": {"attribute_name": "WoS", "attribute_value_mlt": [{"subitem_link_text": "Web of Science", "subitem_link_url": "http://gateway.isiknowledge.com/gateway/Gateway.cgi?\u0026GWVersion=2\u0026SrcAuth=ShinshuUniv\u0026SrcApp=ShinshuUniv\u0026DestLinkType=FullRecord\u0026DestApp=WOS\u0026KeyUT=000383719600008"}]}, "item_14_publisher_4": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "信州大学"}]}, "item_14_relation_54": {"attribute_name": "PubMed", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "27183219"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://pubmed.ncbi.nlm.nih.gov/27183219/", "subitem_relation_type_select": "PMID"}}]}, "item_14_relation_55": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "10.1111/hepr.12649"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1111/hepr.12649", "subitem_relation_type_select": "DOI"}}]}, "item_14_rights_69": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "© 2016 The Japan Society of Hepatology / This is the peer reviewed version of the following article: Fujimori, N., Tanaka, N., Shibata, S., Sano, K., Yamazaki, T., Sekiguchi, T., Kitabatake, H., Ichikawa, Y., Kimura, T., Komatsu, M., Umemura, T., Matsumoto, A., and Tanaka, E. (2016) Controlled attenuation parameter is correlated with actual hepatic fat content in patients with non‐alcoholic fatty liver disease with none‐to‐mild obesity and liver fibrosis. Hepatol Res, 46: 1019–1027. doi: 10.1111/hepr.12649, which has been published in final form at https://doi.org/10.1111/hepr.12649 . This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. "}]}, "item_14_select_71": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "ETD"}]}, "item_14_text_11": {"attribute_name": "学位の区分", "attribute_value_mlt": [{"subitem_text_value": "doctoral"}]}, "item_14_text_12": {"attribute_name": "学位の分野", "attribute_value_mlt": [{"subitem_text_value": "医学"}]}, "item_14_text_13": {"attribute_name": "学位の報告番号", "attribute_value_mlt": [{"subitem_text_value": "甲第1118号"}]}, "item_14_text_76": {"attribute_name": "wosonly authkey", "attribute_value_mlt": [{"subitem_text_value": "body mass index; controlled attenuation parameter; fibrosis; liver fat; non-alcoholic fatty liver disease"}]}, "item_14_text_77": {"attribute_name": "wosonly keywords", "attribute_value_mlt": [{"subitem_text_value": "TRANSIENT ELASTOGRAPHY; NONINVASIVE METHOD; DOWN-REGULATION; SCORING SYSTEM; STEATOSIS; STEATOHEPATITIS; DIAGNOSIS; STIFFNESS; BIOPSY; CAP"}]}, "item_14_textarea_75": {"attribute_name": "wosonly abstract", "attribute_value_mlt": [{"subitem_textarea_value": "Aim: Non-invasive steatosis-quantifying methods are required for non-alcoholic fatty liver disease (NAFLD) patients in order to monitor disease severity and assess therapeutic efficacy. Controlled attenuation parameter (CAP) evaluated with vibration-controlled transient elastography can predict the presence of steatosis, but its application to absolute hepatic fat quantitation remains unclear. The aim of this st\\udy was to examine whether CAP is correlated with real hepatic fat content in NAFLD patients. MethodsEighty-two NAFLD patients who had undergone percutaneous liver biopsy were enrolled. CAP was measured using FibroScan((R)) just before liver biopsy. The percentage of fat droplet area to hepatocyte area in biopsied specimen was determined morphometrically using computerized optical image analyzing system. The correlation between CAP and liver histology was examined. ResultsCAP showed an excellent correlation with actual liver fat percentage in the NAFLD patients with body mass index (BMI) of less than 28kg/m(2) (r=0.579, P\u003c0.0001), especially less than 25kg/m(2) (r=0.708, P\u003c0.01), but the meaningful correlation disappeared in the patients with BMI of 28kg/m(2) or more. In the patients with BMI of less than 28kg/m(2), CAP quantitativeness was affected by the presence of stage 2-4 fibrosis, but not the presence of hepatocyte ballooning and severity of lobular inflammation. ConclusionCAP may be a promising tool for quantifying hepatic fat content in NAFLD patients with none-to-mild obesity and liver fibrosis. Further improvement of CAP performance is needed for the NAFLD patients with BMI of more than 28kg/m(2) or significant hepatic fibrosis."}]}, "item_1627890986942": {"attribute_name": "出版タイプ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_be7fb7dd8ff6fe43", "subitem_version_type": "NA"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "open access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_abf2"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "藤森, 尚之", "creatorNameLang": "ja"}], "nameIdentifiers": [{"nameIdentifier": "105916", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-06-28"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "14MH040E_yoshi.pdf", "filesize": [{"value": "110.9 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 110900.0, "url": {"label": "内容の要旨", "url": "https://soar-ir.repo.nii.ac.jp/record/19963/files/14MH040E_yoshi.pdf"}, "version_id": "c6e91473-95b4-4e8f-b6f0-436d9d2a239e"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-06-28"}], "displaytype": "detail", "download_preview_message": "", "file_order": 1, "filename": "14MH040E_shinsa.pdf", "filesize": [{"value": "117.4 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 117400.0, "url": {"label": "審査結果の要旨", "url": "https://soar-ir.repo.nii.ac.jp/record/19963/files/14MH040E_shinsa.pdf"}, "version_id": "96b5000c-2071-4a03-995e-20247fbba608"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-06-28"}], "displaytype": "detail", "download_preview_message": "", "file_order": 2, "filename": "14MH040E_ronbun.pdf", "filesize": [{"value": "392.9 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensefree": "© 2016 The Japan Society of Hepatology / This is the peer reviewed version of the following article: Fujimori, N., Tanaka, N., Shibata, S., Sano, K., Yamazaki, T., Sekiguchi, T., Kitabatake, H., Ichikawa, Y., Kimura, T., Komatsu, M., Umemura, T., Matsumoto, A., and Tanaka, E. (2016) Controlled attenuation parameter is correlated with actual hepatic fat content in patients with non‐alcoholic fatty liver disease with none‐to‐mild obesity and liver fibrosis. Hepatol Res, 46: 1019–1027. doi: 10.1111/hepr.12649, which has been published in final form at https://doi.org/10.1111/hepr.12649 . 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Controlled attenuation parameter is correlated with actual hepatic fat content in patients with non-alcoholic fatty liver disease with none-to-mild obesity and liver fibrosis(肥満・肝線維化が無-軽度の非アルコール性脂肪性肝疾患患者では、減衰制御パラメータが実際の肝脂肪量と相関する)
http://hdl.handle.net/10091/00020724
http://hdl.handle.net/10091/000207242230d2e5-d06b-471f-aec4-418a16710c90
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内容の要旨 (110.9 kB)
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審査結果の要旨 (117.4 kB)
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博士論文の全文 (392.9 kB)
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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公開日 | 2018-06-28 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Controlled attenuation parameter is correlated with actual hepatic fat content in patients with non-alcoholic fatty liver disease with none-to-mild obesity and liver fibrosis(肥満・肝線維化が無-軽度の非アルコール性脂肪性肝疾患患者では、減衰制御パラメータが実際の肝脂肪量と相関する) | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_db06 | |||||
タイプ | doctoral thesis | |||||
アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
著者 |
藤森, 尚之
× 藤森, 尚之 |
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出版者 | ||||||
出版者 | 信州大学 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 藤森 尚之. Controlled attenuation parameter is correlated with actual hepatic fat content in patients with non-alcoholic fatty liver disease with none-to-mild obesity and liver fibrosis(肥満・肝線維化が無-軽度の非アルコール性脂肪性肝疾患患者では、減衰制御パラメータが実際の肝脂肪量と相関する). 信州大学, 2018, 博士論文. | |||||
書誌情報 |
発行日 2018-03-31 |
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学位授与番号 | ||||||
学位授与番号 | 13601甲第1118号 | |||||
学位授与年月日 | ||||||
学位授与年月日 | 2018-03-31 | |||||
学位名 | ||||||
学位名 | 博士(医学) | |||||
学位授与機関 | ||||||
学位授与機関識別子Scheme | kakenhi | |||||
学位授与機関識別子 | 13601 | |||||
学位授与機関名 | 信州大学(Shinshu university) | |||||
学位の区分 | ||||||
doctoral | ||||||
学位の分野 | ||||||
医学 | ||||||
学位の報告番号 | ||||||
甲第1118号 | ||||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 雑誌に発表。HEPATOLOGY RESEARCH. 46(10):1019-1027 (2016); doi:10.1111/hepr.12649. | |||||
資源タイプ(コンテンツの種類) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Thesis | |||||
PubMed | ||||||
識別子タイプ | PMID | |||||
関連識別子 | https://pubmed.ncbi.nlm.nih.gov/27183219/ | |||||
関連名称 | 27183219 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1111/hepr.12649 | |||||
関連名称 | 10.1111/hepr.12649 | |||||
権利 | ||||||
権利情報 | © 2016 The Japan Society of Hepatology / This is the peer reviewed version of the following article: Fujimori, N., Tanaka, N., Shibata, S., Sano, K., Yamazaki, T., Sekiguchi, T., Kitabatake, H., Ichikawa, Y., Kimura, T., Komatsu, M., Umemura, T., Matsumoto, A., and Tanaka, E. (2016) Controlled attenuation parameter is correlated with actual hepatic fat content in patients with non‐alcoholic fatty liver disease with none‐to‐mild obesity and liver fibrosis. Hepatol Res, 46: 1019–1027. doi: 10.1111/hepr.12649, which has been published in final form at https://doi.org/10.1111/hepr.12649 . This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. | |||||
出版タイプ | ||||||
出版タイプ | NA | |||||
出版タイプResource | http://purl.org/coar/version/c_be7fb7dd8ff6fe43 | |||||
WoS | ||||||
Web of Science | ||||||
URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000383719600008 |