ログイン
言語:

WEKO3

  • トップ
  • ランキング
To
lat lon distance
To

Field does not validate



インデックスリンク

インデックスツリー

メールアドレスを入力してください。

WEKO

One fine body…

WEKO

One fine body…

アイテム

{"_buckets": {"deposit": "5d094978-a934-4c06-81bd-f8e8b2c734fc"}, "_deposit": {"id": "19970", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "19970"}, "status": "published"}, "_oai": {"id": "oai:soar-ir.repo.nii.ac.jp:00019970", "sets": ["849"]}, "author_link": ["105923"], "item_14_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2017-03-31", "bibliographicIssueDateType": "Issued"}}]}, "item_14_date_granted_8": {"attribute_name": "学位授与年月日", "attribute_value_mlt": [{"subitem_dategranted": "2017-03-31"}]}, "item_14_degree_grantor_10": {"attribute_name": "学位授与機関", "attribute_value_mlt": [{"subitem_degreegrantor": [{"subitem_degreegrantor_name": "信州大学(Shinshu university)"}]}]}, "item_14_degree_name_9": {"attribute_name": "学位名", "attribute_value_mlt": [{"subitem_degreename": "博士(医学)"}]}, "item_14_description_26": {"attribute_name": "内容記述", "attribute_value_mlt": [{"subitem_description": "雑誌に発表。PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY. 470(6):909-921 (2018); doi:10.1007/s00424-018-2114-3.", "subitem_description_type": "Other"}]}, "item_14_description_37": {"attribute_name": "資源タイプ(コンテンツの種類)", "attribute_value_mlt": [{"subitem_description": "Thesis", "subitem_description_type": "Other"}]}, "item_14_description_5": {"attribute_name": "引用", "attribute_value_mlt": [{"subitem_description": "郭 暁光. PDGF-induced migration of synthetic vascular smooth muscle cells through c-Src-activated L-type Ca2+ channels with full-length CaV1.2 C-terminus(血小板由来増殖因子による合成型血管平滑筋細胞の遊走は、c-Srcで活性化された全長型Cav1.2 C末端を有するL型Ca2+チャネルを介する). 信州大学, 2017, 博士論文.", "subitem_description_type": "Other"}]}, "item_14_dissertation_number_7": {"attribute_name": "学位授与番号", "attribute_value_mlt": [{"subitem_dissertationnumber": "13601甲第1125号"}]}, "item_14_link_74": {"attribute_name": "WoS", "attribute_value_mlt": [{"subitem_link_text": "Web of Science", "subitem_link_url": "http://gateway.isiknowledge.com/gateway/Gateway.cgi?\u0026GWVersion=2\u0026SrcAuth=ShinshuUniv\u0026SrcApp=ShinshuUniv\u0026DestLinkType=FullRecord\u0026DestApp=WOS\u0026KeyUT=000431873800005"}]}, "item_14_publisher_4": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "信州大学"}]}, "item_14_relation_54": {"attribute_name": "PubMed", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "29441404"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search\u0026DB=pubmed\u0026term=29441404", "subitem_relation_type_select": "PMID"}}]}, "item_14_relation_55": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "10.1007/s00424-018-2114-3"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1007/s00424-018-2114-3", "subitem_relation_type_select": "DOI"}}]}, "item_14_rights_69": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "The final publication is available at link.springer.com"}]}, "item_14_select_71": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "ETD"}]}, "item_14_text_11": {"attribute_name": "学位の区分", "attribute_value_mlt": [{"subitem_text_value": "Doctoral"}]}, "item_14_text_12": {"attribute_name": "学位の分野", "attribute_value_mlt": [{"subitem_text_value": "医学"}]}, "item_14_text_13": {"attribute_name": "学位の報告番号", "attribute_value_mlt": [{"subitem_text_value": "甲第1125号"}]}, "item_14_text_76": {"attribute_name": "wosonly authkey", "attribute_value_mlt": [{"subitem_text_value": "Vascular smooth muscle cells; Platelet-derived growth factor; Ca(V)1.2 channels; c-Src"}]}, "item_14_text_77": {"attribute_name": "wosonly keywords", "attribute_value_mlt": [{"subitem_text_value": "HIGH BLOOD-PRESSURE; CALCIUM-CHANNELS; SUBUNIT; KINASE; TRANSCRIPTION; CHEMOTAXIS; MECHANISMS; ARTERIES; DOMAIN"}]}, "item_14_textarea_75": {"attribute_name": "wosonly abstract", "attribute_value_mlt": [{"subitem_textarea_value": "In atherosclerosis, vascular smooth muscle cells (VSMC) migrate from the media toward the intima of the arteries in response to cytokines, such as platelet-derived growth factor (PDGF). However, molecular mechanism underlying the PDGF-induced migration of VSMCs remains unclear. The migration of rat aorta-derived synthetic VSMCs, A7r5, in response to PDGF was potently inhibited by a Ca(V)1.2 channel inhibitor, nifedipine, and a Src family tyrosine kinase (SFK)/Abl inhibitor, bosutinib, in a less-than-additive manner. PDGF significantly increased Ca(V)1.2 channel currents without altering Ca(V)1.2 protein expression levels in A7r5 cells. This reaction was inhibited by C-terminal Src kinase, a selective inhibitor of SFKs. In contractile VSMCs, the C-terminus of Ca(V)1.2 is proteolytically cleaved into proximal and distal C-termini (PCT and DCT, respectively). Clipped DCT is noncovalently reassociated with PCT to autoinhibit the channel activity. Conversely, in synthetic A7r5 cells, full-length Ca(V)1.2 (Ca(V)1.2FL) is expressed much more abundantly than truncated Ca(V)1.2. In a heterologous expression system, c-Src activated Ca(V)1.2 channels composed of Ca(V)1.2FL but not truncated Ca(V)1.2 (Ca(V)1.2 Delta 1763) or Ca(V)1.2 Delta 1763 plus clipped DCT. Further, c-Src enhanced the coupling efficiency between the voltage-sensing domain and activation gate of Ca(V)1.2FL channels by phosphorylating Tyr1709 and Tyr1758 in PCT. Compared with Ca(V)1.2 Delta 1763, c-Src could more efficiently bind to and phosphorylate Ca(V)1.2FL irrespective of the presence or absence of clipped DCT. Therefore, in atherosclerotic lesions, phenotypic switching of VSMCs may facilitate pro-migratory effects of PDGF on VSMCs by suppressing posttranslational Ca(V)1.2 modifications."}]}, "item_1627890986942": {"attribute_name": "出版タイプ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_be7fb7dd8ff6fe43", "subitem_version_type": "NA"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "郭, 暁光"}], "nameIdentifiers": [{"nameIdentifier": "105923", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-06-28"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "13MH205F_yoshi.pdf", "filesize": [{"value": "123.8 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 123800.0, "url": {"label": "内容の要旨", "url": "https://soar-ir.repo.nii.ac.jp/record/19970/files/13MH205F_yoshi.pdf"}, "version_id": "a6c1d2d3-d06a-48c3-b44d-6d118a852117"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-06-28"}], "displaytype": "detail", "download_preview_message": "", "file_order": 1, "filename": "13MH205F_shinsa.pdf", "filesize": [{"value": "134.8 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 134800.0, "url": {"label": "審査結果の要旨", "url": "https://soar-ir.repo.nii.ac.jp/record/19970/files/13MH205F_shinsa.pdf"}, "version_id": "75fc24e7-530a-4287-9b2d-060eb599026f"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-02-13"}], "displaytype": "detail", "download_preview_message": "", "file_order": 2, "filename": "13MH205F_ronbun.pdf", "filesize": [{"value": "1.7 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensefree": "The final publication is available at link.springer.com", "licensetype": "license_note", "mimetype": "application/pdf", "size": 1700000.0, "url": {"label": "博士論文の全文", "url": "https://soar-ir.repo.nii.ac.jp/record/19970/files/13MH205F_ronbun.pdf"}, "version_id": "c5f5b549-686c-4c57-b40d-400be78b744c"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "doctoral thesis", "resourceuri": "http://purl.org/coar/resource_type/c_db06"}]}, "item_title": "PDGF-induced migration of synthetic vascular smooth muscle cells through c-Src-activated L-type Ca2+ channels with full-length CaV1.2 C-terminus(血小板由来増殖因子による合成型血管平滑筋細胞の遊走は、c-Srcで活性化された全長型Cav1.2 C末端を有するL型Ca2+チャネルを介する)", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "PDGF-induced migration of synthetic vascular smooth muscle cells through c-Src-activated L-type Ca2+ channels with full-length CaV1.2 C-terminus(血小板由来増殖因子による合成型血管平滑筋細胞の遊走は、c-Srcで活性化された全長型Cav1.2 C末端を有するL型Ca2+チャネルを介する)", "subitem_title_language": "en"}]}, "item_type_id": "14", "owner": "1", "path": ["849"], "permalink_uri": "http://hdl.handle.net/10091/00020731", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2018-06-28"}, "publish_date": "2018-06-28", "publish_status": "0", "recid": "19970", "relation": {}, "relation_version_is_last": true, "title": ["PDGF-induced migration of synthetic vascular smooth muscle cells through c-Src-activated L-type Ca2+ channels with full-length CaV1.2 C-terminus(血小板由来増殖因子による合成型血管平滑筋細胞の遊走は、c-Srcで活性化された全長型Cav1.2 C末端を有するL型Ca2+チャネルを介する)"], "weko_shared_id": -1}
  1. 050 医学部, 大学院医学系研究科
  2. 0507 学位論文
  3. 博士(医学)

PDGF-induced migration of synthetic vascular smooth muscle cells through c-Src-activated L-type Ca2+ channels with full-length CaV1.2 C-terminus(血小板由来増殖因子による合成型血管平滑筋細胞の遊走は、c-Srcで活性化された全長型Cav1.2 C末端を有するL型Ca2+チャネルを介する)

http://hdl.handle.net/10091/00020731
http://hdl.handle.net/10091/00020731
64438590-7964-4c19-8e2b-e8b2301b36f4
名前 / ファイル ライセンス アクション
13MH205F_yoshi.pdf 内容の要旨 (123.8 kB)
13MH205F_shinsa.pdf 審査結果の要旨 (134.8 kB)
13MH205F_ronbun.pdf 博士論文の全文 (1.7 MB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2018-06-28
タイトル
言語 en
タイトル PDGF-induced migration of synthetic vascular smooth muscle cells through c-Src-activated L-type Ca2+ channels with full-length CaV1.2 C-terminus(血小板由来増殖因子による合成型血管平滑筋細胞の遊走は、c-Srcで活性化された全長型Cav1.2 C末端を有するL型Ca2+チャネルを介する)
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_db06
タイプ doctoral thesis
著者 郭, 暁光

× 郭, 暁光

WEKO 105923

郭, 暁光

Search repository
出版者
出版者 信州大学
引用
内容記述タイプ Other
内容記述 郭 暁光. PDGF-induced migration of synthetic vascular smooth muscle cells through c-Src-activated L-type Ca2+ channels with full-length CaV1.2 C-terminus(血小板由来増殖因子による合成型血管平滑筋細胞の遊走は、c-Srcで活性化された全長型Cav1.2 C末端を有するL型Ca2+チャネルを介する). 信州大学, 2017, 博士論文.
書誌情報
発行日 2017-03-31
学位授与番号
学位授与番号 13601甲第1125号
学位授与年月日
学位授与年月日 2017-03-31
学位名
学位名 博士(医学)
学位授与機関
学位授与機関名 信州大学(Shinshu university)
学位の区分
Doctoral
学位の分野
医学
学位の報告番号
甲第1125号
内容記述
内容記述タイプ Other
内容記述 雑誌に発表。PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY. 470(6):909-921 (2018); doi:10.1007/s00424-018-2114-3.
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Thesis
PubMed
識別子タイプ PMID
関連識別子 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search&DB=pubmed&term=29441404
関連名称 29441404
DOI
識別子タイプ DOI
関連識別子 https://doi.org/10.1007/s00424-018-2114-3
関連名称 10.1007/s00424-018-2114-3
権利
権利情報 The final publication is available at link.springer.com
出版タイプ
出版タイプ NA
出版タイプResource http://purl.org/coar/version/c_be7fb7dd8ff6fe43
WoS
Web of Science
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000431873800005
戻る
0
views
See details
Views

Versions

Ver.1 2021-03-01 07:53:13.812352
Show All versions

Share

Mendeley Twitter Facebook Print Addthis

Cite as

エクスポート

OAI-PMH
  • OAI-PMH JPCOAR
  • OAI-PMH DublinCore
  • OAI-PMH DDI
Other Formats
  • JSON
  • BIBTEX

Confirm


Powered by WEKO3


Powered by WEKO3