ログイン
言語:

WEKO3

  • トップ
  • コミュニティ
  • ランキング
AND
To
lat lon distance
To

Field does not validate



インデックスリンク

インデックスツリー

メールアドレスを入力してください。

WEKO

One fine body…

WEKO

One fine body…

アイテム

{"_buckets": {"deposit": "bf39a151-7a92-4971-93d4-f89766ea6c4d"}, "_deposit": {"id": "19976", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "19976"}, "status": "published"}, "_oai": {"id": "oai:soar-ir.repo.nii.ac.jp:00019976", "sets": []}, "author_link": ["105929"], "item_14_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2018-03-31", "bibliographicIssueDateType": "Issued"}}]}, "item_14_date_granted_8": {"attribute_name": "\u5b66\u4f4d\u6388\u4e0e\u5e74\u6708\u65e5", "attribute_value_mlt": [{"subitem_dategranted": "2018-03-31"}]}, "item_14_degree_grantor_10": {"attribute_name": "\u5b66\u4f4d\u6388\u4e0e\u6a5f\u95a2", "attribute_value_mlt": [{"subitem_degreegrantor": [{"subitem_degreegrantor_name": "\u4fe1\u5dde\u5927\u5b66(Shinshu university)"}]}]}, "item_14_degree_name_9": {"attribute_name": "\u5b66\u4f4d\u540d", "attribute_value_mlt": [{"subitem_degreename": "\u535a\u58eb\uff08\u533b\u5b66\uff09"}]}, "item_14_description_26": {"attribute_name": "\u5185\u5bb9\u8a18\u8ff0", "attribute_value_mlt": [{"subitem_description": "\u96d1\u8a8c\u306b\u767a\u8868\u3002JOURNAL OF BIOLOGICAL CHEMISTRY. 293(17):6326-6336 (2018); doi:10.1074/jbc.M117.819201.", "subitem_description_type": "Other"}]}, "item_14_description_37": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7\uff08\u30b3\u30f3\u30c6\u30f3\u30c4\u306e\u7a2e\u985e\uff09", "attribute_value_mlt": [{"subitem_description": "Thesis", "subitem_description_type": "Other"}]}, "item_14_description_5": {"attribute_name": "\u5f15\u7528", "attribute_value_mlt": [{"subitem_description": "\u677e\u6751\u3000\u5bcc\u7a42. Fascin1 supresses RIG-I-like receptor signaling and interferon-\u03b2 production by associating with I\u03baB kinase \u03b5(IKK\u03b5) in colon cancer\uff08RIG-I\u7d4c\u8def\u3092\u4ecb\u3057\u305fFascin1\u306b\u3088\u308bIFN-\u03b2\u6291\u5236\u5236\u5fa1\uff09. \u4fe1\u5dde\u5927\u5b66, 2018, \u535a\u58eb\u8ad6\u6587.", "subitem_description_type": "Other"}]}, "item_14_dissertation_number_7": {"attribute_name": "\u5b66\u4f4d\u6388\u4e0e\u756a\u53f7", "attribute_value_mlt": [{"subitem_dissertationnumber": "13601\u7532\u7b2c1133\u53f7"}]}, "item_14_link_74": {"attribute_name": "WoS", "attribute_value_mlt": [{"subitem_link_text": "Web of Science", "subitem_link_url": "http://gateway.isiknowledge.com/gateway/Gateway.cgi?\u0026GWVersion=2\u0026SrcAuth=ShinshuUniv\u0026SrcApp=ShinshuUniv\u0026DestLinkType=FullRecord\u0026DestApp=WOS\u0026KeyUT=000431108600009"}]}, "item_14_publisher_4": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "\u4fe1\u5dde\u5927\u5b66"}]}, "item_14_relation_54": {"attribute_name": "PubMed", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "29496994"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search\u0026DB=pubmed\u0026term=29496994", "subitem_relation_type_select": "PMID"}}]}, "item_14_relation_55": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "10.1074/jbc.M117.819201"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1074/jbc.M117.819201", "subitem_relation_type_select": "DOI"}}]}, "item_14_rights_69": {"attribute_name": "\u6a29\u5229", "attribute_value_mlt": [{"subitem_rights": "This research was originally published in J. Biol. Chem. Tomio Matsumura, Shigeaki Hida, Masato Kitazawa, Chifumi Fujii, Akira Kobayashi, Michiko Takeoka, Shun-ichiro Taniguchi, Shin-ichi Miyagawa. Fascin1 suppresses RIG-I\u2013like receptor signaling and interferon-\u03b2 production by associating with I\u03baB kinase \u03f5 (IKK\u03f5) in colon cancer. J. Biol. Chem. 2018; Vol. 293:6326. \u00a9 the American Society for Biochemistry and Molecular Biology. "}]}, "item_14_select_71": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "ETD"}]}, "item_14_text_11": {"attribute_name": "\u5b66\u4f4d\u306e\u533a\u5206", "attribute_value_mlt": [{"subitem_text_value": "Doctoral"}]}, "item_14_text_12": {"attribute_name": "\u5b66\u4f4d\u306e\u5206\u91ce", "attribute_value_mlt": [{"subitem_text_value": "\u533b\u5b66"}]}, "item_14_text_13": {"attribute_name": "\u5b66\u4f4d\u306e\u5831\u544a\u756a\u53f7", "attribute_value_mlt": [{"subitem_text_value": "\u7532\u7b2c1133\u53f7"}]}, "item_14_text_76": {"attribute_name": "wosonly authkey", "attribute_value_mlt": [{"subitem_text_value": "interferon; interferon regulatory factor (IRF); invasion; RIG-I-like receptor (RLR); signal transducers and activators of transcription 1 (STAT1); IB Kinase E fascin1; poly(I.C)"}]}, "item_14_text_77": {"attribute_name": "wosonly keywords", "attribute_value_mlt": [{"subitem_text_value": "CELL-PROLIFERATION; VIRUS-INFECTION; PROTEIN TANK; IFN-BETA; ACTIVATION; EXPRESSION; STAT1; METASTASIS; TARGET; DOMAIN"}]}, "item_14_textarea_75": {"attribute_name": "wosonly abstract", "attribute_value_mlt": [{"subitem_textarea_value": "Fascin1 is an actin-bundling protein involved in cancer cell migration and has recently been shown also to have roles in virus-mediated immune cell responses. Because viral infection has been shown to activate immune cells and to induce interferon-beta expression in human cancer cells, we evaluated the effects of fascin1 on virus-dependent signaling via the membrane- and actin-associated protein RIG-I (retinoic acid-inducible gene I) in colon cancer cells. We knocked down fascin1 expression with shRNA retrovirally transduced into a DLD-1 colon cancer and L929 fibroblast-like cell lines and used luciferase reporter assays and co-immunoprecipitation to identify fascin1 targets. We found that intracellular poly(I.C) transfection to mimic viral infection enhances the RIG-I/MDA5 (melanoma differentiation-associated gene 5)-mediated dimerization of interferon regulatory factor 3 (IRF-3). The transfection also significantly increased the expression levels of IRF-7, interferon-beta, and interferon-inducible cytokine IP-10 in fascin1-deleted cells compared with controls while significantly suppressing cell growth, migration, and invasion. We also found that fascin1 constitutively interacts with I kappa B kinase epsilon (IKK epsilon) in the RIG-I signaling pathway. In summary, we have identified fascin1 as a suppressor of the RIG-I signaling pathway associating with I kappa B kinase epsilon in DLD-1 colon cancer cells to suppress immune responses to viral infection."}]}, "item_1627890986942": {"attribute_name": "\u51fa\u7248\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_be7fb7dd8ff6fe43", "subitem_version_type": "NA"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "\u677e\u6751, \u5bcc\u7a42"}], "nameIdentifiers": [{"nameIdentifier": "105929", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-06-28"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "09MH203C_yoshi.pdf", "filesize": [{"value": "139.0 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 139000.0, "url": {"label": "\u5185\u5bb9\u306e\u8981\u65e8", "url": "https://soar-ir.repo.nii.ac.jp/record/19976/files/09MH203C_yoshi.pdf"}, "version_id": "00d6627b-353d-48fc-9d1b-414c7bcfa32d"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-06-28"}], "displaytype": "detail", "download_preview_message": "", "file_order": 1, "filename": "09MH203C_shinsa.pdf", "filesize": [{"value": "100.7 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 100700.0, "url": {"label": "\u5be9\u67fb\u7d50\u679c\u306e\u8981\u65e8", "url": "https://soar-ir.repo.nii.ac.jp/record/19976/files/09MH203C_shinsa.pdf"}, "version_id": "39b31b09-7e16-4c3c-92b1-eaff56fa587d"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-03-01"}], "displaytype": "detail", "download_preview_message": "", "file_order": 2, "filename": "09MH203C_ronbun.pdf", "filesize": [{"value": "760.3 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensefree": "This research was originally published in J. Biol. Chem. Tomio Matsumura, Shigeaki Hida, Masato Kitazawa, Chifumi Fujii, Akira Kobayashi, Michiko Takeoka, Shun-ichiro Taniguchi, Shin-ichi Miyagawa. Fascin1 suppresses RIG-I\u2013like receptor signaling and interferon-\u03b2 production by associating with I\u03baB kinase \u03f5 (IKK\u03f5) in colon cancer. J. Biol. Chem. 2018; Vol. 293:6326. \u00a9 the American Society for Biochemistry and Molecular Biology.", "licensetype": "license_note", "mimetype": "application/pdf", "size": 760300.0, "url": {"label": "\u535a\u58eb\u8ad6\u6587\u306e\u5168\u6587", "url": "https://soar-ir.repo.nii.ac.jp/record/19976/files/09MH203C_ronbun.pdf"}, "version_id": "e4d9d479-1231-4222-9061-c3e8d202f1d0"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "doctoral thesis", "resourceuri": "http://purl.org/coar/resource_type/c_db06"}]}, "item_title": "Fascin1 supresses RIG-I-like receptor signaling and interferon-\u03b2 production by associating with I\u03baB kinase \u03b5(IKK\u03b5) in colon cancer\uff08RIG-I\u7d4c\u8def\u3092\u4ecb\u3057\u305fFascin1\u306b\u3088\u308bIFN-\u03b2\u6291\u5236\u5236\u5fa1\uff09", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Fascin1 supresses RIG-I-like receptor signaling and interferon-\u03b2 production by associating with I\u03baB kinase \u03b5(IKK\u03b5) in colon cancer\uff08RIG-I\u7d4c\u8def\u3092\u4ecb\u3057\u305fFascin1\u306b\u3088\u308bIFN-\u03b2\u6291\u5236\u5236\u5fa1\uff09", "subitem_title_language": "en"}]}, "item_type_id": "14", "owner": "1", "path": ["461/848/849"], "permalink_uri": "http://hdl.handle.net/10091/00020737", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2018-06-28"}, "publish_date": "2018-06-28", "publish_status": "0", "recid": "19976", "relation": {}, "relation_version_is_last": true, "title": ["Fascin1 supresses RIG-I-like receptor signaling and interferon-\u03b2 production by associating with I\u03baB kinase \u03b5(IKK\u03b5) in colon cancer\uff08RIG-I\u7d4c\u8def\u3092\u4ecb\u3057\u305fFascin1\u306b\u3088\u308bIFN-\u03b2\u6291\u5236\u5236\u5fa1\uff09"], "weko_shared_id": -1}
  1. 050 医学部, 大学院医学系研究科
  2. 0507 学位論文
  3. 博士(医学)

Fascin1 supresses RIG-I-like receptor signaling and interferon-β production by associating with IκB kinase ε(IKKε) in colon cancer(RIG-I経路を介したFascin1によるIFN-β抑制制御)

http://hdl.handle.net/10091/00020737
6937fad2-867f-4e16-b38c-4148cd297fb4
名前 / ファイル ライセンス アクション
09MH203C_yoshi.pdf 内容の要旨 (139.0 kB)
09MH203C_shinsa.pdf 審査結果の要旨 (100.7 kB)
09MH203C_ronbun.pdf 博士論文の全文 (760.3 kB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2018-06-28
タイトル
言語 en
タイトル Fascin1 supresses RIG-I-like receptor signaling and interferon-β production by associating with IκB kinase ε(IKKε) in colon cancer(RIG-I経路を介したFascin1によるIFN-β抑制制御)
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_db06
タイプ doctoral thesis
著者 松村, 富穂

× 松村, 富穂

WEKO 105929

松村, 富穂

Search repository
出版者
出版者 信州大学
引用
内容記述タイプ Other
内容記述 松村 富穂. Fascin1 supresses RIG-I-like receptor signaling and interferon-β production by associating with IκB kinase ε(IKKε) in colon cancer(RIG-I経路を介したFascin1によるIFN-β抑制制御). 信州大学, 2018, 博士論文.
書誌情報
発行日 2018-03-31
学位授与番号
学位授与番号 13601甲第1133号
学位授与年月日
学位授与年月日 2018-03-31
学位名
学位名 博士(医学)
学位授与機関
学位授与機関名
学位授与機関名 信州大学(Shinshu university)
学位の区分
Doctoral
学位の分野
医学
学位の報告番号
甲第1133号
内容記述
内容記述タイプ Other
内容記述 雑誌に発表。JOURNAL OF BIOLOGICAL CHEMISTRY. 293(17):6326-6336 (2018); doi:10.1074/jbc.M117.819201.
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Thesis
PubMed
関連識別子
識別子タイプ PMID
関連識別子 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search&DB=pubmed&term=29496994
関連名称
関連名称 29496994
DOI
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1074/jbc.M117.819201
関連名称
関連名称 10.1074/jbc.M117.819201
権利
権利情報 This research was originally published in J. Biol. Chem. Tomio Matsumura, Shigeaki Hida, Masato Kitazawa, Chifumi Fujii, Akira Kobayashi, Michiko Takeoka, Shun-ichiro Taniguchi, Shin-ichi Miyagawa. Fascin1 suppresses RIG-I–like receptor signaling and interferon-β production by associating with IκB kinase ϵ (IKKϵ) in colon cancer. J. Biol. Chem. 2018; Vol. 293:6326. © the American Society for Biochemistry and Molecular Biology.
出版タイプ
出版タイプ NA
出版タイプResource http://purl.org/coar/version/c_be7fb7dd8ff6fe43
WoS
Web of Science
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000431108600009
戻る
0
views
See details
Views

Versions

Ver.1 2021-03-01 08:02:43.544983
Show All versions

Share

Mendeley CiteULike Twitter Facebook Print Addthis

Cite as

Export

OAI-PMH
  • OAI-PMH JPCOAR
  • OAI-PMH DublinCore
  • OAI-PMH DDI
Other Formats
  • JSON
  • BIBTEX

Confirm


Powered by CERN Data Centre & Invenio


Powered by CERN Data Centre & Invenio