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By contrast, DPD expression levels were not correlated with overall patient survival. Importantly, patients with low TS and DPD levels exhibited significantly prolonged survival than those with high TS and DPD. Among the 168 patients, 59 patients were treated with tegafur-uracil (UFT), a DPD-inhibitory fluoropyrimidine, and the UFT-treated patients with high TS and high DPD levels showed worst prognosis. Our study demonstrates a significant correlation between low TS expression levels and long-term prognosis of patients with lung cancer. 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  1. 050 医学部, 大学院医学系研究科
  2. 0507 学位論文
  3. 博士(医学)

Higher Tissue Levels of Thymidylate Synthase Determined by ELISA Are Associated with Poor Prognosis of Patients with Lung Cancer(ELISA法を用いて測定した肺癌組織のチミジル酸合成酵素の高発現は肺癌患者の不良な予後と関連する)

http://hdl.handle.net/10091/00020740
0fbb5355-37ed-4821-961f-c9ebdfcfb761
名前 / ファイル ライセンス アクション
17MR0003_yoshi.pdf 内容の要旨 (129.8 kB)
17MR0003_shinsa.pdf 審査結果の要旨 (104.7 kB)
17MR0003_ronbun.pdf 博士論文の全文 (636.5 kB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2018-06-28
タイトル
言語 en
タイトル Higher Tissue Levels of Thymidylate Synthase Determined by ELISA Are Associated with Poor Prognosis of Patients with Lung Cancer(ELISA法を用いて測定した肺癌組織のチミジル酸合成酵素の高発現は肺癌患者の不良な予後と関連する)
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_db06
タイプ doctoral thesis
著者 椎名, 隆之

× 椎名, 隆之

WEKO 105932

椎名, 隆之

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出版者
出版者 信州大学
引用
内容記述タイプ Other
内容記述 椎名 隆之. Higher Tissue Levels of Thymidylate Synthase Determined by ELISA Are Associated with Poor Prognosis of Patients with Lung Cancer(ELISA法を用いて測定した肺癌組織のチミジル酸合成酵素の高発現は肺癌患者の不良な予後と関連する). 信州大学, 2017, 博士論文.
書誌情報
発行日 2017-11-08
学位授与番号
学位授与番号 13601乙第1208号
学位授与年月日
学位授与年月日 2017-11-08
学位名
学位名 博士(医学)
学位授与機関
学位授与機関名
学位授与機関名 信州大学(Shinshu university)
学位の区分
Doctoral
学位の分野
医学
学位の報告番号
乙第1208号
内容記述
内容記述タイプ Other
内容記述 雑誌に発表。TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE. 242(4):303-316 (2017); doi:10.1620/tjem.242.303.
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Thesis
PubMed
関連識別子
識別子タイプ PMID
関連識別子 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search&DB=pubmed&term=28835573
関連名称
関連名称 28835573
DOI
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1620/tjem.242.303
関連名称
関連名称 10.1620/tjem.242.303
権利
権利情報 © 2017 Tohoku University Medical Press
出版タイプ
出版タイプ NA
出版タイプResource http://purl.org/coar/version/c_be7fb7dd8ff6fe43
WoS
Web of Science
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000411045200007
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