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Amyloidosis-inducing Activity of Blood Cells in Mouse AApoAII Amyloidosis\uff08\u30de\u30a6\u30b9\u8840\u7403\u7d30\u80de\u306eAApoAII\u30a2\u30df\u30ed\u30a4\u30c9\u30fc\u30b7\u30b9\u8a98\u767a\u6d3b\u6027\uff09. \u4fe1\u5dde\u5927\u5b66, 2017, \u535a\u58eb\u8ad6\u6587.", "subitem_description_type": "Other"}]}, "item_14_dissertation_number_7": {"attribute_name": "\u5b66\u4f4d\u6388\u4e0e\u756a\u53f7", "attribute_value_mlt": [{"subitem_dissertationnumber": "13601\u4e59\u7b2c1209\u53f7"}]}, "item_14_link_74": {"attribute_name": "WoS", "attribute_value_mlt": [{"subitem_link_text": "Web of Science", "subitem_link_url": "http://gateway.isiknowledge.com/gateway/Gateway.cgi?\u0026GWVersion=2\u0026SrcAuth=ShinshuUniv\u0026SrcApp=ShinshuUniv\u0026DestLinkType=FullRecord\u0026DestApp=WOS\u0026KeyUT=000431472500002"}]}, "item_14_publisher_4": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "\u4fe1\u5dde\u5927\u5b66"}]}, "item_14_relation_54": {"attribute_name": "PubMed", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "29081441"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search\u0026DB=pubmed\u0026term=29081441", "subitem_relation_type_select": "PMID"}}]}, "item_14_relation_55": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "10.1538/expanim.17-0082"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1538/expanim.17-0082", "subitem_relation_type_select": "DOI"}}]}, "item_14_rights_69": {"attribute_name": "\u6a29\u5229", "attribute_value_mlt": [{"subitem_rights": "\u00a9 2018 Japanese Association for Laboratory Animal Science"}]}, "item_14_select_71": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "ETD"}]}, "item_14_text_11": {"attribute_name": "\u5b66\u4f4d\u306e\u533a\u5206", "attribute_value_mlt": [{"subitem_text_value": "Doctoral"}]}, "item_14_text_12": {"attribute_name": "\u5b66\u4f4d\u306e\u5206\u91ce", "attribute_value_mlt": [{"subitem_text_value": "\u533b\u5b66"}]}, "item_14_text_13": {"attribute_name": "\u5b66\u4f4d\u306e\u5831\u544a\u756a\u53f7", "attribute_value_mlt": [{"subitem_text_value": "\u4e59\u7b2c1209\u53f7"}]}, "item_14_text_76": {"attribute_name": "wosonly authkey", "attribute_value_mlt": [{"subitem_text_value": "amyloidosis; apolipoprotein A-II; blood cells; fibrils; transmission"}]}, "item_14_text_77": {"attribute_name": "wosonly keywords", "attribute_value_mlt": [{"subitem_text_value": "APOLIPOPROTEIN-A-II; CREUTZFELDT-JAKOB-DISEASE; SENILE AMYLOIDOSIS; APOA-II; INBRED STRAINS; PRION DISEASES; MICE; TRANSMISSION; FIBRILS; TRANSFUSION"}]}, "item_14_textarea_75": {"attribute_name": "wosonly abstract", "attribute_value_mlt": [{"subitem_textarea_value": "Mouse senile amyloidosis is a disorder in which apolipoprotein A-II (APOA2) deposits as amyloid fibrils (AApoAll) in many organs. We previously reported that AApoAll amyloidosis can be transmitted by feces, milk, saliva and muscle originating from mice with amyloid deposition. In this study, the ability of blood components to transmit amyloidosis was evaluated in our model system. Blood samples were collected from SAMR1.SAMP1-Apoa2(c) amyloid-laden or amyloidosis-negative mice. The samples were fractionated into plasma, white blood cell (WBC) and red blood cell (RBC) fractions. Portions of each were further separated into soluble and insoluble fractions. These fractions were then injected into recipient mice to determine amyloidosis-induction activities (AIA). The WBC and RBC fractions from amyloid-laden mice but not from amyloidosis-negative mice induced AApoAll amyloid deposition in the recipients. The AIA of WBC fraction could be attributed to AApoAll amyloid fibrils because amyloid fibril-like materials and APOA2 antiserum-reactive proteins were observed in the insoluble fraction of the blood cells. Unexpectedly, the plasma of AApoAll amyloidosis-negative as well as amyloid-laden mice showed AIA, suggesting the presence of substances in mouse plasma other than AApoAll fibrils that could induce amyloid deposition. These results indicated that AApoAll amyloidosis could be transmitted across tissues and between individuals through blood cells."}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "\u4e01, \u6b23"}], "nameIdentifiers": [{"nameIdentifier": "105933", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-06-28"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "17MR0006_yoshi.pdf", "filesize": [{"value": "122.0 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 122000.0, "url": {"label": "\u5185\u5bb9\u306e\u8981\u65e8", "url": "https://soar-ir.repo.nii.ac.jp/record/19980/files/17MR0006_yoshi.pdf"}, "version_id": "0f3e97a7-5c54-47c5-8bd4-da6e8894f2ca"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-06-28"}], "displaytype": "detail", "download_preview_message": "", "file_order": 1, "filename": "17MR0006_shinsa.pdf", "filesize": [{"value": "97.8 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 97800.0, "url": {"label": "\u5be9\u67fb\u7d50\u679c\u306e\u8981\u65e8", "url": "https://soar-ir.repo.nii.ac.jp/record/19980/files/17MR0006_shinsa.pdf"}, "version_id": "cf53dcb3-c408-48d8-b03b-324e1d0a6c7d"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-06-28"}], "displaytype": "detail", "download_preview_message": "", "file_order": 2, "filename": "17MR0006_ronbun.pdf", "filesize": [{"value": "1.3 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensefree": "\u00a9 2018 Japanese Association for Laboratory Animal Science", "licensetype": "license_free", "mimetype": "application/pdf", "size": 1300000.0, "url": {"label": "\u535a\u58eb\u8ad6\u6587\u306e\u5168\u6587", "url": "https://soar-ir.repo.nii.ac.jp/record/19980/files/17MR0006_ronbun.pdf"}, "version_id": "6fcecaef-33d8-41af-9072-ad26b39a6034"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "thesis", "resourceuri": "http://purl.org/coar/resource_type/c_46ec"}]}, "item_title": "Amyloidosis-inducing Activity of Blood Cells in Mouse AApoAII Amyloidosis\uff08\u30de\u30a6\u30b9\u8840\u7403\u7d30\u80de\u306eAApoAII\u30a2\u30df\u30ed\u30a4\u30c9\u30fc\u30b7\u30b9\u8a98\u767a\u6d3b\u6027\uff09", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Amyloidosis-inducing Activity of Blood Cells in Mouse AApoAII Amyloidosis\uff08\u30de\u30a6\u30b9\u8840\u7403\u7d30\u80de\u306eAApoAII\u30a2\u30df\u30ed\u30a4\u30c9\u30fc\u30b7\u30b9\u8a98\u767a\u6d3b\u6027\uff09"}]}, "item_type_id": "14", "owner": "1", "path": ["461/848/849"], "permalink_uri": "http://hdl.handle.net/10091/00020741", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_name_i18n": "\u516c\u958b\u65e5", "attribute_value": "2018-06-28"}, "publish_date": "2018-06-28", "publish_status": "0", "recid": "19980", "relation": {}, "relation_version_is_last": true, "title": ["Amyloidosis-inducing Activity of Blood Cells in Mouse AApoAII Amyloidosis\uff08\u30de\u30a6\u30b9\u8840\u7403\u7d30\u80de\u306eAApoAII\u30a2\u30df\u30ed\u30a4\u30c9\u30fc\u30b7\u30b9\u8a98\u767a\u6d3b\u6027\uff09"], "weko_shared_id": null}