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We previously reported that AApoAll amyloidosis can be transmitted by feces, milk, saliva and muscle originating from mice with amyloid deposition. In this study, the ability of blood components to transmit amyloidosis was evaluated in our model system. Blood samples were collected from SAMR1.SAMP1-Apoa2(c) amyloid-laden or amyloidosis-negative mice. The samples were fractionated into plasma, white blood cell (WBC) and red blood cell (RBC) fractions. Portions of each were further separated into soluble and insoluble fractions. These fractions were then injected into recipient mice to determine amyloidosis-induction activities (AIA). The WBC and RBC fractions from amyloid-laden mice but not from amyloidosis-negative mice induced AApoAll amyloid deposition in the recipients. The AIA of WBC fraction could be attributed to AApoAll amyloid fibrils because amyloid fibril-like materials and APOA2 antiserum-reactive proteins were observed in the insoluble fraction of the blood cells. Unexpectedly, the plasma of AApoAll amyloidosis-negative as well as amyloid-laden mice showed AIA, suggesting the presence of substances in mouse plasma other than AApoAll fibrils that could induce amyloid deposition. 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  1. 050 医学部, 大学院医学系研究科
  2. 0507 学位論文
  3. 博士(医学)

Amyloidosis-inducing Activity of Blood Cells in Mouse AApoAII Amyloidosis(マウス血球細胞のAApoAIIアミロイドーシス誘発活性)

http://hdl.handle.net/10091/00020741
http://hdl.handle.net/10091/00020741
fad45590-c805-404b-9b11-981e0282f41e
名前 / ファイル ライセンス アクション
17MR0006_yoshi.pdf 内容の要旨 (122.0 kB)
17MR0006_shinsa.pdf 審査結果の要旨 (97.8 kB)
17MR0006_ronbun.pdf 博士論文の全文 (1.3 MB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2018-06-28
タイトル
言語 en
タイトル Amyloidosis-inducing Activity of Blood Cells in Mouse AApoAII Amyloidosis(マウス血球細胞のAApoAIIアミロイドーシス誘発活性)
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_db06
タイプ doctoral thesis
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
著者 丁, 欣

× 丁, 欣

WEKO 105933

ja 丁, 欣

Search repository
出版者
出版者 信州大学
引用
内容記述タイプ Other
内容記述 丁 欣. Amyloidosis-inducing Activity of Blood Cells in Mouse AApoAII Amyloidosis(マウス血球細胞のAApoAIIアミロイドーシス誘発活性). 信州大学, 2017, 博士論文.
書誌情報
発行日 2017-11-22
学位授与番号
学位授与番号 13601乙第1209号
学位授与年月日
学位授与年月日 2017-11-22
学位名
学位名 博士(医学)
学位授与機関
学位授与機関識別子Scheme kakenhi
学位授与機関識別子 13601
学位授与機関名 信州大学(Shinshu university)
学位の区分
doctoral
学位の分野
医学
学位の報告番号
乙第1209号
内容記述
内容記述タイプ Other
内容記述 雑誌に発表。EXPERIMENTAL ANIMALS. 67(2):105-115 (2018); doi:10.1538/expanim.17-0082.
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Thesis
PubMed
識別子タイプ PMID
関連識別子 https://pubmed.ncbi.nlm.nih.gov/29081441/
関連名称 29081441
DOI
識別子タイプ DOI
関連識別子 https://doi.org/10.1538/expanim.17-0082
関連名称 10.1538/expanim.17-0082
権利
権利情報 © 2018 Japanese Association for Laboratory Animal Science
出版タイプ
出版タイプ NA
出版タイプResource http://purl.org/coar/version/c_be7fb7dd8ff6fe43
WoS
Web of Science
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000431472500002
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