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We previously reported that AApoAll amyloidosis can be transmitted by feces, milk, saliva and muscle originating from mice with amyloid deposition. In this study, the ability of blood components to transmit amyloidosis was evaluated in our model system. Blood samples were collected from SAMR1.SAMP1-Apoa2(c) amyloid-laden or amyloidosis-negative mice. The samples were fractionated into plasma, white blood cell (WBC) and red blood cell (RBC) fractions. Portions of each were further separated into soluble and insoluble fractions. These fractions were then injected into recipient mice to determine amyloidosis-induction activities (AIA). The WBC and RBC fractions from amyloid-laden mice but not from amyloidosis-negative mice induced AApoAll amyloid deposition in the recipients. The AIA of WBC fraction could be attributed to AApoAll amyloid fibrils because amyloid fibril-like materials and APOA2 antiserum-reactive proteins were observed in the insoluble fraction of the blood cells. Unexpectedly, the plasma of AApoAll amyloidosis-negative as well as amyloid-laden mice showed AIA, suggesting the presence of substances in mouse plasma other than AApoAll fibrils that could induce amyloid deposition. These results indicated that AApoAll amyloidosis could be transmitted across tissues and between individuals through blood cells."}]}, "item_1627890986942": {"attribute_name": "\u51fa\u7248\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_be7fb7dd8ff6fe43", "subitem_version_type": "NA"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "\u4e01, \u6b23"}], "nameIdentifiers": [{"nameIdentifier": "105933", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-06-28"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "17MR0006_yoshi.pdf", "filesize": [{"value": "122.0 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 122000.0, "url": {"label": "\u5185\u5bb9\u306e\u8981\u65e8", "url": "https://soar-ir.repo.nii.ac.jp/record/19980/files/17MR0006_yoshi.pdf"}, "version_id": "0f3e97a7-5c54-47c5-8bd4-da6e8894f2ca"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-06-28"}], "displaytype": "detail", "download_preview_message": "", "file_order": 1, "filename": "17MR0006_shinsa.pdf", "filesize": [{"value": "97.8 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 97800.0, "url": {"label": "\u5be9\u67fb\u7d50\u679c\u306e\u8981\u65e8", "url": "https://soar-ir.repo.nii.ac.jp/record/19980/files/17MR0006_shinsa.pdf"}, "version_id": "cf53dcb3-c408-48d8-b03b-324e1d0a6c7d"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-06-28"}], "displaytype": "detail", "download_preview_message": "", "file_order": 2, "filename": "17MR0006_ronbun.pdf", "filesize": [{"value": "1.3 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensefree": "\u00a9 2018 Japanese Association for Laboratory Animal Science", "licensetype": "license_note", "mimetype": "application/pdf", "size": 1300000.0, "url": {"label": "\u535a\u58eb\u8ad6\u6587\u306e\u5168\u6587", "url": "https://soar-ir.repo.nii.ac.jp/record/19980/files/17MR0006_ronbun.pdf"}, "version_id": "6fcecaef-33d8-41af-9072-ad26b39a6034"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "doctoral thesis", "resourceuri": "http://purl.org/coar/resource_type/c_db06"}]}, "item_title": "Amyloidosis-inducing Activity of Blood Cells in Mouse AApoAII Amyloidosis\uff08\u30de\u30a6\u30b9\u8840\u7403\u7d30\u80de\u306eAApoAII\u30a2\u30df\u30ed\u30a4\u30c9\u30fc\u30b7\u30b9\u8a98\u767a\u6d3b\u6027\uff09", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Amyloidosis-inducing Activity of Blood Cells in Mouse AApoAII Amyloidosis\uff08\u30de\u30a6\u30b9\u8840\u7403\u7d30\u80de\u306eAApoAII\u30a2\u30df\u30ed\u30a4\u30c9\u30fc\u30b7\u30b9\u8a98\u767a\u6d3b\u6027\uff09", "subitem_title_language": "en"}]}, "item_type_id": "14", "owner": "1", "path": ["461/848/849"], "permalink_uri": "http://hdl.handle.net/10091/00020741", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2018-06-28"}, "publish_date": "2018-06-28", "publish_status": "0", "recid": "19980", "relation": {}, "relation_version_is_last": true, "title": ["Amyloidosis-inducing Activity of Blood Cells in Mouse AApoAII Amyloidosis\uff08\u30de\u30a6\u30b9\u8840\u7403\u7d30\u80de\u306eAApoAII\u30a2\u30df\u30ed\u30a4\u30c9\u30fc\u30b7\u30b9\u8a98\u767a\u6d3b\u6027\uff09"], "weko_shared_id": -1}
Amyloidosis-inducing Activity of Blood Cells in Mouse AApoAII Amyloidosis(マウス血球細胞のAApoAIIアミロイドーシス誘発活性)
http://hdl.handle.net/10091/00020741
fad45590-c805-404b-9b11-981e0282f41e
名前 / ファイル | ライセンス | アクション | |
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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公開日 | 2018-06-28 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Amyloidosis-inducing Activity of Blood Cells in Mouse AApoAII Amyloidosis(マウス血球細胞のAApoAIIアミロイドーシス誘発活性) | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_db06 | |||||
タイプ | doctoral thesis | |||||
著者 |
丁, 欣
× 丁, 欣 |
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出版者 | ||||||
出版者 | 信州大学 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 丁 欣. Amyloidosis-inducing Activity of Blood Cells in Mouse AApoAII Amyloidosis(マウス血球細胞のAApoAIIアミロイドーシス誘発活性). 信州大学, 2017, 博士論文. | |||||
書誌情報 |
発行日 2017-11-22 |
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学位授与番号 | ||||||
学位授与番号 | 13601乙第1209号 | |||||
学位授与年月日 | ||||||
学位授与年月日 | 2017-11-22 | |||||
学位名 | ||||||
学位名 | 博士(医学) | |||||
学位授与機関 | ||||||
学位授与機関名 | ||||||
学位授与機関名 | 信州大学(Shinshu university) | |||||
学位の区分 | ||||||
Doctoral | ||||||
学位の分野 | ||||||
医学 | ||||||
学位の報告番号 | ||||||
乙第1209号 | ||||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 雑誌に発表。EXPERIMENTAL ANIMALS. 67(2):105-115 (2018); doi:10.1538/expanim.17-0082. | |||||
資源タイプ(コンテンツの種類) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Thesis | |||||
PubMed | ||||||
関連識別子 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search&DB=pubmed&term=29081441 | |||||
関連名称 | ||||||
関連名称 | 29081441 | |||||
DOI | ||||||
関連識別子 | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1538/expanim.17-0082 | |||||
関連名称 | ||||||
関連名称 | 10.1538/expanim.17-0082 | |||||
権利 | ||||||
権利情報 | © 2018 Japanese Association for Laboratory Animal Science | |||||
出版タイプ | ||||||
出版タイプ | NA | |||||
出版タイプResource | http://purl.org/coar/version/c_be7fb7dd8ff6fe43 | |||||
WoS | ||||||
Web of Science | ||||||
URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000431472500002 |