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Methods: Twenty-one frozen tissue samples of iodine-stained and unstained mucosal tissue were obtained from 21 OSCC patients. Serial frozen sections were cut and examined with the hematoxylin-eosin and periodic acid Schiff methods and immunohistochemical (IHC) staining for Ki67, P53, molecules associated with glycogenesis (i.e., glycogen synthase (GS) and phospho-glycogen synthase (PGS)), and molecules associated with glycogenolysis (i.e., glycogen phosphorylase isoenzyme BB (GPBB) examine the glycogen metabolism in OSCC. Additionally, in vitro study, the expression levels of GS and GPBB in the cultured cells were analyzed by immunofluorescent staining, Western blot analysis, and the real-time quantitative polymerase chain reaction (PCR). Results: There was no significant difference in GS and PGS immunoactivity between iodine stained and unstained area. On the other hand, significantly greater GPBB immunoreactivity was observed in the basal and parabasal layers of iodine-unstained epithelium, where higher positivity for p53 and Ki67 was also showed. Additionally, western blot analysis, immunofluorescent staining, and real-time quantitative PCR revealed that the oral squamous cancer cells exhibited greater expression of GPBB than normal epithelial cells. Conclusions: The results of this study showed that GPBB expression, which resulted in up-regulation of glycogenolysis, is enhanced in oral dysplastic/malignant epithelium compared with non-keartinized normal epithelium, in spite of the fact that glycogenesis continues in both of them. Premalignant and malignant epithelial cells consume greater quantities of energy due to their increased proliferation, and hence, exhaust their glycogen stores, which resulting in negative stain reaction with iodine solution."}]}, "item_1627890986942": {"attribute_name": "\u51fa\u7248\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_be7fb7dd8ff6fe43", "subitem_version_type": "NA"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "\u76f8\u6fa4, \u4ec1\u5fd7"}], "nameIdentifiers": [{"nameIdentifier": "105934", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-06-28"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "17MR0005_yoshi.pdf", "filesize": [{"value": "126.6 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 126600.0, "url": {"label": "\u5185\u5bb9\u306e\u8981\u65e8", "url": "https://soar-ir.repo.nii.ac.jp/record/19981/files/17MR0005_yoshi.pdf"}, "version_id": "cac5df32-27de-4e21-9d65-d1c13eed0d16"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-06-28"}], "displaytype": "detail", "download_preview_message": "", "file_order": 1, "filename": "17MR0005_shinsa.pdf", "filesize": [{"value": "106.5 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 106500.0, "url": {"label": "\u5be9\u67fb\u7d50\u679c\u306e\u8981\u65e8", "url": "https://soar-ir.repo.nii.ac.jp/record/19981/files/17MR0005_shinsa.pdf"}, "version_id": "4f31bb91-990d-4810-910e-8be4fbef8ad9"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-11-01"}], "displaytype": "detail", "download_preview_message": "", "file_order": 2, "filename": "17MR0005_ronbun.pdf", "filesize": [{"value": "1.3 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensefree": "\u00a9 2017. 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  1. 050 医学部, 大学院医学系研究科
  2. 0507 学位論文
  3. 博士(医学)

Difference in glycogen metabolism (glycogen synthesis and glycolysis) between normal and dysplastic/malignant oral epithelium(口腔正常粘膜上皮と異型/悪性粘膜上皮におけるグリコーゲン代謝(グリコーゲン合成と分解)の相違)

http://hdl.handle.net/10091/00020742
6e7cc479-8a11-4e02-8e7d-8837ffc78193
名前 / ファイル ライセンス アクション
17MR0005_yoshi.pdf 内容の要旨 (126.6 kB)
17MR0005_shinsa.pdf 審査結果の要旨 (106.5 kB)
17MR0005_ronbun.pdf 博士論文の全文 (1.3 MB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2018-06-28
タイトル
言語 en
タイトル Difference in glycogen metabolism (glycogen synthesis and glycolysis) between normal and dysplastic/malignant oral epithelium(口腔正常粘膜上皮と異型/悪性粘膜上皮におけるグリコーゲン代謝(グリコーゲン合成と分解)の相違)
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_db06
タイプ doctoral thesis
著者 相澤, 仁志

× 相澤, 仁志

WEKO 105934

相澤, 仁志

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出版者
出版者 信州大学
引用
内容記述タイプ Other
内容記述 相澤 仁志. Difference in glycogen metabolism (glycogen synthesis and glycolysis) between normal and dysplastic/malignant oral epithelium(口腔正常粘膜上皮と異型/悪性粘膜上皮におけるグリコーゲン代謝(グリコーゲン合成と分解)の相違). 信州大学, 2017, 博士論文.
書誌情報
発行日 2017-12-27
学位授与番号
学位授与番号 13601乙第1210号
学位授与年月日
学位授与年月日 2017-12-27
学位名
学位名 博士(医学)
学位授与機関
学位授与機関名
学位授与機関名 信州大学(Shinshu university)
学位の区分
Doctoral
学位の分野
医学
学位の報告番号
乙第1210号
内容記述
内容記述タイプ Other
内容記述 雑誌に発表。ARCHIVES OF ORAL BIOLOGY. 83:340-347 (2017); doi:10.1016/j.archoralbio.2017.08.014.
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Thesis
PubMed
関連識別子
識別子タイプ PMID
関連識別子 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search&DB=pubmed&term=28892665
関連名称
関連名称 28892665
DOI
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1016/j.archoralbio.2017.08.014
関連名称
関連名称 10.1016/j.archoralbio.2017.08.014
権利
権利情報 © 2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
出版タイプ
出版タイプ NA
出版タイプResource http://purl.org/coar/version/c_be7fb7dd8ff6fe43
WoS
Web of Science
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000413280900049
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