| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2021-05-26 |
| タイトル |
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タイトル |
Myogenetic oligodeoxynucleotide (myoDN) recovers the differentiation of skeletal muscle myoblasts deteriorated by diabetes mellitus. |
| タイトル |
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タイトル |
Myogenetic oligodeoxynucleotide (myoDN) recovers the differentiation of skeletal muscle myoblasts deteriorated by diabetes mellitus. |
| 言語 |
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言語 |
eng |
| DOI |
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関連タイプ |
isIdenticalTo |
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関連識別子 |
10.3389/fphys.2021.679152 |
| キーワード |
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主題 |
myogenetic oligodeoxynucleotide, skeletal muscle, myoblast, myogenic differentiation, diabetes mellitus |
| 資源タイプ |
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資源 |
http://purl.org/coar/resource_type/c_6501 |
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タイプ |
journal article |
| 著者 |
Nakamura, Shunichi
Yonekura, Shinichi
Shimosato, Takeshi
Takaya, Tomohide
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| 信州大学研究者総覧へのリンク |
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氏名 |
米倉, 真一 |
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URL |
https://soar-rd.shinshu-u.ac.jp/profile/ja.gakFPUkh.html |
| 信州大学研究者総覧へのリンク |
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氏名 |
下里, 剛士 |
|
URL |
https://soar-rd.shinshu-u.ac.jp/profile/ja.ONLCjFkV.html |
| 信州大学研究者総覧へのリンク |
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氏名 |
高谷, 智英 |
|
URL |
https://soar-rd.shinshu-u.ac.jp/profile/ja.yUcePUkh.html |
| 出版者 |
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出版者 |
Frontiers |
| 引用 |
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内容記述 |
Frontiers in Physiology. 12 : 679152 (2021) |
| 書誌情報 |
Frontiers in Physiology
巻 12,
p. 679152-679152,
発行日 2021-05-24
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| 抄録 |
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内容記述 |
Skeletal muscle wasting in patients with diabetes mellitus (DM) is a complication of decreased muscle mass and strength, and is a serious risk factor that may result in mortality. Deteriorated differentiation of muscle precursor cells, called myoblasts, in DM patients is considered to be one of the causes of muscle wasting.We recently developed myogenetic oligodeoxynucleotides (myoDNs), which are 18-base single-strand DNAs that promote myoblast differentiation by targeting nucleolin. Herein, we report the applicability of a myoDN, iSN04, to myoblasts isolated from patients with type 1 and type 2 DM. Myogenesis of DM myoblasts was exacerbated concordantly with a delayed shift of myogenic transcription and induction of interleukins. Analogous phenotypes were reproduced in healthy myoblasts cultured with excessive glucose or palmitic acid, mimicking hyperglycemia or hyperlipidemia. iSN04 treatment recovered the deteriorated differentiation of plural DM myoblasts by downregulating myostatin and interleukin-8 (IL-8). iSN04 also ameliorated the impaired myogenic differentiation induced by glucose or palmitic acid. These results demonstrate that myoDNs can directly facilitate myoblast differentiation in DM patients, making them novel candidates for nucleic acid drugs to treat muscle wasting in patients with DM. |
| 資源タイプ（コンテンツの種類） |
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| ISSN |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
1664-042X |
| 権利 |
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権利情報 |
© Authers 2021 |
| 出版タイプ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
FrontPhysiol_12-679152.pdf (2.2 MB)
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