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  1. 070 農学部, 大学院農学研究科
  2. 0701 学術論文

Myogenetic oligodeoxynucleotide (myoDN) recovers the differentiation of skeletal muscle myoblasts deteriorated by diabetes mellitus.

http://hdl.handle.net/10091/0002000158
http://hdl.handle.net/10091/0002000158
671d073a-bfbb-42a6-b2bd-1f0440f7823d
名前 / ファイル ライセンス アクション
FrontPhysiol_12-679152.pdf FrontPhysiol_12-679152.pdf (2.2 MB)
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Item type 学術雑誌論文 / Journal Article(1)
公開日 2021-05-26
タイトル
タイトル Myogenetic oligodeoxynucleotide (myoDN) recovers the differentiation of skeletal muscle myoblasts deteriorated by diabetes mellitus.
タイトル
タイトル Myogenetic oligodeoxynucleotide (myoDN) recovers the differentiation of skeletal muscle myoblasts deteriorated by diabetes mellitus.
言語
言語 eng
DOI
関連タイプ isIdenticalTo
関連識別子 10.3389/fphys.2021.679152
キーワード
主題 myogenetic oligodeoxynucleotide, skeletal muscle, myoblast, myogenic differentiation, diabetes mellitus
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Nakamura, Shunichi

× Nakamura, Shunichi

ja Nakamura, Shunichi

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Yonekura, Shinichi

× Yonekura, Shinichi

ja Yonekura, Shinichi

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Shimosato, Takeshi

× Shimosato, Takeshi

ja Shimosato, Takeshi

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Takaya, Tomohide

× Takaya, Tomohide

ja Takaya, Tomohide

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信州大学研究者総覧へのリンク
氏名 米倉, 真一
URL https://soar-rd.shinshu-u.ac.jp/profile/ja.gakFPUkh.html
信州大学研究者総覧へのリンク
氏名 下里, 剛士
URL https://soar-rd.shinshu-u.ac.jp/profile/ja.ONLCjFkV.html
信州大学研究者総覧へのリンク
氏名 高谷, 智英
URL https://soar-rd.shinshu-u.ac.jp/profile/ja.yUcePUkh.html
出版者
出版者 Frontiers
引用
内容記述 Frontiers in Physiology. 12 : 679152 (2021)
書誌情報 Frontiers in Physiology

巻 12, p. 679152-679152, 発行日 2021-05-24
抄録
内容記述 Skeletal muscle wasting in patients with diabetes mellitus (DM) is a complication of decreased muscle mass and strength, and is a serious risk factor that may result in mortality. Deteriorated differentiation of muscle precursor cells, called myoblasts, in DM patients is considered to be one of the causes of muscle wasting.We recently developed myogenetic oligodeoxynucleotides (myoDNs), which are 18-base single-strand DNAs that promote myoblast differentiation by targeting nucleolin. Herein, we report the applicability of a myoDN, iSN04, to myoblasts isolated from patients with type 1 and type 2 DM. Myogenesis of DM myoblasts was exacerbated concordantly with a delayed shift of myogenic transcription and induction of interleukins. Analogous phenotypes were reproduced in healthy myoblasts cultured with excessive glucose or palmitic acid, mimicking hyperglycemia or hyperlipidemia. iSN04 treatment recovered the deteriorated differentiation of plural DM myoblasts by downregulating myostatin and interleukin-8 (IL-8). iSN04 also ameliorated the impaired myogenic differentiation induced by glucose or palmitic acid. These results demonstrate that myoDNs can directly facilitate myoblast differentiation in DM patients, making them novel candidates for nucleic acid drugs to treat muscle wasting in patients with DM.
資源タイプ(コンテンツの種類)
ISSN
収録物識別子タイプ EISSN
収録物識別子 1664-042X
権利
権利情報 © Authers 2021
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
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Cite as

Nakamura, Shunichi, Yonekura, Shinichi, Shimosato, Takeshi, Takaya, Tomohide, 2021, Myogenetic oligodeoxynucleotide (myoDN) recovers the differentiation of skeletal muscle myoblasts deteriorated by diabetes mellitus.: Frontiers, 679152–679152 p.

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