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Theobromine enhances the conversion of white adipocytes into beige adipocytes in a PPARγ activation-dependent manner
http://hdl.handle.net/10091/0002000690
http://hdl.handle.net/10091/00020006907fd4fd9a-5935-4cce-b426-8fc4a7cf76dd
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
Jnutritbiochem100_108933.pdf
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||||||
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| 公開日 | 2022-01-20 | |||||||||||||||||
| タイトル | ||||||||||||||||||
| タイトル | Theobromine enhances the conversion of white adipocytes into beige adipocytes in a PPARγ activation-dependent manner | |||||||||||||||||
| 言語 | ||||||||||||||||||
| 言語 | eng | |||||||||||||||||
| DOI | ||||||||||||||||||
| 関連タイプ | isVersionOf | |||||||||||||||||
| 関連識別子 | https://doi.org/10.1016/j.jnutbio.2021.108898 | |||||||||||||||||
| 関連名称 | 10.1016/j.jnutbio.2021.108898 | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 主題 | Autophagy, Browning, Beige adipocyte, Theobromine, Peroxisome proliferator-activated receptor γ | |||||||||||||||||
| 資源タイプ | ||||||||||||||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||
| タイプ | journal article | |||||||||||||||||
| 著者 |
Tanaka, Emi
× Tanaka, Emi
× Mitani, Takakazu
× Nakashima, Momona
× Yonemoto, Eito
× Fujii, Hiroshi
× Ashida, Hitoshi
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| 信州大学研究者総覧へのリンク | ||||||||||||||||||
| 氏名 | 三谷, 塁一 | |||||||||||||||||
| URL | https://soar-rd.shinshu-u.ac.jp/profile/ja.ypcCPUkh.html | |||||||||||||||||
| 信州大学研究者総覧へのリンク | ||||||||||||||||||
| 氏名 | 藤井, 博 | |||||||||||||||||
| URL | https://soar-rd.shinshu-u.ac.jp/profile/ja.WhymjeSh.html | |||||||||||||||||
| 出版者 | ||||||||||||||||||
| 出版者 | Elsevier | |||||||||||||||||
| 引用 | ||||||||||||||||||
| 内容記述 | The Journal of Nutritional Biochemistry. 100: 108898 (2021) | |||||||||||||||||
| 書誌情報 |
The Journal of Nutritional Biochemistry 巻 100, p. 108933, 発行日 2021-11-05 |
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| 抄録 | ||||||||||||||||||
| 内容記述 | The adipocytes play an important role in driving the obese-state—white adipose tissue (WAT) stores the excess energy as fat, wherein brown adipose tissue (BAT) is responsible for energy expenditure via the thermoregulatory function of uncoupling protein 1 (UCP1)—the imbalance between these two onsets obesity. Moreover, the anti-obesity effects of brown-like-adipocytes (beige) in WAT are well documented. Browning, the process of transformation of energy-storing into energy-dissipating adipocytes, is a potential preventive strategy against obesity and its related diseases. In the present study, to explore an alternative source of natural products in the regulation of adipocyte transformation, we assessed the potential of theobromine (TB), a bitter alkaloid of the cacao plant, inducing browning in mice (in vivo) and primary adipocytes (in vitro). Dietary supplementation of TB significantly increased skin temperature of the inguinal region in mice and induced the expression of UCP1 protein. It also increased the expression levels of mitochondrial marker proteins in subcutaneous adipose tissues but not in visceral adipose tissues. The microarray analysis showed that TB supplementation upregulated multiple thermogenic and beige adipocyte marker genes in subcutaneous adipose tissue. Furthermore, in mouse-derived primary adipocytes, TB upregulated the expression of the UCP1 protein and mitochondrial mass in a PPARγ ligand-dependent manner. It also increased the phosphorylation levels of PPARγ coactivator 1α without affecting its protein expression. These results indicate that dietary supplementation of TB induces browning in subcutaneous WAT and enhances PPARγ-induced UCP1 expression in vitro, suggesting its potential to treat obesity. | |||||||||||||||||
| 資源タイプ（コンテンツの種類） | ||||||||||||||||||
| ISSN | ||||||||||||||||||
| 収録物識別子タイプ | EISSN | |||||||||||||||||
| 収録物識別子 | 0955-2863 | |||||||||||||||||
| 書誌レコードID | ||||||||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||||||||
| 収録物識別子 | AA11533735 | |||||||||||||||||
| PubMed | ||||||||||||||||||
| 識別子タイプ | PMID | |||||||||||||||||
| 関連識別子 | https://pubmed.ncbi.nlm.nih.gov/34748921/ | |||||||||||||||||
| 関連名称 | 34748921 | |||||||||||||||||
| 出版タイプ | ||||||||||||||||||
| 出版タイプ | AM | |||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||||||||||
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Tanaka, Emi, Mitani, Takakazu, Nakashima, Momona, Yonemoto, Eito, Fujii, Hiroshi, Ashida, Hitoshi, 2021, Theobromine enhances the conversion of white adipocytes into beige adipocytes in a PPARγ activation-dependent manner: Elsevier, 108933– p.
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