{"_buckets": {"deposit": "eaf0690a-5455-4c92-bdc9-007e101f0a2b"}, "_deposit": {"id": "2000690", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "2000690"}, "status": "published"}, "_oai": {"id": "oai:soar-ir.repo.nii.ac.jp:02000690", "sets": ["1016:1017"]}, "author_link": [], "control_number": "2000690", "item_1628147817048": {"attribute_name": "\u51fa\u7248\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_ab4af688f83e57aa", "subitem_version_type": "AM"}]}, "item_6_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2021-11-05", "bibliographicIssueDateType": "Issued"}, "bibliographicPageStart": "108933", "bibliographicVolumeNumber": "100", "bibliographic_titles": [{"bibliographic_title": "The Journal of Nutritional Biochemistry"}]}]}, "item_6_description_20": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "The adipocytes play an important role in driving the obese-state\u2014white adipose tissue (WAT) stores the excess energy as fat, wherein brown adipose tissue (BAT) is responsible for energy expenditure via the thermoregulatory function of uncoupling protein 1 (UCP1)\u2014the imbalance between these two onsets obesity. Moreover, the anti-obesity effects of brown-like-adipocytes (beige) in WAT are well documented. Browning, the process of transformation of energy-storing into energy-dissipating adipocytes, is a potential preventive strategy against obesity and its related diseases. In the present study, to explore an alternative source of natural products in the regulation of adipocyte transformation, we assessed the potential of theobromine (TB), a bitter alkaloid of the cacao plant, inducing browning in mice (in vivo) and primary adipocytes (in vitro). Dietary supplementation of TB significantly increased skin temperature of the inguinal region in mice and induced the expression of UCP1 protein. It also increased the expression levels of mitochondrial marker proteins in subcutaneous adipose tissues but not in visceral adipose tissues. The microarray analysis showed that TB supplementation upregulated multiple thermogenic and beige adipocyte marker genes in subcutaneous adipose tissue. Furthermore, in mouse-derived primary adipocytes, TB upregulated the expression of the UCP1 protein and mitochondrial mass in a PPAR\u03b3 ligand-dependent manner. It also increased the phosphorylation levels of PPAR\u03b3 coactivator 1\u03b1 without affecting its protein expression. These results indicate that dietary supplementation of TB induces browning in subcutaneous WAT and enhances PPAR\u03b3-induced UCP1 expression in vitro, suggesting its potential to treat obesity.", "subitem_description_type": "Abstract"}]}, "item_6_description_30": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7\uff08\u30b3\u30f3\u30c6\u30f3\u30c4\u306e\u7a2e\u985e\uff09", "attribute_value_mlt": [{"subitem_description": "Article", "subitem_description_type": "Other"}]}, "item_6_description_5": {"attribute_name": "\u5f15\u7528", "attribute_value_mlt": [{"subitem_description": "The Journal of Nutritional Biochemistry. 100: 108898 (2021)", "subitem_description_type": "Other"}]}, "item_6_link_3": {"attribute_name": "\u4fe1\u5dde\u5927\u5b66\u7814\u7a76\u8005\u7dcf\u89a7\u3078\u306e\u30ea\u30f3\u30af", "attribute_value_mlt": [{"subitem_link_text": "\u4e09\u8c37, \u5841\u4e00", "subitem_link_url": "https://soar-rd.shinshu-u.ac.jp/profile/ja.ypcCPUkh.html"}, {"subitem_link_text": "\u85e4\u4e95, \u535a", "subitem_link_url": "https://soar-rd.shinshu-u.ac.jp/profile/ja.WhymjeSh.html"}]}, "item_6_publisher_4": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "Elsevier"}]}, "item_6_relation_47": {"attribute_name": "PubMed", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "34748921"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://pubmed.ncbi.nlm.nih.gov/34748921/", "subitem_relation_type_select": "PMID"}}]}, "item_6_relation_48": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "10.1016/j.jnutbio.2021.108898"}], "subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1016/j.jnutbio.2021.108898", "subitem_relation_type_select": "DOI"}}]}, "item_6_select_64": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": 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{"creatorNames": [{"creatorName": "Fujii, Hiroshi", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Ashida, Hitoshi", "creatorNameLang": "en"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2022-11-06"}], "download_preview_message": "Download / Preview is available from 2022/11/5.", "file_order": 0, "filename": "Jnutritbiochem100_108933.pdf", "format": "application/pdf", "future_date_message": "Download is available from 2022/11/5.", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 0, "url": {"label": "Jnutritbiochem100_108933.pdf", "url": "https://soar-ir.repo.nii.ac.jp/record/2000690/files/Jnutritbiochem100_108933.pdf"}, "version_id": "94239665-855e-468e-b0d3-96299a9e57d7"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "Autophagy", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Browning", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Beige adipocyte", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Theobromine", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Peroxisome proliferator-activated receptor \u03b3", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Theobromine enhances the conversion of white adipocytes into beige adipocytes in a PPAR\u03b3 activation-dependent manner", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Theobromine enhances the conversion of white adipocytes into beige adipocytes in a PPAR\u03b3 activation-dependent manner", "subitem_title_language": "en"}]}, "item_type_id": "6", "owner": "1", "path": ["1016/1017"], "permalink_uri": "http://hdl.handle.net/10091/0002000690", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2022-01-20"}, "publish_date": "2022-01-20", "publish_status": "0", "recid": "2000690", "relation": {}, "relation_version_is_last": true, "title": ["Theobromine enhances the conversion of white adipocytes into beige adipocytes in a PPAR\u03b3 activation-dependent manner"], "weko_shared_id": -1}