{"_buckets": {"deposit": "55a6504b-f962-4b38-a3ad-55a44eaebff8"}, "_deposit": {"id": "2000706", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "2000706"}, "status": "published"}, "_oai": {"id": "oai:soar-ir.repo.nii.ac.jp:02000706", "sets": ["1222"]}, "author_link": [], "control_number": "2000706", "item_1628147817048": {"attribute_name": "出版タイプ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_ab4af688f83e57aa", "subitem_version_type": "AM"}]}, "item_6_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2022-02", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "2", "bibliographicPageEnd": "272", "bibliographicPageStart": "260", "bibliographicVolumeNumber": "86", "bibliographic_titles": [{"bibliographic_title": "Bioscience, biotechnology, and biochemistry."}]}]}, "item_6_description_20": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Genistein exerts antiadipogenic effects, but its target molecules remain unclear. Here, we delineated the molecular mechanism underlying the antiadipogenic effect of genistein. A pulldown assay using genistein-immobilized beads identified adenine nucleotide translocase-2 as a genistein-binding protein in adipocytes. Adenine nucleotide translocase-2 exchanges ADP/ATP through the mitochondrial inner membrane. Similar to the knockdown of adenine nucleotide translocase-2, genistein treatment decreased ADP uptake into the mitochondria and ATP synthesis. Genistein treatment and adenine nucleotide translocase-2 knockdown suppressed adipogenesis and increased phosphorylation of AMP-activated protein kinase. Adenine nucleotide translocase-2 knockdown reduced the transcriptional activity of CCAAT/enhancer-binding protein β, whereas AMP-activated protein kinase inhibition restored the suppression of adipogenesis by adenine nucleotide translocase-2 knockdown. These results indicate that genistein interacts directly with adenine nucleotide translocase-2 to suppress its function. The downregulation of adenine nucleotide translocase-2 reduces the transcriptional activity of CCAAT/enhancer-binding protein β via activation of AMP-activated protein kinase, which consequently represses adipogenesis.", "subitem_description_type": "Abstract"}]}, "item_6_description_30": {"attribute_name": "資源タイプ(コンテンツの種類)", "attribute_value_mlt": [{"subitem_description": "Article", "subitem_description_type": "Other"}]}, "item_6_description_5": {"attribute_name": "引用", "attribute_value_mlt": [{"subitem_description": "Bioscience, biotechnology, and biochemistry. 86(2): 260-272 (2022)", "subitem_description_type": "Other"}]}, "item_6_link_3": {"attribute_name": "信州大学研究者総覧へのリンク", "attribute_value_mlt": [{"subitem_link_text": "三谷, 塁一", "subitem_link_url": "https://soar-rd.shinshu-u.ac.jp/profile/ja.ypcCPUkh.html"}]}, "item_6_publisher_4": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Oxford University Press"}]}, "item_6_relation_47": {"attribute_name": "PubMed", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "34849563"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://pubmed.ncbi.nlm.nih.gov/34849563/", "subitem_relation_type_select": "PMID"}}]}, "item_6_relation_48": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "10.1093/bbb/zbab203"}], "subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1093/bbb/zbab203", "subitem_relation_type_select": "DOI"}}]}, "item_6_select_64": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "author"}]}, "item_6_source_id_35": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1347-6947", "subitem_source_identifier_type": "EISSN"}]}, "item_6_source_id_39": {"attribute_name": "NII ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1347-6947", "subitem_source_identifier_type": "EISSN"}]}, "item_6_source_id_40": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AA12018610", "subitem_source_identifier_type": "NCID"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Ikeda, Takahiro", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Watanabe, Shun", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Mitani, Takakazu", "creatorNameLang": "en"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2022-11-30"}], "download_preview_message": "", "file_order": 0, "filename": "BiosciBiotecBiochem86-260.pdf", "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 0, "url": {"label": "BiosciBiotecBiochem86-260.pdf", "url": "https://soar-ir.repo.nii.ac.jp/record/2000706/files/BiosciBiotecBiochem86-260.pdf"}, "version_id": "73eb4c4b-451a-4ef6-a3a3-74f1ec8a3a79"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "adipogenesis", "subitem_subject_scheme": "Other"}, {"subitem_subject": "AMPK", "subitem_subject_scheme": "Other"}, {"subitem_subject": "ANT2", "subitem_subject_scheme": "Other"}, {"subitem_subject": "genistein", "subitem_subject_scheme": "Other"}, {"subitem_subject": "target molecule", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Genistein regulates adipogenesis by blocking the function of adenine nucleotide translocase-2 in the mitochondria", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Genistein regulates adipogenesis by blocking the function of adenine nucleotide translocase-2 in the mitochondria", "subitem_title_language": "en"}]}, "item_type_id": "6", "owner": "1", "path": ["1222"], "permalink_uri": "http://hdl.handle.net/10091/0002000706", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2022-02-04"}, "publish_date": "2022-02-04", "publish_status": "0", "recid": "2000706", "relation": {}, "relation_version_is_last": true, "title": ["Genistein regulates adipogenesis by blocking the function of adenine nucleotide translocase-2 in the mitochondria"], "weko_shared_id": -1}
Genistein regulates adipogenesis by blocking the function of adenine nucleotide translocase-2 in the mitochondria
http://hdl.handle.net/10091/0002000706
http://hdl.handle.net/10091/0002000706