Item type |
学術雑誌論文 / Journal Article(1) |
公開日 |
2023-01-20 |
タイトル |
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タイトル |
Impact of extracellular matrix on engraftment and maturation of pluripotent stem cell-derived cardiomyocytes in a rat myocardial infarct model |
言語 |
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言語 |
eng |
DOI |
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関連タイプ |
isIdenticalTo |
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関連識別子 |
https://doi.org/10.1038/s41598-017-09217-x |
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関連名称 |
10.1038/s41598-017-09217-x |
資源タイプ |
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資源 |
http://purl.org/coar/resource_type/c_6501 |
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タイプ |
journal article |
著者 |
Ogasawara, Tatsuki
Okano, Satomi
Ichimura, Hajime
Kadota, Shin
Tanaka, Yuki
Minami, Itsunari
Uesugi, Motonari
Suzuki, Shuichiro
Wada, Yuko
Saito, Naoto
Okada, Kenji
Kuwahara, Koichiro
Shiba, Yuji
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信州大学研究者総覧へのリンク |
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氏名 |
市村, 創 |
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URL |
https://soar-rd.shinshu-u.ac.jp/profile/ja.WVchPpym.html |
信州大学研究者総覧へのリンク |
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氏名 |
門田, 真 |
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URL |
https://soar-rd.shinshu-u.ac.jp/profile/ja.OaSaPNym.html |
信州大学研究者総覧へのリンク |
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氏名 |
和田, 有子 |
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URL |
https://soar-rd.shinshu-u.ac.jp/profile/ja.jULpuNkh.html |
信州大学研究者総覧へのリンク |
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氏名 |
齋藤, 直人 |
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URL |
https://soar-rd.shinshu-u.ac.jp/profile/ja.WpkhuUkh.html |
信州大学研究者総覧へのリンク |
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氏名 |
桑原, 宏一郎 |
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URL |
https://soar-rd.shinshu-u.ac.jp/profile/ja.HVchWCcp.html |
信州大学研究者総覧へのリンク |
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氏名 |
柴, 祐司 |
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URL |
https://soar-rd.shinshu-u.ac.jp/profile/ja.ZCnmumkh.html |
出版者 |
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出版者 |
Springer Nature |
引用 |
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内容記述 |
Scientific reports 7(1) : 8630-(2017) |
書誌情報 |
Scientific reports
巻 7,
号 1,
p. 8630,
発行日 2017-08-17
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抄録 |
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内容記述 |
Pluripotent stem cell-derived cardiomyocytes show great promise in regenerating the heart after myocardial infarction; however, several uncertainties exist that must be addressed before clinical trials. One practical issue is graft survival following transplantation. Although a pro-survival cocktail with Matrigel has been shown to enhance graft survival, the use of Matrigel may not be clinically feasible. The purpose of this study was to test whether a hyaluronan-based hydrogel, HyStem, could be a substitute for Matrigel. Human induced pluripotent stem cell-derived cardiomyocytes diluted with HyStem alone, HyStem plus pro-survival factors, or a pro-survival cocktail with Matrigel (PSC/MG), were transplanted into a rat model of acute myocardial infarction. Histological analysis at 4 weeks post transplantation revealed that, among the three groups, recipients of PSC/MG showed the largest graft size. Additionally, the grafted cardiomyocytes in the recipients of PSC/MG had a more matured phenotype compared to those in the other two groups. These findings suggest that further studies will be required to enhance not only graft size, but also the maturation of grafted cardiomyocytes. |
資源タイプ(コンテンツの種類) |
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内容記述 |
Article |
ISSN |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
2045-2322 |
PubMed |
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関連識別子 |
https://pubmed.ncbi.nlm.nih.gov/28819182/ |
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関連名称 |
28819182 |
権利 |
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権利情報 |
© The Author(s) 2017 |
出版タイプ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |