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  1. 050 医学部, 大学院医学系研究科
  2. 0501 学術論文

Impact of extracellular matrix on engraftment and maturation of pluripotent stem cell-derived cardiomyocytes in a rat myocardial infarct model

http://hdl.handle.net/10091/0002001274
http://hdl.handle.net/10091/0002001274
a8e1c94c-4fad-456a-a38d-b1db5dec7888
名前 / ファイル ライセンス アクション
17H04173_1.pdf 17H04173_1.pdf
Item type 学術雑誌論文 / Journal Article(1)
公開日 2023-01-20
タイトル
言語 en
タイトル Impact of extracellular matrix on engraftment and maturation of pluripotent stem cell-derived cardiomyocytes in a rat myocardial infarct model
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Ogasawara, Tatsuki

× Ogasawara, Tatsuki

en Ogasawara, Tatsuki

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Okano, Satomi

× Okano, Satomi

en Okano, Satomi

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Ichimura, Hajime

× Ichimura, Hajime

en Ichimura, Hajime

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Kadota, Shin

× Kadota, Shin

en Kadota, Shin

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Tanaka, Yuki

× Tanaka, Yuki

en Tanaka, Yuki

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Minami, Itsunari

× Minami, Itsunari

en Minami, Itsunari

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Uesugi, Motonari

× Uesugi, Motonari

en Uesugi, Motonari

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Suzuki, Shuichiro

× Suzuki, Shuichiro

en Suzuki, Shuichiro

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Wada, Yuko

× Wada, Yuko

en Wada, Yuko

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Saito, Naoto

× Saito, Naoto

en Saito, Naoto

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Okada, Kenji

× Okada, Kenji

en Okada, Kenji

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Kuwahara, Koichiro

× Kuwahara, Koichiro

en Kuwahara, Koichiro

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Shiba, Yuji

× Shiba, Yuji

en Shiba, Yuji

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信州大学研究者総覧へのリンク
氏名 市村, 創
URL https://soar-rd.shinshu-u.ac.jp/profile/ja.WVchPpym.html
信州大学研究者総覧へのリンク
氏名 門田, 真
URL https://soar-rd.shinshu-u.ac.jp/profile/ja.OaSaPNym.html
信州大学研究者総覧へのリンク
氏名 和田, 有子
URL https://soar-rd.shinshu-u.ac.jp/profile/ja.jULpuNkh.html
信州大学研究者総覧へのリンク
氏名 齋藤, 直人
URL https://soar-rd.shinshu-u.ac.jp/profile/ja.WpkhuUkh.html
信州大学研究者総覧へのリンク
氏名 桑原, 宏一郎
URL https://soar-rd.shinshu-u.ac.jp/profile/ja.HVchWCcp.html
信州大学研究者総覧へのリンク
氏名 柴, 祐司
URL https://soar-rd.shinshu-u.ac.jp/profile/ja.ZCnmumkh.html
出版者
出版者 Springer Nature
引用
内容記述タイプ Other
内容記述 Scientific reports 7(1) : 8630-(2017)
書誌情報 Scientific reports

巻 7, 号 1, p. 8630, 発行日 2017-08-17
抄録
内容記述タイプ Abstract
内容記述 Pluripotent stem cell-derived cardiomyocytes show great promise in regenerating the heart after myocardial infarction; however, several uncertainties exist that must be addressed before clinical trials. One practical issue is graft survival following transplantation. Although a pro-survival cocktail with Matrigel has been shown to enhance graft survival, the use of Matrigel may not be clinically feasible. The purpose of this study was to test whether a hyaluronan-based hydrogel, HyStem, could be a substitute for Matrigel. Human induced pluripotent stem cell-derived cardiomyocytes diluted with HyStem alone, HyStem plus pro-survival factors, or a pro-survival cocktail with Matrigel (PSC/MG), were transplanted into a rat model of acute myocardial infarction. Histological analysis at 4 weeks post transplantation revealed that, among the three groups, recipients of PSC/MG showed the largest graft size. Additionally, the grafted cardiomyocytes in the recipients of PSC/MG had a more matured phenotype compared to those in the other two groups. These findings suggest that further studies will be required to enhance not only graft size, but also the maturation of grafted cardiomyocytes.
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Article
ISSN
収録物識別子タイプ EISSN
収録物識別子 2045-2322
PubMed
識別子タイプ PMID
関連識別子 https://pubmed.ncbi.nlm.nih.gov/28819182/
関連名称 28819182
DOI
関連タイプ isIdenticalTo
識別子タイプ DOI
関連識別子 https://doi.org/10.1038/s41598-017-09217-x
関連名称 10.1038/s41598-017-09217-x
権利
権利情報 © The Author(s) 2017
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
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