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Suppression of Mouse AApoAII Amyloidosis Progression by Daily Supplementation with Oxidative Stress Inhibitors
http://hdl.handle.net/10091/0002001277
http://hdl.handle.net/10091/0002001277dc185e11-ed21-4a3f-a091-22224b483a97
| 名前 / ファイル | ライセンス | アクション |
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17K19900_2.pdf
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||||||||||||
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| 公開日 | 2023-01-26 | |||||||||||||||||||||||
| タイトル | ||||||||||||||||||||||||
| タイトル | Suppression of Mouse AApoAII Amyloidosis Progression by Daily Supplementation with Oxidative Stress Inhibitors | |||||||||||||||||||||||
| 言語 | ||||||||||||||||||||||||
| 言語 | eng | |||||||||||||||||||||||
| DOI | ||||||||||||||||||||||||
| 関連タイプ | isIdenticalTo | |||||||||||||||||||||||
| 関連識別子 | https://doi.org/10.1155/2019/1263274 | |||||||||||||||||||||||
| 関連名称 | 10.1155/2019/1263274 | |||||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||||
| タイプ | journal article | |||||||||||||||||||||||
| 著者 |
Dai, Jian
× Dai, Jian
× Ding, Xin
× Miyahara, Hiroki
× Xu, Zhe
× Cui, Xiaoran
× Igarashi, Yuichi
× Sawashita, Jinko
× Mori, Masayuki
× Higuchi, Keiichi
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| 信州大学研究者総覧へのリンク | ||||||||||||||||||||||||
| 氏名 | 代, 健 | |||||||||||||||||||||||
| URL | https://soar-rd.shinshu-u.ac.jp/profile/ja.ZacNuhkh.html | |||||||||||||||||||||||
| 信州大学研究者総覧へのリンク | ||||||||||||||||||||||||
| 氏名 | 宮原, 大貴 | |||||||||||||||||||||||
| URL | https://soar-rd.shinshu-u.ac.jp/profile/ja.OhLmPNym.html | |||||||||||||||||||||||
| 信州大学研究者総覧へのリンク | ||||||||||||||||||||||||
| 氏名 | 森, 政之 | |||||||||||||||||||||||
| URL | https://soar-rd.shinshu-u.ac.jp/profile/ja.OpSCZafV.html | |||||||||||||||||||||||
| 信州大学研究者総覧へのリンク | ||||||||||||||||||||||||
| 氏名 | 樋口, 京一 | |||||||||||||||||||||||
| URL | https://soar-rd.shinshu-u.ac.jp/profile/ja.gCfUPmAh.html | |||||||||||||||||||||||
| 出版者 | ||||||||||||||||||||||||
| 出版者 | Hindawi Ltd. | |||||||||||||||||||||||
| 引用 | ||||||||||||||||||||||||
| 内容記述 | Oxidative medicine and cellular longevity 2019 : 1263274, (2019) | |||||||||||||||||||||||
| 書誌情報 |
Oxidative medicine and cellular longevity 巻 2019, p. 1263274, 発行日 2019-06-04 |
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| 抄録 | ||||||||||||||||||||||||
| 内容記述 | Amyloidosis is a group of diseases characterized by protein misfolding and aggregation to form amyloid fibrils and subsequent deposition within various tissues. Previous studies have indicated that amyloidosis is often associated with oxidative stress. However, it is not clear whether oxidative stress is involved in the progression of amyloidosis. We administered the oxidative stress inhibitors tempol and apocynin via drinking water to the R1.P1-Apoa2c mouse strain induced to develop mouse apolipoprotein A-II (AApoAII) amyloidosis and found that treatment with oxidative stress inhibitors led to reduction in AApoAII amyloidosis progression compared to an untreated group after 12 weeks, especially in the skin, stomach, and liver. There was no effect on ApoA-II plasma levels or expression of Apoa2 mRNA. Detection of the lipid peroxidation markers 4-hydroxynonenal (4-HNE) and malondialdehyde (MDA) revealed that the antioxidative effects of the treatments were most obvious in the skin, stomach, and liver, which contained higher levels of basal oxidative stress. Moreover, the unfolded protein response was reduced in the liver and was associated with a decrease in oxidative stress and amyloid deposition. These results suggest that antioxidants can suppress the progression of AApoAII amyloid deposition in the improved microenvironment of tissues and that the effect may be related to the levels of oxidative stress in local tissues. This finding provides insights for antioxidative stress treatment strategies for amyloidosis. | |||||||||||||||||||||||
| 資源タイプ（コンテンツの種類） | ||||||||||||||||||||||||
| ISSN | ||||||||||||||||||||||||
| 収録物識別子タイプ | EISSN | |||||||||||||||||||||||
| 収録物識別子 | 1942-0994 | |||||||||||||||||||||||
| PubMed | ||||||||||||||||||||||||
| 識別子タイプ | PMID | |||||||||||||||||||||||
| 関連識別子 | https://pubmed.ncbi.nlm.nih.gov/31281565/ | |||||||||||||||||||||||
| 関連名称 | 31281565 | |||||||||||||||||||||||
| 権利 | ||||||||||||||||||||||||
| 権利情報 | © 2019 Jian Dai et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | |||||||||||||||||||||||
| 出版タイプ | ||||||||||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||||||||
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Cite as
Dai, Jian, Ding, Xin, Miyahara, Hiroki, Xu, Zhe, Cui, Xiaoran, Igarashi, Yuichi, Sawashita, Jinko, Mori, Masayuki, Higuchi, Keiichi, 2019, Suppression of Mouse AApoAII Amyloidosis Progression by Daily Supplementation with Oxidative Stress Inhibitors: Hindawi Ltd., 1263274– p.
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