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  1. 050 医学部, 大学院医学系研究科
  2. 0501 学術論文

Glavonoid-rich oil supplementation reduces stearoyl-coenzyme A desaturase 1 expression and improves systemic metabolism in diabetic, obese KK-Ay mice

http://hdl.handle.net/10091/0002001278
http://hdl.handle.net/10091/0002001278
bba8502a-981d-44a8-840f-d91bb3c7d672
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17K19900_1.pdf 17K19900_1.pdf
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Item type 学術雑誌論文 / Journal Article(1)
公開日 2023-01-26
タイトル
タイトル Glavonoid-rich oil supplementation reduces stearoyl-coenzyme A desaturase 1 expression and improves systemic metabolism in diabetic, obese KK-Ay mice
言語
言語 eng
DOI
関連タイプ isIdenticalTo
関連識別子 https://doi.org/10.1016/j.biopha.2021.111714
関連名称 10.1016/j.biopha.2021.111714
キーワード
主題 Licorice flavonoid, Glabridin, Stearoyl-coenzyme A desaturase 1, KK-Ay mice, Lipid metabolism
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Igarashi, Yuichi

× Igarashi, Yuichi

en Igarashi, Yuichi

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Iida, Shiho

× Iida, Shiho

en Iida, Shiho

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Dai, Jian

× Dai, Jian

en Dai, Jian

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Huo, Jia

× Huo, Jia

en Huo, Jia

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Cui, Xiaoran

× Cui, Xiaoran

en Cui, Xiaoran

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Sawashita, Jinko

× Sawashita, Jinko

en Sawashita, Jinko

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Mori, Masayuki

× Mori, Masayuki

en Mori, Masayuki

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Miyahara, Hiroki

× Miyahara, Hiroki

en Miyahara, Hiroki

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Higuchi, Keiichi

× Higuchi, Keiichi

en Higuchi, Keiichi

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信州大学研究者総覧へのリンク
氏名 代, 健
URL https://soar-rd.shinshu-u.ac.jp/profile/ja.ZacNuhkh.html
信州大学研究者総覧へのリンク
氏名 森, 政之
URL https://soar-rd.shinshu-u.ac.jp/profile/ja.OpSCZafV.html
信州大学研究者総覧へのリンク
氏名 宮原, 大貴
URL https://soar-rd.shinshu-u.ac.jp/profile/ja.OhLmPNym.html
信州大学研究者総覧へのリンク
氏名 樋口, 京一
URL https://soar-rd.shinshu-u.ac.jp/profile/ja.gCfUPmAh.html
出版者
出版者 Elsevier
引用
内容記述 Biomedicine & pharmacotherapy 140 : 111714, (2021)
書誌情報 Biomedicine & pharmacotherapy

巻 140, p. 111714, 発行日 2021-08
抄録
内容記述 Aims: Glavonoid-rich oil (GRO) derived from ethanol extraction of licorice (Glycyrrhiza glabra Linne) root has been reported to have beneficial effects on health. In this study, we aimed to determine the effect of long-term administration of GRO on metabolic disorders and to elucidate the molecular mechanism. Main methods: Female obese, type 2 diabetic KK-Ay mice were fed diets supplemented with 0.3% or 0.8% GRO (w/w) for 4-12 weeks. Mice were euthanized and autopsied at 20 weeks old. The effects of GRO on lipid and glucose metabolism were evaluated by measuring physiological and biochemical markers using mRNA sequencing, quantitative reverse-transcription PCR, and western blot analyses. Key findings: Compared to mice fed the control diet, GRO-supplemented mice had reduced body and white adipose tissue weights, serum levels of triglycerides and cholesterol, and improved glucose tolerance, while food intake was not affected. We found remarkable reductions in the gene expression levels of stearoyl-coenzyme A desaturase 1 (Scd1) and pyruvate dehydrogenase kinase isoenzyme 4 (Pdk4) in the liver, in addition to decreased expression of fatty acid synthase (Fasn) in inguinal white adipose tissue (iWAT). These results suggest that GRO supplementation improves lipid profiles via reduced de novo lipogenesis in the liver and white adipose tissue. Glucose metabolism may also be improved by increased glycolysis in the liver. Significance: Our analysis of long-term supplementation of GRO in obese and diabetic mice should provide novel insight into preventing insulin resistance and metabolic syndromes.
資源タイプ(コンテンツの種類)
ISSN
収録物識別子タイプ EISSN
収録物識別子 1950-6007
PubMed
識別子タイプ PMID
関連識別子 https://pubmed.ncbi.nlm.nih.gov/34022607/
関連名称 34022607
権利
権利情報 © 2021 Published by Elsevier Masson SAS. This is an open access article under the CC BY-NC-ND license
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
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