| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2023-01-26 |
| タイトル |
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タイトル |
Glavonoid-rich oil supplementation reduces stearoyl-coenzyme A desaturase 1 expression and improves systemic metabolism in diabetic, obese KK-Ay mice |
| 言語 |
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言語 |
eng |
| DOI |
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|
関連タイプ |
isIdenticalTo |
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関連識別子 |
https://doi.org/10.1016/j.biopha.2021.111714 |
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関連名称 |
10.1016/j.biopha.2021.111714 |
| キーワード |
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主題 |
Licorice flavonoid, Glabridin, Stearoyl-coenzyme A desaturase 1, KK-Ay mice, Lipid metabolism |
| 資源タイプ |
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|
資源 |
http://purl.org/coar/resource_type/c_6501 |
|
タイプ |
journal article |
| 著者 |
Igarashi, Yuichi
Iida, Shiho
Dai, Jian
Huo, Jia
Cui, Xiaoran
Sawashita, Jinko
Mori, Masayuki
Miyahara, Hiroki
Higuchi, Keiichi
|
| 信州大学研究者総覧へのリンク |
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氏名 |
代, 健 |
|
URL |
https://soar-rd.shinshu-u.ac.jp/profile/ja.ZacNuhkh.html |
| 信州大学研究者総覧へのリンク |
|
|
氏名 |
森, 政之 |
|
URL |
https://soar-rd.shinshu-u.ac.jp/profile/ja.OpSCZafV.html |
| 信州大学研究者総覧へのリンク |
|
|
氏名 |
宮原, 大貴 |
|
URL |
https://soar-rd.shinshu-u.ac.jp/profile/ja.OhLmPNym.html |
| 信州大学研究者総覧へのリンク |
|
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氏名 |
樋口, 京一 |
|
URL |
https://soar-rd.shinshu-u.ac.jp/profile/ja.gCfUPmAh.html |
| 出版者 |
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出版者 |
Elsevier |
| 引用 |
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内容記述 |
Biomedicine & pharmacotherapy 140 : 111714, (2021) |
| 書誌情報 |
Biomedicine & pharmacotherapy
巻 140,
p. 111714,
発行日 2021-08
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| 抄録 |
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内容記述 |
Aims: Glavonoid-rich oil (GRO) derived from ethanol extraction of licorice (Glycyrrhiza glabra Linne) root has been reported to have beneficial effects on health. In this study, we aimed to determine the effect of long-term administration of GRO on metabolic disorders and to elucidate the molecular mechanism. Main methods: Female obese, type 2 diabetic KK-Ay mice were fed diets supplemented with 0.3% or 0.8% GRO (w/w) for 4-12 weeks. Mice were euthanized and autopsied at 20 weeks old. The effects of GRO on lipid and glucose metabolism were evaluated by measuring physiological and biochemical markers using mRNA sequencing, quantitative reverse-transcription PCR, and western blot analyses. Key findings: Compared to mice fed the control diet, GRO-supplemented mice had reduced body and white adipose tissue weights, serum levels of triglycerides and cholesterol, and improved glucose tolerance, while food intake was not affected. We found remarkable reductions in the gene expression levels of stearoyl-coenzyme A desaturase 1 (Scd1) and pyruvate dehydrogenase kinase isoenzyme 4 (Pdk4) in the liver, in addition to decreased expression of fatty acid synthase (Fasn) in inguinal white adipose tissue (iWAT). These results suggest that GRO supplementation improves lipid profiles via reduced de novo lipogenesis in the liver and white adipose tissue. Glucose metabolism may also be improved by increased glycolysis in the liver. Significance: Our analysis of long-term supplementation of GRO in obese and diabetic mice should provide novel insight into preventing insulin resistance and metabolic syndromes. |
| 資源タイプ（コンテンツの種類） |
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| ISSN |
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収録物識別子タイプ |
EISSN |
|
収録物識別子 |
1950-6007 |
| PubMed |
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識別子タイプ |
PMID |
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関連識別子 |
https://pubmed.ncbi.nlm.nih.gov/34022607/ |
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関連名称 |
34022607 |
| 権利 |
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権利情報 |
© 2021 Published by Elsevier Masson SAS. This is an open access article under the CC BY-NC-ND license |
| 出版タイプ |
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出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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