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Clinical Study of Pollen-food Allergy Syndrome Estimated by Double-blind, Placebo-controlled Food Challenges of Ten Apple Cultivars
http://hdl.handle.net/10091/0002001443
http://hdl.handle.net/10091/000200144399c3de2a-5c03-4fca-95b3-e0b4bfd2f121
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
shinshuishi71-2_2.pdf
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||||
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| 公開日 | 2023-04-14 | |||||||||||||||
| タイトル | ||||||||||||||||
| タイトル | Clinical Study of Pollen-food Allergy Syndrome Estimated by Double-blind, Placebo-controlled Food Challenges of Ten Apple Cultivars | |||||||||||||||
| 言語 | ||||||||||||||||
| 言語 | eng | |||||||||||||||
| DOI | ||||||||||||||||
| 関連タイプ | isIdenticalTo | |||||||||||||||
| 関連識別子 | https://doi.org/10.11441/shinshumedj.71.99 | |||||||||||||||
| 関連名称 | 10.11441/shinshumedj.71.99 | |||||||||||||||
| キーワード | ||||||||||||||||
| 主題 | pollen-food allergy syndrome, skin-prick test, visual analog scale, oral food challenge | |||||||||||||||
| 資源タイプ | ||||||||||||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||
| タイプ | journal article | |||||||||||||||
| 著者 |
Koike, Yumi
× Koike, Yumi
× Okishima, Naoko
× Tokunaga, Mai
× Kobayashi, Katsuhiko
× Inaba, Yuji
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| 信州大学研究者総覧へのリンク | ||||||||||||||||
| 氏名 | 沖嶋, 直子 | |||||||||||||||
| URL | https://soar-rd.shinshu-u.ac.jp/profile/ja.WpDUjNyC.html | |||||||||||||||
| 信州大学研究者総覧へのリンク | ||||||||||||||||
| 氏名 | 稲葉, 雄二 | |||||||||||||||
| URL | https://soar-rd.shinshu-u.ac.jp/profile/ja.ypLCuakh.html | |||||||||||||||
| 出版者 | ||||||||||||||||
| 出版者 | 信州医学会 | |||||||||||||||
| 引用 | ||||||||||||||||
| 内容記述 | 信州医学雑誌 71(2) : 99-107, (2023) | |||||||||||||||
| 書誌情報 |
信州医学雑誌 巻 71, 号 2, p. 99-107, 発行日 2023-04-10 |
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| 抄録 | ||||||||||||||||
| 内容記述 | Background : The number of patients with pollen-food allergy syndrome (PFAS) has increased globally. Apples are a major causative food for PFAS. Varied reports have demonstrated the usefulness of skin prick test (SPT) for the diagnosis of PFAS, besides differences in symptom expression among apple cultivars, thus the diagnosis of PFAS remains unclear. Purpose : To investigate the clinical features of apple-induced PFAS by performing a double-blind placebocontrolled food challenge (DBPCFC) using different apple cultivars on patients with apple-induced PFAS. Method : DBPCFC was performed for six patients with apple-induced PFAS using 10 apple cultivars. We measured the degree of symptoms using the Visual Analog Scale (VAS). Further, we assessed the correlations of Mal d 1 and Bet v 1-specific IgE levels and SPT findings to the VAS. Results : Three of six patients (50 ％) were VAS-positive for two apple cultivars, one patient each (17 ％) was positive for three, four, and five apple cultivars. The correlation between SPT findings and VAS was insignificant (p＝0.103). The VAS displayed a positive relationship with Mal d 1 and Bet v 1 (r＝0.5 and r＝0.84, respectively). Conclusion : It is necessary to perform DBPCFC with multiple apple cultivars to diagnose PFAS. The SPT was not useful in diagnosing PFAS ; however, Bet v 1-specific IgE levels may be advantageous. This novel clinical study of PFAS assessed multiple Japanese apple varieties, therefore, our findings can serve as a baseline for future studies. | |||||||||||||||
| 資源タイプ（コンテンツの種類） | ||||||||||||||||
| ISSN | ||||||||||||||||
| 収録物識別子タイプ | PISSN | |||||||||||||||
| 収録物識別子 | 0037-3826 | |||||||||||||||
| 書誌レコードID | ||||||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||||||
| 収録物識別子 | AN00120815 | |||||||||||||||
| 出版タイプ | ||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||
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Cite as
Koike, Yumi, Okishima, Naoko, Tokunaga, Mai, Kobayashi, Katsuhiko, Inaba, Yuji, 2023, Clinical Study of Pollen-food Allergy Syndrome Estimated by Double-blind, Placebo-controlled Food Challenges of Ten Apple Cultivars: 信州医学会, 99–107 p.
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