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  1. 050 医学部, 大学院医学系研究科
  2. 0502 紀要・刊行物
  3. 05021 信州医学雑誌
  4. Vol. 71 No. 2

Clinical Study of Pollen-food Allergy Syndrome Estimated by Double-blind, Placebo-controlled Food Challenges of Ten Apple Cultivars

http://hdl.handle.net/10091/0002001443
http://hdl.handle.net/10091/0002001443
99c3de2a-5c03-4fca-95b3-e0b4bfd2f121
名前 / ファイル ライセンス アクション
shinshuishi71-2_2.pdf shinshuishi71-2_2.pdf
Item type 学術雑誌論文 / Journal Article(1)
公開日 2023-04-14
タイトル
タイトル Clinical Study of Pollen-food Allergy Syndrome Estimated by Double-blind, Placebo-controlled Food Challenges of Ten Apple Cultivars
言語
言語 eng
DOI
関連タイプ isIdenticalTo
関連識別子 https://doi.org/10.11441/shinshumedj.71.99
関連名称 10.11441/shinshumedj.71.99
キーワード
主題 pollen-food allergy syndrome, skin-prick test, visual analog scale, oral food challenge
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Koike, Yumi

× Koike, Yumi

en Koike, Yumi

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Okishima, Naoko

× Okishima, Naoko

en Okishima, Naoko

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Tokunaga, Mai

× Tokunaga, Mai

en Tokunaga, Mai

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Kobayashi, Katsuhiko

× Kobayashi, Katsuhiko

en Kobayashi, Katsuhiko

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Inaba, Yuji

× Inaba, Yuji

en Inaba, Yuji

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信州大学研究者総覧へのリンク
氏名 沖嶋, 直子
URL https://soar-rd.shinshu-u.ac.jp/profile/ja.WpDUjNyC.html
信州大学研究者総覧へのリンク
氏名 稲葉, 雄二
URL https://soar-rd.shinshu-u.ac.jp/profile/ja.ypLCuakh.html
出版者
出版者 信州医学会
引用
内容記述 信州医学雑誌 71(2) : 99-107, (2023)
書誌情報 信州医学雑誌

巻 71, 号 2, p. 99-107, 発行日 2023-04-10
抄録
内容記述 Background : The number of patients with pollen-food allergy syndrome (PFAS) has increased globally. Apples are a major causative food for PFAS. Varied reports have demonstrated the usefulness of skin prick test (SPT) for the diagnosis of PFAS, besides differences in symptom expression among apple cultivars, thus the diagnosis of PFAS remains unclear. Purpose : To investigate the clinical features of apple-induced PFAS by performing a double-blind placebocontrolled food challenge (DBPCFC) using different apple cultivars on patients with apple-induced PFAS. Method : DBPCFC was performed for six patients with apple-induced PFAS using 10 apple cultivars. We measured the degree of symptoms using the Visual Analog Scale (VAS). Further, we assessed the correlations of Mal d 1 and Bet v 1-specific IgE levels and SPT findings to the VAS. Results : Three of six patients (50 %) were VAS-positive for two apple cultivars, one patient each (17 %) was positive for three, four, and five apple cultivars. The correlation between SPT findings and VAS was insignificant (p=0.103). The VAS displayed a positive relationship with Mal d 1 and Bet v 1 (r=0.5 and r=0.84, respectively). Conclusion : It is necessary to perform DBPCFC with multiple apple cultivars to diagnose PFAS. The SPT was not useful in diagnosing PFAS ; however, Bet v 1-specific IgE levels may be advantageous. This novel clinical study of PFAS assessed multiple Japanese apple varieties, therefore, our findings can serve as a baseline for future studies.
資源タイプ(コンテンツの種類)
ISSN
収録物識別子タイプ PISSN
収録物識別子 0037-3826
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AN00120815
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
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Koike, Yumi, Okishima, Naoko, Tokunaga, Mai, Kobayashi, Katsuhiko, Inaba, Yuji, 2023, Clinical Study of Pollen-food Allergy Syndrome Estimated by Double-blind, Placebo-controlled Food Challenges of Ten Apple Cultivars: 信州医学会, 99–107 p.

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