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抗PD-1抗体薬治療により長期の病勢コントロールが得られているMSI-H/dMMR 転移性上行結腸癌の１例
http://hdl.handle.net/10091/0002001663
http://hdl.handle.net/10091/0002001663f049685f-d8b7-4a6c-9c24-ad0d11595215
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
shinshuishi71-4_3.pdf
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| アイテムタイプ | 学術雑誌論文 / Journal Article(1) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2023-08-10 | |||||||||
| タイトル | ||||||||||
| タイトル | 抗PD-1抗体薬治療により長期の病勢コントロールが得られているMSI-H/dMMR 転移性上行結腸癌の１例 | |||||||||
| タイトル | ||||||||||
| タイトル | Programmed Death 1 Blockade Therapy with Long-lasting Disease Control in a Metastatic Ascending Colon Carcinoma with High-level Microsatellite Instability/Mismatch Repair Deficiency : Literature Review of the Case Report | |||||||||
| 言語 | ||||||||||
| 言語 | jpn | |||||||||
| DOI | ||||||||||
| 関連タイプ | isIdenticalTo | |||||||||
| 関連識別子 | https://doi.org/10.11441/shinshumedj.71.225 | |||||||||
| 関連名称 | 10.11441/shinshumedj.71.225 | |||||||||
| キーワード | ||||||||||
| 主題 | metastatic ascending colon cancer, mucinous carcinoma, MSI-H, Pembrolizumab 転移性上行結腸癌, 粘液癌, MSI-H, Pembrolizumab |
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| 資源タイプ | ||||||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| タイプ | journal article | |||||||||
| 著者 |
中村, 学
× 中村, 学
× 中山, 淳
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| 信州大学研究者総覧へのリンク | ||||||||||
| 氏名 | 中山, 淳 | |||||||||
| 研究者URL | https://soar-rd.shinshu-u.ac.jp/profile/ja.HCApHFkh.html | |||||||||
| 出版者 | ||||||||||
| 出版者 | 信州医学会 | |||||||||
| 引用 | ||||||||||
| 内容記述 | 信州医学雑誌 71(4) : 225-233, (2023) | |||||||||
| 書誌情報 |
信州医学雑誌 巻 71, 号 4, p. 225-233, 発行日 2023-08-10 |
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| 抄録 | ||||||||||
| 内容記述 | A 70-year-old woman was admitted to our hospital because of anemia with headache and nausea. As a result of anemia workup, she was diagnosed with ascending colon cancer with a para-aortic lymph node metastasis. Ileocecal resection and excision of an enlarged para-aortic lymph node were performed. Histopathological diagnosis of the resected specimen was poorly differentiated adenocarcinoma (solid type) with some mucinous carcinoma, and the metastatic lymph nodes showed differentiation into mucinous carcinoma. Immunohistologically, CD8＋T cell infiltration was observed in the cancer tissue, but mucinous carcinoma in the metastatic lymph nodes showed sparse CD8+T cell infiltration. During chemotherapy for liver metastases after surgery, lymph node metastases appeared near the hepatic hilum. The histology of lymph node metastases was diagnosed as mucinous carcinoma based on CT findings, and pembrolizumab was administered due to microsatellite instability-high.Twenty-two months after the start of treatment with pembrolizumab, the metastatic lymph nodes were judged to be in partial response and have maintained the reduction. The disappearance of liver metastases was confirmed 25 months after the start of pembrolizumab treatment. In our case, the time to partial response in the metastatic lymph nodes was longer than the reported median time to objective response to pembrolizumab. It is possible that the differentiation into mucinous carcinoma at the metastatic site caused the suppression of the infiltration of CD8-positive T cells into cancer cell clusters. The difference in time to response between mucinous and non-mucinous carcinoma in patients treated with immune checkpoint inhibitor is a matter for further study. | |||||||||
| 資源タイプ（コンテンツの種類） | ||||||||||
| ISSN | ||||||||||
| 収録物識別子タイプ | PISSN | |||||||||
| 収録物識別子 | 0037-3826 | |||||||||
| 書誌レコードID | ||||||||||
| 収録物識別子タイプ | NCID | |||||||||
| 収録物識別子 | AN00120815 | |||||||||
| 出版タイプ | ||||||||||
| 出版タイプ | VoR | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||
