| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2018-09-12 |
| タイトル |
|
|
タイトル |
Electronegative Low-density Lipoprotein Increases Coronary Artery Disease Risk in Uremia Patients on Maintenance Hemodialysis |
| 言語 |
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|
言語 |
eng |
| DOI |
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|
関連識別子 |
https://doi.org/10.1097/MD.0000000000002265 |
|
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関連名称 |
10.1097/MD.0000000000002265 |
| 資源タイプ |
|
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資源 |
http://purl.org/coar/resource_type/c_6501 |
|
タイプ |
journal article |
| 著者 |
Chang, CT
Wang, GJ
Kuo, CC
Hsieh, JY
Lee, AS
Chang, CM
Wang, CC
Shen, MY
Huang, CC
Sawamura, T
Yang, CY
Stancel, N
Chen, CH
|
| 信州大学研究者総覧へのリンク |
|
|
氏名 |
Sawamura, Tatsuya |
|
URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.HafpjeAF.html |
| 出版者 |
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|
出版者 |
LIPPINCOTT WILLIAMS & WILKINS |
| 引用 |
|
|
内容記述 |
MEDICINE.95(2):e2265(2016) |
| 書誌情報 |
MEDICINE
巻 95,
号 2,
p. e2265,
発行日 2016-01
|
| 抄録 |
|
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内容記述 |
Electronegative low-density lipoprotein (LDL) is a recognized factor in the pathogenesis of coronary artery disease (CAD) in the general population, but its role in the development of CAD in uremia patients is unknown. L5 is the most electronegative subfraction of LDL isolated from human plasma. In this study, we examined the distribution of L5 (L5%) and its association with CAD risk in uremia patients.<br/>The LDL of 39 uremia patients on maintenance hemodialysis and 21 healthy controls was separated into 5 subfractions, L1–L5, with increasing electronegativity. We compared the distribution and composition of plasma L5 between uremia patients and controls, examined the association between plasma L5% and CAD risk in uremia patients, and studied the effects of L5 from uremia patients on endothelial function.<br/>Compared to controls, uremia patients had significantly increased L5% (P < 0.001) and L5 that was rich in apolipoprotein C3 and triglycerides. L5% was significantly higher in uremia patients with CAD (n = 10) than in those without CAD (n = 29) (P < 0.05). Independent of other major CAD risk factors, the adjusted odds ratio for CAD was 1.88 per percent increase in plasma L5% (95% CI, 1.01–3.53), with a near-linear dose–response relationship. Compared with controls, uremia patients had decreased flow-mediated vascular dilatation. In ex vivo studies with preconstricted rat thoracic aortic rings, L5 from uremia patients inhibited acetylcholine-induced relaxation. In cultured human endothelial cells, L5 inhibited endothelial nitric oxide synthase activation and induced endothelial dysfunction.<br/>Our findings suggest that elevated plasma L5% may induce endothelial dysfunction and play an important role in the increased risk of CAD in uremia patients. |
| 資源タイプ（コンテンツの種類） |
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| ISSN |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
0025-7974 |
| 書誌レコードID |
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収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA12542695 |
| PubMed |
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|
識別子タイプ |
PMID |
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関連識別子 |
https://www.ncbi.nlm.nih.gov/pubmed/26765403 |
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|
関連名称 |
26765403 |
| 権利 |
|
|
権利情報 |
© 2016 Wolters Kluwer Health, Inc. All rights reserved. This is an open access article distributed under the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| WoS |
|
|
URL |
http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000370602900001 |
25293063_02.pdf (512.2 kB)
