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The Biphasic Effects of Oxidized-Low Density Lipoprotein on the Vasculogenic Function of Endothelial Progenitor Cells
http://hdl.handle.net/10091/00020845
http://hdl.handle.net/10091/000208459135bb7a-f23c-46ef-aeeb-d0875025282e
| 名前 / ファイル | ライセンス | アクション |
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25293063_08.pdf (4.4 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||||||||||||||
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| 公開日 | 2018-09-12 | |||||||||||||||||||||||||
| タイトル | ||||||||||||||||||||||||||
| タイトル | The Biphasic Effects of Oxidized-Low Density Lipoprotein on the Vasculogenic Function of Endothelial Progenitor Cells | |||||||||||||||||||||||||
| 言語 | ||||||||||||||||||||||||||
| 言語 | eng | |||||||||||||||||||||||||
| DOI | ||||||||||||||||||||||||||
| 関連識別子 | https://doi.org/10.1371/journal.pone.0123971 | |||||||||||||||||||||||||
| 関連名称 | 10.1371/journal.pone.0123971 | |||||||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||||||
| タイプ | journal article | |||||||||||||||||||||||||
| 著者 |
Lin, FY
× Lin, FY
× Tsao, NW
× Shih, CM
× Lin, YW
× Yeh, JS
× Chen, JW
× Nakagami, H
× Morishita, R
× Sawamura, T
× Huang, CY
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| 信州大学研究者総覧へのリンク | ||||||||||||||||||||||||||
| 氏名 | Sawamura, Tatsuya | |||||||||||||||||||||||||
| URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.HafpjeAF.html | |||||||||||||||||||||||||
| 出版者 | ||||||||||||||||||||||||||
| 出版者 | PUBLIC LIBRARY SCIENCE | |||||||||||||||||||||||||
| 引用 | ||||||||||||||||||||||||||
| 内容記述 | PLOS ONE.10(5):e0123971(2015) | |||||||||||||||||||||||||
| 書誌情報 |
PLOS ONE 巻 10, 号 5, p. e0123971, 発行日 2015-05-27 |
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| 抄録 | ||||||||||||||||||||||||||
| 内容記述 | Late-outgrowth endothelial progenitor cells (EPCs) are stress-resistant and responsible for reparative functions in the cardiovascular system. Oxidized-LDL (oxLDL) plays a critical role in cardiovascular disease pathogenesis. However, it is largely unknown what the impacts of oxLDL are on late-outgrowth EPCs. This study aimed to investigate the concentration-related effects of oxLDL on EPC functions and related angiogenesis, in vitro and in vivo. In this study, early and late-outgrowth EPCs were generated from circulating human mononuclear cells. oxLDL may regulate EPC vasculogenic function via the lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1). Lower concentrations (5 μg/mL) of oxLDL can potentiate EPC tube formation in vitro and in vivo by activating eNOS mechanisms, which are mediated by p38 MAPK- and SAPK/JNK-related pathways. Higher concentrations of oxLDL (10-50 μg/mL) impaired EPC function via the activation of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase pathways and consequent inhibition of eNOS activity, which could be reversed by anti-oxidants (diphenylene iodonium and apocynin) and gp91phox siRNA. In conclusion, oxLDL has concentration-dependent biphasic effects on human late-outgrowth EPC tube formation in vitro and in vivo. | |||||||||||||||||||||||||
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| 収録物識別子タイプ | PISSN | |||||||||||||||||||||||||
| 収録物識別子 | 1932-6203 | |||||||||||||||||||||||||
| PubMed | ||||||||||||||||||||||||||
| 識別子タイプ | PMID | |||||||||||||||||||||||||
| 関連識別子 | https://www.ncbi.nlm.nih.gov/pubmed/26017136 | |||||||||||||||||||||||||
| 関連名称 | 26017136 | |||||||||||||||||||||||||
| 権利 | ||||||||||||||||||||||||||
| 権利情報 | © 2015 Lin et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited | |||||||||||||||||||||||||
| 出版タイプ | ||||||||||||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||||||||||
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| URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=3&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000355185600002 | |||||||||||||||||||||||||
