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  1. 050 医学部, 大学院医学系研究科
  2. 0501 学術論文

The Biphasic Effects of Oxidized-Low Density Lipoprotein on the Vasculogenic Function of Endothelial Progenitor Cells

http://hdl.handle.net/10091/00020845
http://hdl.handle.net/10091/00020845
9135bb7a-f23c-46ef-aeeb-d0875025282e
名前 / ファイル ライセンス アクション
25293063_08.pdf 25293063_08.pdf (4.4 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2018-09-12
タイトル
タイトル The Biphasic Effects of Oxidized-Low Density Lipoprotein on the Vasculogenic Function of Endothelial Progenitor Cells
言語
言語 eng
DOI
関連識別子 https://doi.org/10.1371/journal.pone.0123971
関連名称 10.1371/journal.pone.0123971
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Lin, FY

× Lin, FY

en Lin, FY

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Tsao, NW

× Tsao, NW

en Tsao, NW

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Shih, CM

× Shih, CM

en Shih, CM

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Lin, YW

× Lin, YW

en Lin, YW

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Yeh, JS

× Yeh, JS

en Yeh, JS

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Chen, JW

× Chen, JW

en Chen, JW

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Nakagami, H

× Nakagami, H

en Nakagami, H

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Morishita, R

× Morishita, R

en Morishita, R

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Sawamura, T

× Sawamura, T

en Sawamura, T

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Huang, CY

× Huang, CY

en Huang, CY

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信州大学研究者総覧へのリンク
氏名 Sawamura, Tatsuya
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.HafpjeAF.html
出版者
出版者 PUBLIC LIBRARY SCIENCE
引用
内容記述 PLOS ONE.10(5):e0123971(2015)
書誌情報 PLOS ONE

巻 10, 号 5, p. e0123971, 発行日 2015-05-27
抄録
内容記述 Late-outgrowth endothelial progenitor cells (EPCs) are stress-resistant and responsible for reparative functions in the cardiovascular system. Oxidized-LDL (oxLDL) plays a critical role in cardiovascular disease pathogenesis. However, it is largely unknown what the impacts of oxLDL are on late-outgrowth EPCs. This study aimed to investigate the concentration-related effects of oxLDL on EPC functions and related angiogenesis, in vitro and in vivo. In this study, early and late-outgrowth EPCs were generated from circulating human mononuclear cells. oxLDL may regulate EPC vasculogenic function via the lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1). Lower concentrations (5 μg/mL) of oxLDL can potentiate EPC tube formation in vitro and in vivo by activating eNOS mechanisms, which are mediated by p38 MAPK- and SAPK/JNK-related pathways. Higher concentrations of oxLDL (10-50 μg/mL) impaired EPC function via the activation of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase pathways and consequent inhibition of eNOS activity, which could be reversed by anti-oxidants (diphenylene iodonium and apocynin) and gp91phox siRNA. In conclusion, oxLDL has concentration-dependent biphasic effects on human late-outgrowth EPC tube formation in vitro and in vivo.
資源タイプ(コンテンツの種類)
ISSN
収録物識別子タイプ PISSN
収録物識別子 1932-6203
PubMed
識別子タイプ PMID
関連識別子 https://www.ncbi.nlm.nih.gov/pubmed/26017136
関連名称 26017136
権利
権利情報 © 2015 Lin et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
WoS
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=3&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000355185600002
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