| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2018-09-12 |
| タイトル |
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|
タイトル |
High-salt in addition to high-fat diet may enhance inflammation and fibrosis in liver steatosis induced by oxidative stress and dyslipidemia in mice |
| 言語 |
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|
言語 |
eng |
| DOI |
|
|
|
関連識別子 |
https://doi.org/10.1186/s12944-015-0002-9 |
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関連名称 |
10.1186/s12944-015-0002-9 |
| キーワード |
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主題 |
High salt diet induced oxidative stress, Oxidative stress, NADPH oxidase, Anti-oxidant tempol, Nonalcoholic fatty liver disease |
| 資源タイプ |
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|
資源 |
http://purl.org/coar/resource_type/c_6501 |
|
タイプ |
journal article |
| 著者 |
Uetake, Y
Ikeda, H
Irie, R
Tejima, K
Matsui, H
Ogura, S
Wang, H
Mu, SY
Hirohama, D
Ando, K
Sawamura, T
Yatomi, Y
Fujita, T
Shimosawa, T
|
| 信州大学研究者総覧へのリンク |
|
|
氏名 |
Sawamura, Tatsuya |
|
URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.HafpjeAF.html |
| 出版者 |
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出版者 |
BIOMED CENTRAL LTD |
| 引用 |
|
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内容記述 |
LIPIDS IN HEALTH AND DISEASE.14:6(2015) |
| 書誌情報 |
LIPIDS IN HEALTH AND DISEASE
巻 14,
p. 6,
発行日 2015-02-13
|
| 抄録 |
|
|
内容記述 |
Background: It is widely known that salt is an accelerating factor for the progression of metabolic syndrome and causes cardiovascular diseases, most likely due to its pro-oxidant properties. We hypothesized that excessive salt intake also facilitates the development of nonalcoholic steatohepatitis (NASH), which is frequently associated with metabolic syndrome.<br/>Methods: We examined the exacerbating effect of high-salt diet on high-fat diet-induced liver injury in a susceptible model to oxidative stress, apoE knockout and lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) transgenic mice.<br/>Results: High-salt diet led to NASH in high-fat diet-fed LOX-1 transgenic/apoE knockout mice without affecting high-fat diet-induced dyslipidemia or hepatic triglyceride accumulation. Additionally, a high-salt and high-fat diet stimulated oxidative stress production and inflammatory reaction to a greater extent than did a high-fat diet in the liver of LOX-1 transgenic/apoE knockout mice.<br/>Conclusions: We demonstrated that high-salt diet exacerbated NASH in high-fat diet-fed LOX-1 transgenic /apoE knockout mice and that this effect was associated with the stimulation of oxidative and inflammatory processes; this is the first study to suggest the important role of excessive salt intake in the development of NASH. |
| 資源タイプ（コンテンツの種類） |
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| ISSN |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
1476-511X |
| 書誌レコードID |
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収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA1203677X |
| PubMed |
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識別子タイプ |
PMID |
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関連識別子 |
https://www.ncbi.nlm.nih.gov/pubmed/25888871 |
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|
関連名称 |
25888871 |
| 権利 |
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|
権利情報 |
© 2015 Uetake et al.; licensee BioMed Central. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
| 出版タイプ |
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|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| WoS |
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|
URL |
http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=4&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000350068200001 |
25293063_11.pdf (2.7 MB)
