{"_buckets": {"deposit": "b935a10e-cdbb-4b0e-817e-1cb97239b5f8"}, "_deposit": {"id": "20085", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "20085"}, "status": "published"}, "_oai": {"id": "oai:soar-ir.repo.nii.ac.jp:00020085", "sets": ["462"]}, "author_link": ["106197", "106198", "106199", "106200", "106201", "106202", "106203", "106204", "106205", "106206", "106207", "106208", "106209", "106210"], "item_1628147817048": {"attribute_name": "出版タイプ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_6_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2015-02-13", "bibliographicIssueDateType": "Issued"}, "bibliographicPageStart": "6", "bibliographicVolumeNumber": "14", "bibliographic_titles": [{"bibliographic_title": "LIPIDS IN HEALTH AND DISEASE"}]}]}, "item_6_description_20": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Background: It is widely known that salt is an accelerating factor for the progression of metabolic syndrome and causes cardiovascular diseases, most likely due to its pro-oxidant properties. We hypothesized that excessive salt intake also facilitates the development of nonalcoholic steatohepatitis (NASH), which is frequently associated with metabolic syndrome.\u003cbr/\u003eMethods: We examined the exacerbating effect of high-salt diet on high-fat diet-induced liver injury in a susceptible model to oxidative stress, apoE knockout and lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) transgenic mice.\u003cbr/\u003eResults: High-salt diet led to NASH in high-fat diet-fed LOX-1 transgenic/apoE knockout mice without affecting high-fat diet-induced dyslipidemia or hepatic triglyceride accumulation. Additionally, a high-salt and high-fat diet stimulated oxidative stress production and inflammatory reaction to a greater extent than did a high-fat diet in the liver of LOX-1 transgenic/apoE knockout mice.\u003cbr/\u003eConclusions: We demonstrated that high-salt diet exacerbated NASH in high-fat diet-fed LOX-1 transgenic /apoE knockout mice and that this effect was associated with the stimulation of oxidative and inflammatory processes; this is the first study to suggest the important role of excessive salt intake in the development of NASH.", "subitem_description_type": "Abstract"}]}, "item_6_description_30": {"attribute_name": "資源タイプ（コンテンツの種類）", "attribute_value_mlt": [{"subitem_description": "Article", "subitem_description_type": "Other"}]}, "item_6_description_5": {"attribute_name": "引用", "attribute_value_mlt": [{"subitem_description": "LIPIDS IN HEALTH AND DISEASE.14:6(2015)", "subitem_description_type": "Other"}]}, "item_6_link_3": {"attribute_name": "信州大学研究者総覧へのリンク", "attribute_value_mlt": [{"subitem_link_text": "Sawamura, Tatsuya", "subitem_link_url": "http://soar-rd.shinshu-u.ac.jp/profile/ja.HafpjeAF.html"}]}, "item_6_link_67": {"attribute_name": "WoS", "attribute_value_mlt": [{"subitem_link_text": "Web of Science", "subitem_link_url": "http://gateway.isiknowledge.com/gateway/Gateway.cgi?\u0026GWVersion=4\u0026SrcAuth=ShinshuUniv\u0026SrcApp=ShinshuUniv\u0026DestLinkType=FullRecord\u0026DestApp=WOS\u0026KeyUT=000350068200001"}]}, "item_6_publisher_4": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "BIOMED CENTRAL LTD"}]}, "item_6_relation_47": {"attribute_name": "PubMed", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "25888871"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://www.ncbi.nlm.nih.gov/pubmed/25888871", "subitem_relation_type_select": "PMID"}}]}, "item_6_relation_48": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "10.1186/s12944-015-0002-9"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1186/s12944-015-0002-9", "subitem_relation_type_select": "DOI"}}]}, "item_6_rights_62": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "© 2015 Uetake et al.; licensee BioMed Central. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated."}]}, "item_6_select_64": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_6_source_id_35": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1476-511X", "subitem_source_identifier_type": "PISSN"}]}, "item_6_source_id_39": {"attribute_name": "NII ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1476-511X", "subitem_source_identifier_type": "PISSN"}]}, "item_6_source_id_40": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AA1203677X", "subitem_source_identifier_type": "NCID"}]}, "item_6_text_69": {"attribute_name": "wosonly authkey", "attribute_value_mlt": [{"subitem_text_value": "High salt diet induced oxidative stress; Oxidative stress; NADPH oxidase; Anti-oxidant tempol; Nonalcoholic fatty liver disease"}]}, "item_6_text_70": {"attribute_name": "wosonly keywords", "attribute_value_mlt": [{"subitem_text_value": "LOW-DENSITY-LIPOPROTEIN; NONALCOHOLIC STEATOHEPATITIS; SENSITIVE HYPERTENSION; INSULIN-RESISTANCE; HEPATIC STEATOSIS; FOLLOW-UP; VITAMIN-E; DISEASE; INJURY; OBESITY"}]}, "item_6_textarea_68": {"attribute_name": "wosonly abstract", "attribute_value_mlt": [{"subitem_textarea_value": "Background: It is widely known that salt is an accelerating factor for the progression of metabolic syndrome and causes cardiovascular diseases, most likely due to its pro-oxidant properties. We hypothesized that excessive salt intake also facilitates the development of nonalcoholic steatohepatitis (NASH), which is frequently associated with metabolic syndrome. \u003cbr/\u003eMethods: We examined the exacerbating effect of high-salt diet on high-fat diet-induced liver injury in a susceptible model to oxidative stress, apoE knockout and lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) transgenic mice. \u003cbr/\u003eResults: High-salt diet led to NASH in high-fat diet-fed LOX-1 transgenic/apoE knockout mice without affecting high-fat diet-induced dyslipidemia or hepatic triglyceride accumulation. Additionally, a high-salt and high-fat diet stimulated oxidative stress production and inflammatory reaction to a greater extent than did a high-fat diet in the liver of LOX-1 transgenic/apoE knockout mice. \u003cbr/\u003eConclusions: We demonstrated that high-salt diet exacerbated NASH in high-fat diet-fed LOX-1 transgenic /apoE knockout mice and that this effect was associated with the stimulation of oxidative and inflammatory processes; this is the first study to suggest the important role of excessive salt intake in the development of NASH."}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Uetake, Y", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "106197", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ikeda, H", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "106198", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Irie, R", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "106199", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tejima, K", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "106200", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Matsui, H", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "106201", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ogura, S", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "106202", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Wang, H", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "106203", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Mu, SY", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "106204", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hirohama, D", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "106205", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ando, K", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "106206", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sawamura, T", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "106207", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yatomi, Y", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "106208", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Fujita, T", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "106209", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Shimosawa, T", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "106210", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-09-12"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "25293063_11.pdf", "filesize": [{"value": "2.7 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensefree": "© 2015 Uetake et al.; licensee BioMed Central. 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