ログイン
言語:

WEKO3

  • トップ
  • ランキング


インデックスリンク

インデックスツリー

  • RootNode

メールアドレスを入力してください。

WEKO

One fine body…

WEKO

One fine body…

アイテム

  1. 050 医学部, 大学院医学系研究科
  2. 0501 学術論文

Human Serum Amyloid A3 (SAA3) Protein, Expressed as a Fusion Protein with SAA2, Binds the Oxidized Low Density Lipoprotein Receptor

http://hdl.handle.net/10091/00020847
http://hdl.handle.net/10091/00020847
ff46eedb-7634-4fc2-93d4-45cb8ed41089
名前 / ファイル ライセンス アクション
25293063_12.pdf 25293063_12.pdf (1.6 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2018-09-12
タイトル
タイトル Human Serum Amyloid A3 (SAA3) Protein, Expressed as a Fusion Protein with SAA2, Binds the Oxidized Low Density Lipoprotein Receptor
言語
言語 eng
DOI
関連識別子 https://doi.org/10.1371/journal.pone.0118835
関連名称 10.1371/journal.pone.0118835
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Tomita, T

× Tomita, T

en Tomita, T

Search repository
Ieguchi, K

× Ieguchi, K

en Ieguchi, K

Search repository
Sawamura, T

× Sawamura, T

en Sawamura, T

Search repository
Maru, Y

× Maru, Y

en Maru, Y

Search repository
信州大学研究者総覧へのリンク
氏名 Sawamura, Tatsuya
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.HafpjeAF.html
出版者
出版者 PUBLIC LIBRARY SCIENCE
引用
内容記述 PLOS ONE.10(3):e0118835(2015)
書誌情報 PLOS ONE

巻 10, 号 3, p. e0118835, 発行日 2015-03-04
抄録
内容記述 Serum amyloid A3 (SAA3) possesses characteristics distinct from the other serum amyloid A isoforms, SAA1, SAA2, and SAA4. High density lipoprotein contains the latter three isoforms, but not SAA3. The expression of mouse SAA3 (mSAA3) is known to be up-regulated extrahepatically in inflammatory responses, and acts as an endogenous ligand for the toll-like receptor 4/MD-2 complex. We previously reported that mSAA3 plays an important role in facilitating tumor metastasis by attracting circulating tumor cells and enhancing hyperpermeability in the lungs. On the other hand, human SAA3 (hSAA3) has long been regarded as a pseudogene, which is in contrast to the abundant expression levels of the other isoforms. Although the nucleotide sequence of hSAA3 is very similar to that of the other SAAs, a single oligonucleotide insertion in exon 2 causes a frame-shift to generate a unique amino acid sequence. In the present study, we identified that hSAA3 was transcribed in the hSAA2-SAA3 fusion transcripts of several human cell lines. In the fusion transcript, hSAA2 exon 3 was connected to hSAA3 exon 1 or hSAA3 exon 2, located approximately 130kb downstream from hSAA2 exon 3 in the genome, which suggested that it is produced by alternative splicing. Furthermore, we succeeded in detecting and isolating hSAA3 protein for the first time by an immunoprecipitation-enzyme linked immune assay system using monoclonal and polyclonal antibodies that recognize the hSAA3 unique amino acid sequence. We also demonstrated that hSAA3 bound oxidized low density lipoprotein receptor (oxLDL receptor, LOX-1) and elevated the phosphorylation of ERK, the intracellular MAP-kinase signaling protein.
資源タイプ(コンテンツの種類)
ISSN
収録物識別子タイプ PISSN
収録物識別子 1932-6203
PubMed
識別子タイプ PMID
関連識別子 https://www.ncbi.nlm.nih.gov/pubmed/25738827
関連名称 25738827
権利
権利情報 © 2015 Tomita et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
WoS
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=5&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000350685900078
戻る
0
views
See details
Views

Versions

Ver.1 2021-03-01 08:15:23.770755
Show All versions

Share

Mendeley Twitter Facebook Print Addthis

Cite as

Tomita, T, Ieguchi, K, Sawamura, T, Maru, Y, 2015, Human Serum Amyloid A3 (SAA3) Protein, Expressed as a Fusion Protein with SAA2, Binds the Oxidized Low Density Lipoprotein Receptor: PUBLIC LIBRARY SCIENCE, e0118835– p.

Loading...

エクスポート

OAI-PMH
  • OAI-PMH JPCOAR 2.0
  • OAI-PMH JPCOAR 1.0
  • OAI-PMH DublinCore
  • OAI-PMH DDI
Other Formats
  • JSON
  • BIBTEX

Confirm


Powered by WEKO3


Powered by WEKO3