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Cannabidiol induces expression of human cytochrome P450 1A1 that is possibly mediated through aryl hydrocarbon receptor signaling in HepG2 cells
http://hdl.handle.net/10091/00020868
http://hdl.handle.net/10091/00020868499cb87a-1489-4581-97f6-ebffe5787c00
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
Manuscript (LifeSci 2015 Yamaori).pdf (454.0 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||||||
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| 公開日 | 2018-09-18 | |||||||||||||||||
| タイトル | ||||||||||||||||||
| タイトル | Cannabidiol induces expression of human cytochrome P450 1A1 that is possibly mediated through aryl hydrocarbon receptor signaling in HepG2 cells | |||||||||||||||||
| 言語 | ||||||||||||||||||
| 言語 | eng | |||||||||||||||||
| DOI | ||||||||||||||||||
| 関連識別子 | https://doi.org/10.1016/j.lfs.2015.07.007 | |||||||||||||||||
| 関連名称 | 10.1016/j.lfs.2015.07.007 | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 主題 | Marijuana, Cannabidiol, CYP1A1, Induction, AhR, Protein tyrosine kinase | |||||||||||||||||
| 資源タイプ | ||||||||||||||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||
| タイプ | journal article | |||||||||||||||||
| 著者 |
Yamaori, Satoshi
× Yamaori, Satoshi
× Kinugasa, Yuka
× Jiang, Rongrong
× Takeda, Shuso
× Yamamoto, Ikuo
× Watanabe, Kazuhito
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| 信州大学研究者総覧へのリンク | ||||||||||||||||||
| 氏名 | Yamaori, Satoshi | |||||||||||||||||
| URL | https://soar-rd.shinshu-u.ac.jp/profile/ja.jefNgUkh.html | |||||||||||||||||
| 出版者 | ||||||||||||||||||
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD | |||||||||||||||||
| 引用 | ||||||||||||||||||
| 内容記述 | LIFE SCIENCES.136:87-93(2015) | |||||||||||||||||
| 書誌情報 |
LIFE SCIENCES 巻 136, p. 87-93, 発行日 2015-09-01 |
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| 抄録 | ||||||||||||||||||
| 内容記述 | Aims<br/>We herein investigated the inducibility of cytochrome P450 1A1 (CYP1A1) by Δ9-tetrahydrocannabinol, cannabidiol (CBD), and cannabinol, three major phytocannabinoids, using human hepatoma HepG2 cells.<br/>Main methods<br/>The expression of CYP1A1 and the aryl hydrocarbon receptor (AhR) was measured by a quantitative real-time polymerase chain reaction and/or Western blotting.<br/>Key findings<br/>Δ9-Tetrahydrocannabinol and CBD concentration-dependently induced the expression of CYP1A1 mRNA, whereas cannabinol showed little or no induction. Among the phytocannabinoids tested, CBD was the most potent inducer of CYP1A1 expression. The induction of CYP1A1 expression by CBD was significantly attenuated by the knockdown of AhR expression with AhR small interfering RNAs. The role of protein tyrosine kinases (PTKs) in the CBD-mediated induction of CYP1A1 was then examined using herbimycin A, a PTK inhibitor. The upregulation of CYP1A1 by CBD was significantly suppressed by herbimycin A as was the induction by omeprazole but not 3-methylcholanthrene. The inducibility of CYP1A1 by CBD-related compounds was examined to clarify the structural requirements for CBD-mediated CYP1A1 induction. Olivetol, which corresponds to the pentylresorcinol moiety of CBD, significantly induced the expression of CYP1A1, whereas d-limonene, CBD-2′-monomethyl ether, and CBD-2′,6′-dimethyl ether did not.<br/>Significance<br/>These results showed that CBD may have induced human CYP1A1 expression through the activation of PTK-dependent AhR signaling, in which two phenolic hydroxyl groups in the pentylresorcinol moiety of CBD may play structurally important roles. | |||||||||||||||||
| 資源タイプ（コンテンツの種類） | ||||||||||||||||||
| ISSN | ||||||||||||||||||
| 収録物識別子タイプ | PISSN | |||||||||||||||||
| 収録物識別子 | 0024-3205 | |||||||||||||||||
| 書誌レコードID | ||||||||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||||||||
| 収録物識別子 | AA00717011 | |||||||||||||||||
| PubMed | ||||||||||||||||||
| 識別子タイプ | PMID | |||||||||||||||||
| 関連識別子 | https://www.ncbi.nlm.nih.gov/pubmed/26187180 | |||||||||||||||||
| 関連名称 | 26187180 | |||||||||||||||||
| 出版タイプ | ||||||||||||||||||
| 出版タイプ | AM | |||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||||||||||
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| URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000361035500013 | |||||||||||||||||
