{"_buckets": {"deposit": "f0aa7e92-f4a7-4832-85b2-4db966709ef1"}, "_deposit": {"id": "20214", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "20214"}, "status": "published"}, "_oai": {"id": "oai:soar-ir.repo.nii.ac.jp:00020214", "sets": ["462"]}, "author_link": ["106523", "106524", "106525", "106526", "106527", "106528", "106529", "106530", "106531", "106532", "106533", "106534", "106535", "106536", "106537"], "item_1628147817048": {"attribute_name": "出版タイプ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_6_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2018-10-05", "bibliographicIssueDateType": "Issued"}, "bibliographicPageEnd": "6088", "bibliographicPageStart": "6079", "bibliographicVolumeNumber": "13", "bibliographic_titles": [{"bibliographic_title": "INTERNATIONAL JOURNAL OF NANOMEDICINE"}]}]}, "item_6_description_20": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Introduction: Carbon nanotubes (CNTs) have various shapes, including needle-like shapes and curled shapes, and the cytotoxicity and carcinogenicity of CNTs differ depending on their shapes and surface modifications. However, the biological responses induced by CNTs and related mechanisms according to the dispersion state of CNTs have not been extensively studied.\u003cbr/\u003eMaterials and methods: We prepared multiwalled CNTs (MWCNTs) showing different dispersions and evaluated these MWCNTs in RAW264 cells to determine cytotoxicity, cellular uptake, and immune responses. Furthermore, RAW264 cells were also used to compare the cellular uptake and cytotoxicity of fibrous MWCNTs and spherical carbon nanohorns (CNHs) exhibiting the same degree of dispersion.\u003cbr/\u003eResults: Our analysis showed that the cellular uptake, localization, and inflammatory responses of MWCNTs differed depending on the dispersion state. Moreover, there were differences in uptake between MWCNTs and CNHs, even showing the same degree of dispersion. These findings suggested that receptors related to cytotoxicity and immune responses differed depending on the aggregated state of MWCNTs and surface modification with a dispersant. Furthermore, our results suggested that the receptors recognized by the cells differed depending on the particle shape.\u003cbr/\u003eConclusion: Therefore, to apply MWCNTs as a biomaterial, it is important to determine the carcinogenicity and toxicity of the CNTs and to examine different biological responses induced by varying shapes, dispersion states, and surface modifications of particles.", "subitem_description_type": "Abstract"}]}, "item_6_description_30": {"attribute_name": "資源タイプ（コンテンツの種類）", "attribute_value_mlt": [{"subitem_description": "Article", "subitem_description_type": "Other"}]}, "item_6_description_5": {"attribute_name": "引用", "attribute_value_mlt": [{"subitem_description": "INTERNATIONAL JOURNAL OF NANOMEDICINE. 13:6079-6088(2018)", "subitem_description_type": "Other"}]}, "item_6_link_3": {"attribute_name": "信州大学研究者総覧へのリンク", "attribute_value_mlt": [{"subitem_link_text": "Haniu, Hisao", "subitem_link_url": "http://soar-rd.shinshu-u.ac.jp/profile/ja.jakpPmSa.html"}, {"subitem_link_text": "Takizawa, Takashi", "subitem_link_url": "http://soar-rd.shinshu-u.ac.jp/profile/ja.OhTebVym.html"}, {"subitem_link_text": "Yoshida, Kazushige", "subitem_link_url": "http://soar-rd.shinshu-u.ac.jp/profile/ja.ZeyVPUym.html"}, {"subitem_link_text": "Okamoto, Masanori", "subitem_link_url": "http://soar-rd.shinshu-u.ac.jp/profile/ja.uafabVym.html"}, {"subitem_link_text": "Aoki, Kaoru", "subitem_link_url": "http://soar-rd.shinshu-u.ac.jp/profile/ja.WeDpbhym.html"}, {"subitem_link_text": "Kato, Hiroyuki", "subitem_link_url": "http://soar-rd.shinshu-u.ac.jp/profile/ja.WVkCbaSp.html"}, {"subitem_link_text": "Saito, Naoto", "subitem_link_url": "http://soar-rd.shinshu-u.ac.jp/profile/ja.WpkhuUkh.html"}]}, "item_6_link_67": {"attribute_name": "WoS", "attribute_value_mlt": [{"subitem_link_text": "Web of Science", "subitem_link_url": "http://gateway.isiknowledge.com/gateway/Gateway.cgi?\u0026GWVersion=2\u0026SrcAuth=ShinshuUniv\u0026SrcApp=ShinshuUniv\u0026DestLinkType=FullRecord\u0026DestApp=WOS\u0026KeyUT=000446671900003"}]}, "item_6_publisher_4": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "DOVE MEDICAL PRESS LTD"}]}, "item_6_relation_47": {"attribute_name": "PubMed", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "30323595"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://www.ncbi.nlm.nih.gov/pubmed/30323595", "subitem_relation_type_select": "PMID"}}]}, "item_6_relation_48": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "10.2147/IJN.S172493"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.2147/IJN.S172493", "subitem_relation_type_select": "DOI"}}]}, "item_6_rights_62": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "© 2018 Kuroda et al. This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php)"}]}, "item_6_select_64": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_6_source_id_35": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1178-2013", "subitem_source_identifier_type": "PISSN"}]}, "item_6_source_id_39": {"attribute_name": "NII ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1178-2013", "subitem_source_identifier_type": "PISSN"}]}, "item_6_text_69": {"attribute_name": "wosonly authkey", "attribute_value_mlt": [{"subitem_text_value": "multiwalled carbon nanotubes; aggregation; carbon nanohoms; cytotoxicity; immune response; cellular uptake"}]}, "item_6_text_70": {"attribute_name": "wosonly keywords", "attribute_value_mlt": [{"subitem_text_value": "SCAVENGER RECEPTOR; MOUSE MACROPHAGES; IN-VITRO; NANOTUBES; CYTOTOXICITY; PATHWAY; NANOPARTICLES; SYSTEM; MARCO; LUNG"}]}, "item_6_textarea_68": {"attribute_name": "wosonly abstract", "attribute_value_mlt": [{"subitem_textarea_value": "Introduction: Carbon nanotubes (CNTs) have various shapes, including needle-like shapes and curled shapes, and the cytotoxicity and carcinogenicity of CNTs differ depending on their shapes and surface modifications. However, the biological responses induced by CNTs and related mechanisms according to the dispersion state of CNTs have not been extensively studied. \u003cbr/\u003eMaterials and methods: We prepared multi walled CNTs (MWCNTs) showing different dispersions and evaluated these MWCNTs in RAW264 cells to determine cytotoxicity, cellular uptake, and immune responses. Furthermore, RAW264 cells were also used to compare the cellular uptake and cytotoxicity of fibrous MWCNTs and spherical carbon nanohoms (CNHs) exhibiting the same degree of dispersion. \u003cbr/\u003eResults: Our analysis showed that the cellular uptake, localization, and inflammatory responses of MWCNTs differed depending on the dispersion state. Moreover, there were differences in uptake between MWCNTs and CNHs, even showing the same degree of dispersion. These findings suggested that receptors related to cytotoxicity and immune responses di tiered depending on the aggregated state of MWCNTs and surface modification with a dispersant. Furthermore, our results suggested that the receptors recognized by the cells differed depending on the particle shape. \u003cbr/\u003eConclusion: Therefore, to apply MWCNTs as a biomaterial, it is important to determine the carcinogenicity and toxicity of the CNTs and to examine different biological responses induced by varying shapes, dispersion states, and surface modifications of particles."}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Kuroda, Chika", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "106523", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ueda, Katsuya", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "106524", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Haniu, Hisao", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "106525", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": 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