| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2018-10-30 |
| タイトル |
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タイトル |
Different aggregation and shape characteristics of carbon materials affect biological responses in RAW264 cells |
| 言語 |
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言語 |
eng |
| DOI |
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関連識別子 |
https://doi.org/10.2147/IJN.S172493 |
|
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関連名称 |
10.2147/IJN.S172493 |
| キーワード |
|
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主題 |
multiwalled carbon nanotubes, aggregation, carbon nanohorns, cytotoxicity, immune response, cellular uptake |
| 資源タイプ |
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資源 |
http://purl.org/coar/resource_type/c_6501 |
|
タイプ |
journal article |
| 著者 |
Kuroda, Chika
Ueda, Katsuya
Haniu, Hisao
Ishida, Haruka
Okano, Satomi
Takizawa, Takashi
Sobajima, Atsushi
Kamanaka, Takayuki
Yoshida, Kazushige
Okamoto, Masanori
Tsukahara, Tamotsu
Matsuda, Yoshikazu
Aoki, Kaoru
Kato, Hiroyuki
Saito, Naoto
|
| 信州大学研究者総覧へのリンク |
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氏名 |
Haniu, Hisao |
|
URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.jakpPmSa.html |
| 信州大学研究者総覧へのリンク |
|
|
氏名 |
Takizawa, Takashi |
|
URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.OhTebVym.html |
| 信州大学研究者総覧へのリンク |
|
|
氏名 |
Yoshida, Kazushige |
|
URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.ZeyVPUym.html |
| 信州大学研究者総覧へのリンク |
|
|
氏名 |
Okamoto, Masanori |
|
URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.uafabVym.html |
| 信州大学研究者総覧へのリンク |
|
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氏名 |
Aoki, Kaoru |
|
URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.WeDpbhym.html |
| 信州大学研究者総覧へのリンク |
|
|
氏名 |
Kato, Hiroyuki |
|
URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.WVkCbaSp.html |
| 信州大学研究者総覧へのリンク |
|
|
氏名 |
Saito, Naoto |
|
URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.WpkhuUkh.html |
| 出版者 |
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出版者 |
DOVE MEDICAL PRESS LTD |
| 引用 |
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内容記述 |
INTERNATIONAL JOURNAL OF NANOMEDICINE. 13:6079-6088(2018) |
| 書誌情報 |
INTERNATIONAL JOURNAL OF NANOMEDICINE
巻 13,
p. 6079-6088,
発行日 2018-10-05
|
| 抄録 |
|
|
内容記述 |
Introduction: Carbon nanotubes (CNTs) have various shapes, including needle-like shapes and curled shapes, and the cytotoxicity and carcinogenicity of CNTs differ depending on their shapes and surface modifications. However, the biological responses induced by CNTs and related mechanisms according to the dispersion state of CNTs have not been extensively studied.<br/>Materials and methods: We prepared multiwalled CNTs (MWCNTs) showing different dispersions and evaluated these MWCNTs in RAW264 cells to determine cytotoxicity, cellular uptake, and immune responses. Furthermore, RAW264 cells were also used to compare the cellular uptake and cytotoxicity of fibrous MWCNTs and spherical carbon nanohorns (CNHs) exhibiting the same degree of dispersion.<br/>Results: Our analysis showed that the cellular uptake, localization, and inflammatory responses of MWCNTs differed depending on the dispersion state. Moreover, there were differences in uptake between MWCNTs and CNHs, even showing the same degree of dispersion. These findings suggested that receptors related to cytotoxicity and immune responses differed depending on the aggregated state of MWCNTs and surface modification with a dispersant. Furthermore, our results suggested that the receptors recognized by the cells differed depending on the particle shape.<br/>Conclusion: Therefore, to apply MWCNTs as a biomaterial, it is important to determine the carcinogenicity and toxicity of the CNTs and to examine different biological responses induced by varying shapes, dispersion states, and surface modifications of particles. |
| 資源タイプ（コンテンツの種類） |
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| ISSN |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
1178-2013 |
| PubMed |
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識別子タイプ |
PMID |
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関連識別子 |
https://www.ncbi.nlm.nih.gov/pubmed/30323595 |
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関連名称 |
30323595 |
| 権利 |
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|
権利情報 |
© 2018 Kuroda et al. This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php) |
| 出版タイプ |
|
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出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| WoS |
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|
URL |
http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000446671900003 |
ijn-172493-different-aggregation-and-shape-characteristics-of-carbon-ma-100418.pdf (3.0 MB)
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