ログイン
言語:

WEKO3

  • トップ
  • コミュニティ
  • ランキング
AND
To
lat lon distance
To

Field does not validate



インデックスリンク

インデックスツリー

メールアドレスを入力してください。

WEKO

One fine body…

WEKO

One fine body…

アイテム

{"_buckets": {"deposit": "e064ff38-e126-4048-90bb-4fd570fb38eb"}, "_deposit": {"id": "20216", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "20216"}, "status": "published"}, "_oai": {"id": "oai:soar-ir.repo.nii.ac.jp:00020216", "sets": ["882:883"]}, "author_link": ["106556", "106557", "106558", "106559", "106560", "106561", "106562", "106563", "106564", "106565", "106566", "106567", "106568", "106569", "106570", "106571", "106572"], "item_1628147817048": {"attribute_name": "\u51fa\u7248\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_6_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2014-05-14", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "5", "bibliographicPageStart": "e0125938", "bibliographicVolumeNumber": "10", "bibliographic_titles": [{"bibliographic_title": "PLOS ONE"}]}]}, "item_6_description_20": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "Objectives\u003cbr/\u003eThe genotype-phenotype correlation of MEFV remains unclear for the familial Mediterranean fever (FMF) patients, especially without canonical MEFV mutations in exon 10. The risk of FMF appeared to be under the influence of other factors in this case. The contribution of HLA polymorphisms to the risk of FMF was examined as strong candidates of modifier genes.\u003cbr/\u003eMethods\u003cbr/\u003eGenotypes of HLA-B and -DRB1 loci were determined for 258 mutually unrelated Japanese FMF patients, who satisfied modified Tel-Hashomer criteria, and 299 healthy controls. The effects of carrier status were evaluated for the risk of FMF by odds ratio (OR). The HLA effects were also assessed for clinical forms of FMF, subsets of FMF with certain MEFV genotypes and responsiveness to colchicine treatment.\u003cbr/\u003eResults\u003cbr/\u003eThe carriers of B*39:01 were increased in the patients (OR = 3.25, p = 0.0012), whereas those of DRB1*15:02 were decreased (OR = 0.45, p = 0.00050), satisfying Bonferroni\u2019s correction for multiple statistical tests (n = 28, p\u003c0.00179). The protective effect of DRB1*15:02 was completely disappeared in the co-existence of B*40:01. The HLA effects were generally augmented in the patients without a canonical MEFV variant allele M694I, in accordance with the notion that the lower penetrance of the mutations is owing to the larger contribution of modifier genes in the pathogenesis, with a few exceptions. Further, 42.9% of 14 colchicine-resistant patients and 13.5% of 156 colchicine-responders possessed B*35:01 allele, giving OR of 4.82 (p = 0.0041).\u003cbr/\u003eConclusions\u003cbr/\u003eThe differential effects of HLA class I and class II polymorphisms were identified for Japanese FMF even in those with high-penetrance MEFV mutations.", "subitem_description_type": "Abstract"}]}, "item_6_description_30": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7\uff08\u30b3\u30f3\u30c6\u30f3\u30c4\u306e\u7a2e\u985e\uff09", "attribute_value_mlt": [{"subitem_description": "Article", "subitem_description_type": "Other"}]}, "item_6_description_5": {"attribute_name": "\u5f15\u7528", "attribute_value_mlt": [{"subitem_description": "PLOS ONE.10(5):e0125938(2014)", "subitem_description_type": "Other"}]}, "item_6_link_3": {"attribute_name": "\u4fe1\u5dde\u5927\u5b66\u7814\u7a76\u8005\u7dcf\u89a7\u3078\u306e\u30ea\u30f3\u30af", "attribute_value_mlt": [{"subitem_link_text": "Kishida, Dai", "subitem_link_url": "https://soar-rd.shinshu-u.ac.jp/profile/ja.uUSVPpym.html"}]}, "item_6_link_67": {"attribute_name": "WoS", "attribute_value_mlt": [{"subitem_link_text": "Web of Science", "subitem_link_url": "http://gateway.isiknowledge.com/gateway/Gateway.cgi?\u0026GWVersion=2\u0026SrcAuth=ShinshuUniv\u0026SrcApp=ShinshuUniv\u0026DestLinkType=FullRecord\u0026DestApp=WOS\u0026KeyUT=000354545600033"}]}, "item_6_publisher_4": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "PUBLIC LIBRARY SCIENCE"}]}, "item_6_relation_47": {"attribute_name": "PubMed", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "25974247"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://www.ncbi.nlm.nih.gov/pubmed/25974247", "subitem_relation_type_select": "PMID"}}]}, "item_6_relation_48": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "10.1371/journal.pone.0125938"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1371/journal.pone.0125938", "subitem_relation_type_select": "DOI"}}]}, "item_6_rights_62": {"attribute_name": "\u6a29\u5229", "attribute_value_mlt": [{"subitem_rights": "\u00a9 2015 Yasunami et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited"}]}, "item_6_select_64": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_6_source_id_35": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1932-6203", "subitem_source_identifier_type": "EISSN"}]}, "item_6_source_id_39": {"attribute_name": "NII ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1932-6203", "subitem_source_identifier_type": "EISSN"}]}, "item_6_text_70": {"attribute_name": "wosonly keywords", "attribute_value_mlt": [{"subitem_text_value": "ANKYLOSING-SPONDYLITIS; BEHCETS-DISEASE; RHEUMATOID-ARTHRITIS; ASSOCIATION; MEFV; SUSCEPTIBILITY; SPONDYLARTHROPATHIES; COLCHICINE; DIAGNOSIS; ALLELES"}]}, "item_6_textarea_68": {"attribute_name": "wosonly abstract", "attribute_value_mlt": [{"subitem_textarea_value": "Objectives \u003cbr/\u003eThe genotype-phenotype correlation of MEFV remains unclear for the familial Mediterranean fever (FMF) patients, especially without canonical MEFV mutations in exon 10. The risk of FMF appeared to be under the influence of other factors in this case. The contribution of HLA polymorphisms to the risk of FMF was examined as strong candidates of modifier genes. \u003cbr/\u003eMethods \u003cbr/\u003eGenotypes of HLA-B and -DRB1 loci were determined for 258 mutually unrelated Japanese FMF patients, who satisfied modified Tel-Hashomer criteria, and 299 healthy controls. The effects of carrier status were evaluated for the risk of FMF by odds ratio (OR). The HLA effects were also assessed for clinical forms of FMF, subsets of FMF with certain MEFV genotypes and responsiveness to colchicine treatment. \u003cbr/\u003eResults \u003cbr/\u003eThe carriers of B*39:01 were increased in the patients (OR = 3.25, p = 0.0012), whereas those of DRB1*15:02 were decreased (OR = 0.45, p = 0.00050), satisfying Bonferroni\u0027s correction for multiple statistical tests (n = 28, p\u003c0.00179). The protective effect of DRB1*15:02 was completely disappeared in the co-existence of B*40:01. The HLA effects were generally augmented in the patients without a canonical MEFV variant allele M694I, in accordance with the notion that the lower penetrance of the mutations is owing to the larger contribution of modifier genes in the pathogenesis, with a few exceptions. Further, 42.9% of 14 colchicine-resistant patients and 13.5% of 156 colchicine-responders possessed B*35:01 allele, giving OR of 4.82 (p = 0.0041). \u003cbr/\u003eConclusions \u003cbr/\u003eThe differential effects of HLA class I and class II polymorphisms were identified for Japanese FMF even in those with high-penetrance MEFV mutations."}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Yasunami, Michio", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "106556", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nakamura, Hitomi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "106557", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Agematsu, Kazunaga", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "106558", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nakamura, Akinori", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "106559", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yazaki, Masahide", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "106560", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kishida, Dai", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "106561", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yachie, Akihiro", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "106562", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Toma, Tomoko", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "106563", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Masumoto, Junya", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "106564", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ida, Hiroaki"}], "nameIdentifiers": [{"nameIdentifier": "106565", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Koga, Tomohiro", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "106566", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kawakami, Atsushi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "106567", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Eguchi, Katsumi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "106568", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Furukawa, Hiroshi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "106569", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nakamura, Tadashi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "106570", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nakamura, Minoru", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "106571", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Migita, Kiyoshi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "106572", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-10-31"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "journal.pone.0125938.PDF", "filesize": [{"value": "185.1 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensefree": "\u00a9 2015 Yasunami et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited", "licensetype": "license_note", "mimetype": "application/pdf", "size": 185100.0, "url": {"label": "journal.pone.0125938.PDF", "url": "https://soar-ir.repo.nii.ac.jp/record/20216/files/journal.pone.0125938.PDF"}, "version_id": "7bcdce52-f070-47e1-bff9-8ab4870e753a"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Identification of Disease-Promoting HLA Class I and Protective Class II Modifiers in Japanese Patients with Familial Mediterranean Fever", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Identification of Disease-Promoting HLA Class I and Protective Class II Modifiers in Japanese Patients with Familial Mediterranean Fever", "subitem_title_language": "en"}]}, "item_type_id": "6", "owner": "1", "path": ["882/883"], "permalink_uri": "http://hdl.handle.net/10091/00020974", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2018-10-31"}, "publish_date": "2018-10-31", "publish_status": "0", "recid": "20216", "relation": {}, "relation_version_is_last": true, "title": ["Identification of Disease-Promoting HLA Class I and Protective Class II Modifiers in Japanese Patients with Familial Mediterranean Fever"], "weko_shared_id": -1}
  1. 055 医学部附属病院
  2. 0551 学術論文

Identification of Disease-Promoting HLA Class I and Protective Class II Modifiers in Japanese Patients with Familial Mediterranean Fever

http://hdl.handle.net/10091/00020974
e66386dc-a4ef-4bb1-b335-c456d56105ea
名前 / ファイル ライセンス アクション
journal.pone.0125938.PDF journal.pone.0125938.PDF (185.1 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2018-10-31
タイトル
言語 en
タイトル Identification of Disease-Promoting HLA Class I and Protective Class II Modifiers in Japanese Patients with Familial Mediterranean Fever
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Yasunami, Michio

× Yasunami, Michio

WEKO 106556

en Yasunami, Michio

Search repository
Nakamura, Hitomi

× Nakamura, Hitomi

WEKO 106557

en Nakamura, Hitomi

Search repository
Agematsu, Kazunaga

× Agematsu, Kazunaga

WEKO 106558

en Agematsu, Kazunaga

Search repository
Nakamura, Akinori

× Nakamura, Akinori

WEKO 106559

en Nakamura, Akinori

Search repository
Yazaki, Masahide

× Yazaki, Masahide

WEKO 106560

en Yazaki, Masahide

Search repository
Kishida, Dai

× Kishida, Dai

WEKO 106561

en Kishida, Dai

Search repository
Yachie, Akihiro

× Yachie, Akihiro

WEKO 106562

en Yachie, Akihiro

Search repository
Toma, Tomoko

× Toma, Tomoko

WEKO 106563

en Toma, Tomoko

Search repository
Masumoto, Junya

× Masumoto, Junya

WEKO 106564

en Masumoto, Junya

Search repository
Ida, Hiroaki

× Ida, Hiroaki

WEKO 106565

Ida, Hiroaki

Search repository
Koga, Tomohiro

× Koga, Tomohiro

WEKO 106566

en Koga, Tomohiro

Search repository
Kawakami, Atsushi

× Kawakami, Atsushi

WEKO 106567

en Kawakami, Atsushi

Search repository
Eguchi, Katsumi

× Eguchi, Katsumi

WEKO 106568

en Eguchi, Katsumi

Search repository
Furukawa, Hiroshi

× Furukawa, Hiroshi

WEKO 106569

en Furukawa, Hiroshi

Search repository
Nakamura, Tadashi

× Nakamura, Tadashi

WEKO 106570

en Nakamura, Tadashi

Search repository
Nakamura, Minoru

× Nakamura, Minoru

WEKO 106571

en Nakamura, Minoru

Search repository
Migita, Kiyoshi

× Migita, Kiyoshi

WEKO 106572

en Migita, Kiyoshi

Search repository
信州大学研究者総覧へのリンク
氏名 Kishida, Dai
URL https://soar-rd.shinshu-u.ac.jp/profile/ja.uUSVPpym.html
出版者
出版者 PUBLIC LIBRARY SCIENCE
引用
内容記述タイプ Other
内容記述 PLOS ONE.10(5):e0125938(2014)
書誌情報 PLOS ONE

巻 10, 号 5, p. e0125938, 発行日 2014-05-14
抄録
内容記述タイプ Abstract
内容記述 Objectives<br/>The genotype-phenotype correlation of MEFV remains unclear for the familial Mediterranean fever (FMF) patients, especially without canonical MEFV mutations in exon 10. The risk of FMF appeared to be under the influence of other factors in this case. The contribution of HLA polymorphisms to the risk of FMF was examined as strong candidates of modifier genes.<br/>Methods<br/>Genotypes of HLA-B and -DRB1 loci were determined for 258 mutually unrelated Japanese FMF patients, who satisfied modified Tel-Hashomer criteria, and 299 healthy controls. The effects of carrier status were evaluated for the risk of FMF by odds ratio (OR). The HLA effects were also assessed for clinical forms of FMF, subsets of FMF with certain MEFV genotypes and responsiveness to colchicine treatment.<br/>Results<br/>The carriers of B*39:01 were increased in the patients (OR = 3.25, p = 0.0012), whereas those of DRB1*15:02 were decreased (OR = 0.45, p = 0.00050), satisfying Bonferroni’s correction for multiple statistical tests (n = 28, p<0.00179). The protective effect of DRB1*15:02 was completely disappeared in the co-existence of B*40:01. The HLA effects were generally augmented in the patients without a canonical MEFV variant allele M694I, in accordance with the notion that the lower penetrance of the mutations is owing to the larger contribution of modifier genes in the pathogenesis, with a few exceptions. Further, 42.9% of 14 colchicine-resistant patients and 13.5% of 156 colchicine-responders possessed B*35:01 allele, giving OR of 4.82 (p = 0.0041).<br/>Conclusions<br/>The differential effects of HLA class I and class II polymorphisms were identified for Japanese FMF even in those with high-penetrance MEFV mutations.
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Article
ISSN
収録物識別子タイプ EISSN
収録物識別子 1932-6203
PubMed
関連識別子
識別子タイプ PMID
関連識別子 https://www.ncbi.nlm.nih.gov/pubmed/25974247
関連名称
関連名称 25974247
DOI
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1371/journal.pone.0125938
関連名称
関連名称 10.1371/journal.pone.0125938
権利
権利情報 © 2015 Yasunami et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
WoS
表示名 Web of Science
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000354545600033
戻る
0
views
See details
Views

Versions

Ver.1 2021-03-01 08:09:11.537521
Show All versions

Share

Mendeley CiteULike Twitter Facebook Print Addthis

Cite as

Export

OAI-PMH
  • OAI-PMH JPCOAR
  • OAI-PMH DublinCore
  • OAI-PMH DDI
Other Formats
  • JSON
  • BIBTEX

Confirm


Powered by CERN Data Centre & Invenio


Powered by CERN Data Centre & Invenio