| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2018-10-31 |
| タイトル |
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タイトル |
A three-dimensional block structure consisting exclusively of carbon nanotubes serving as bone regeneration scaffold and as bone defect filler |
| 言語 |
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言語 |
eng |
| DOI |
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関連識別子 |
https://doi.org/10.1371/journal.pone.0172601 |
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関連名称 |
10.1371/journal.pone.0172601 |
| 資源タイプ |
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資源 |
http://purl.org/coar/resource_type/c_6501 |
|
タイプ |
journal article |
| 著者 |
Tanaka, Manabu
Sato, Yoshinori
Haniu, Hisao
Nomura, Hiroki
Kobayashi, Shinsuke
Takanashi, Seiji
Okamoto, Masanori
Takizawa, Takashi
Aoki, Kaoru
Usui, Yuki
Oishi, Ayumu
Kato, Hiroyuki
Saito, Naoto
|
| 信州大学研究者総覧へのリンク |
|
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氏名 |
Haniu, Hisao |
|
URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.jakpPmSa.html |
| 信州大学研究者総覧へのリンク |
|
|
氏名 |
Okamoto, Masanori |
|
URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.uafabVym.html |
| 信州大学研究者総覧へのリンク |
|
|
氏名 |
Aoki, Kaoru |
|
URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.WeDpbhym.html |
| 信州大学研究者総覧へのリンク |
|
|
氏名 |
Kato, Hiroyuki |
|
URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.WVkCbaSp.html |
| 信州大学研究者総覧へのリンク |
|
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氏名 |
Saito, Naoto |
|
URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.WpkhuUkh.html |
| 出版者 |
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出版者 |
PUBLIC LIBRARY SCIENCE |
| 引用 |
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内容記述 |
PLOS ONE.12(2):e0172601(2017) |
| 書誌情報 |
PLOS ONE
巻 12,
号 2,
p. e0172601,
発行日 2017-02-24
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| 抄録 |
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内容記述 |
Many recent studies have been conducted to assess the ability of composite materials containing carbon nanotubes (CNTs) with high bone affinity to serve as scaffolds in bone regenerative medicine. These studies have demonstrated that CNTs can effectively induce bone formation. However, no studies have investigated the usefulness of scaffolds consisting exclusively of CNTs in bone regenerative medicine. We built a three-dimensional block entity with maximized mechanical strength from multi-walled CNTs (MWCNT blocks) and evaluated their efficacy as scaffold material for bone repair. When MWCNT blocks containing recombinant human bone morphogenetic protein-2 (rhBMP-2) were implanted in mouse muscle, ectopic bone was formed in direct contact with the blocks. Their bone marrow densities were comparable to those of PET-reinforced collagen sheets with rhBMP-2. On day 1 and day 3, MC3T3-E1 preosteoblasts were attached to the scaffold surface of MWCNT blocks than that of PET-reinforced collagen sheets. They also showed a maximum compression strength comparable to that of cortical bone. Our MWCNT blocks are expected to serve as bone defect filler and scaffold material for bone regeneration. |
| 資源タイプ（コンテンツの種類） |
|
| ISSN |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
1932-6203 |
| PubMed |
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|
識別子タイプ |
PMID |
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関連識別子 |
https://www.ncbi.nlm.nih.gov/pubmed/28235026 |
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関連名称 |
28235026 |
| 権利 |
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権利情報 |
© 2017 Tanaka et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited |
| 出版タイプ |
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出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| WoS |
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|
URL |
http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000394688200098 |
journal.pone.0172601.pdf (3.1 MB)
