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  1. 050 医学部, 大学院医学系研究科
  2. 0501 学術論文

A three-dimensional block structure consisting exclusively of carbon nanotubes serving as bone regeneration scaffold and as bone defect filler

http://hdl.handle.net/10091/00020975
http://hdl.handle.net/10091/00020975
d7b3e066-3e47-44b3-a4e7-61c486e00096
名前 / ファイル ライセンス アクション
journal.pone.0172601.pdf journal.pone.0172601.pdf (3.1 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2018-10-31
タイトル
タイトル A three-dimensional block structure consisting exclusively of carbon nanotubes serving as bone regeneration scaffold and as bone defect filler
言語
言語 eng
DOI
関連識別子 https://doi.org/10.1371/journal.pone.0172601
関連名称 10.1371/journal.pone.0172601
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Tanaka, Manabu

× Tanaka, Manabu

en Tanaka, Manabu

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Sato, Yoshinori

× Sato, Yoshinori

en Sato, Yoshinori

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Haniu, Hisao

× Haniu, Hisao

en Haniu, Hisao

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Nomura, Hiroki

× Nomura, Hiroki

en Nomura, Hiroki

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Kobayashi, Shinsuke

× Kobayashi, Shinsuke

en Kobayashi, Shinsuke

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Takanashi, Seiji

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en Takanashi, Seiji

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Okamoto, Masanori

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en Okamoto, Masanori

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Takizawa, Takashi

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en Takizawa, Takashi

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Aoki, Kaoru

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en Aoki, Kaoru

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Usui, Yuki

× Usui, Yuki

en Usui, Yuki

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Oishi, Ayumu

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en Oishi, Ayumu

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Kato, Hiroyuki

× Kato, Hiroyuki

en Kato, Hiroyuki

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Saito, Naoto

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en Saito, Naoto

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信州大学研究者総覧へのリンク
氏名 Haniu, Hisao
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.jakpPmSa.html
信州大学研究者総覧へのリンク
氏名 Okamoto, Masanori
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.uafabVym.html
信州大学研究者総覧へのリンク
氏名 Aoki, Kaoru
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.WeDpbhym.html
信州大学研究者総覧へのリンク
氏名 Kato, Hiroyuki
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.WVkCbaSp.html
信州大学研究者総覧へのリンク
氏名 Saito, Naoto
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.WpkhuUkh.html
出版者
出版者 PUBLIC LIBRARY SCIENCE
引用
内容記述 PLOS ONE.12(2):e0172601(2017)
書誌情報 PLOS ONE

巻 12, 号 2, p. e0172601, 発行日 2017-02-24
抄録
内容記述 Many recent studies have been conducted to assess the ability of composite materials containing carbon nanotubes (CNTs) with high bone affinity to serve as scaffolds in bone regenerative medicine. These studies have demonstrated that CNTs can effectively induce bone formation. However, no studies have investigated the usefulness of scaffolds consisting exclusively of CNTs in bone regenerative medicine. We built a three-dimensional block entity with maximized mechanical strength from multi-walled CNTs (MWCNT blocks) and evaluated their efficacy as scaffold material for bone repair. When MWCNT blocks containing recombinant human bone morphogenetic protein-2 (rhBMP-2) were implanted in mouse muscle, ectopic bone was formed in direct contact with the blocks. Their bone marrow densities were comparable to those of PET-reinforced collagen sheets with rhBMP-2. On day 1 and day 3, MC3T3-E1 preosteoblasts were attached to the scaffold surface of MWCNT blocks than that of PET-reinforced collagen sheets. They also showed a maximum compression strength comparable to that of cortical bone. Our MWCNT blocks are expected to serve as bone defect filler and scaffold material for bone regeneration.
資源タイプ(コンテンツの種類)
ISSN
収録物識別子タイプ PISSN
収録物識別子 1932-6203
PubMed
識別子タイプ PMID
関連識別子 https://www.ncbi.nlm.nih.gov/pubmed/28235026
関連名称 28235026
権利
権利情報 © 2017 Tanaka et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
WoS
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000394688200098
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Cite as

Tanaka, Manabu, Sato, Yoshinori, Haniu, Hisao, Nomura, Hiroki, Kobayashi, Shinsuke, Takanashi, Seiji, Okamoto, Masanori, Takizawa, Takashi, Aoki, Kaoru, Usui, Yuki, Oishi, Ayumu, Kato, Hiroyuki, Saito, Naoto, 2017, A three-dimensional block structure consisting exclusively of carbon nanotubes serving as bone regeneration scaffold and as bone defect filler: PUBLIC LIBRARY SCIENCE, e0172601– p.

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