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  1. 050 医学部, 大学院医学系研究科
  2. 0501 学術論文

The Dispersion State of Tangled Multi-Walled Carbon Nanotubes Affects Their Cytotoxicity

http://hdl.handle.net/10091/00020976
http://hdl.handle.net/10091/00020976
82b15309-15a1-459a-8a31-2cbab08dc6ab
名前 / ファイル ライセンス アクション
nanomaterials-06-00219.pdf nanomaterials-06-00219.pdf (1.5 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2018-10-31
タイトル
タイトル The Dispersion State of Tangled Multi-Walled Carbon Nanotubes Affects Their Cytotoxicity
言語
言語 eng
DOI
関連識別子 https://doi.org/10.3390/nano6110219
関連名称 10.3390/nano6110219
キーワード
主題 multi-walled carbon nanotube, tangle, sonicator, cytotoxicity, AlamarBlue assay
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Kuroda, Chika

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en Kuroda, Chika

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Haniu, Hisao

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en Haniu, Hisao

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Ajima, Kumiko

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en Ajima, Kumiko

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Tanaka, Manabu

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en Tanaka, Manabu

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Sobajima, Atsushi

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en Sobajima, Atsushi

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Ishida, Haruka

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Tsukahara, Tamotsu

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Matsuda, Yoshikazu

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Aoki, Kaoru

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Kato, Hiroyuki

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Saito, Naoto

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信州大学研究者総覧へのリンク
氏名 Haniu, Hisao
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.jakpPmSa.html
信州大学研究者総覧へのリンク
氏名 Aoki, Kaoru
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.WeDpbhym.html
信州大学研究者総覧へのリンク
氏名 Kato, Hiroyuki
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.WVkCbaSp.html
信州大学研究者総覧へのリンク
氏名 Saito, Naoto
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.WpkhuUkh.html
出版者
出版者 MDPI AG
引用
内容記述 NANOMATERIALS.6(11):219(2016)
書誌情報 NANOMATERIALS

巻 6, 号 11, p. 219, 発行日 2016-11-19
抄録
内容記述 The medical applications of carbon nanotubes (CNTs) have garnered much attention. However, evaluating the safety of CNTs remains difficult, and no consensus has been reached. Moreover, assessing the biosafety of multi-walled CNTs (MWCNTs), which can become tangled during manufacturing, is challenging because they do not readily disperse. We studied how the dispersion state of tangled MWCNTs affects their cytotoxicity, using three sonicators. Flotube 9110 (FT9110), tangled MWCNTs, were dispersed in two dispersants (fetal bovine serum and polysorbate 80) using a new type of sonicator (PR-1) and two conventional sonicators. The size and cytotoxicity of the dispersed FT9110 were measured using the BEAS-2B human bronchial epithelial cell line. The PR-1 dispersed the FT9110 to agglomerates <200 nm in diameter; FT9110 dispersed with the PR-1 did not show cytotoxicity regardless of dispersant. The other sonicators dispersed the FT9110 to particles >1000 nm in diameter, and cytotoxicity depended on the dispersant. We found that excluding cells adhered to agglomerated FT9110 before evaluating cytotoxicity can lead to false-positive results. The PR-1 sonicator dispersed tangled FT9110 to many single fibers, which showed lower cytotoxicity than conventionally-sonicated MWCNTs. We suggest that dispersion state should be accounted for when evaluating the cytotoxicity of MWCNTs.
資源タイプ(コンテンツの種類)
ISSN
収録物識別子タイプ PISSN
収録物識別子 2079-4991
PubMed
識別子タイプ PMID
関連識別子 https://www.ncbi.nlm.nih.gov/pubmed/28335347
関連名称 28335347
権利
権利情報 © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
WoS
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000390103400029
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