| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2018-10-31 |
| タイトル |
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タイトル |
Aging-related anatomical and biochemical changes in lymphatic collectors impair lymph transport, fluid homeostasis, and pathogen clearance |
| 言語 |
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言語 |
eng |
| DOI |
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関連識別子 |
https://doi.org/10.1111/acel.12330 |
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関連名称 |
10.1111/acel.12330 |
| 資源タイプ |
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資源 |
http://purl.org/coar/resource_type/c_6501 |
|
タイプ |
journal article |
| 著者 |
Zolla, Valerio
Nizamutdinova, Irina Tsoy
Scharf, Brian
Clement, Cristina C.
Maejima, Daisuke
Akl, Tony
Nagai, Takashi
Luciani, Paola
Leroux, Jean-Christophe
Halin, Cornelia
Stukes, Sabriya
Tiwari, Sangeeta
Casadevall, Arturo
Jacobs, William R. Jr.
Entenberg, David
Zawieja, David C.
Condeelis, John
Fooksman, David R.
Gashev, Anatoliy A.
Santambrogio, Laura
|
| 信州大学研究者総覧へのリンク |
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氏名 |
Maejima, Daisuke |
|
URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.uFyNOhyC.html |
| 出版者 |
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出版者 |
WILEY-BLACKWELL |
| 引用 |
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内容記述 |
AGING CELL.14(4):582-594(2015) |
| 書誌情報 |
AGING CELL
巻 14,
号 4,
p. 582-594,
発行日 2015-05-15
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| 抄録 |
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内容記述 |
The role of lymphatic vessels is to transport fluid, soluble molecules, and immune cells to the draining lymph nodes. Here, we analyze how the aging process affects the functionality of the lymphatic collectors and the dynamics of lymph flow. Ultrastructural, biochemical, and proteomic analysis indicates a loss of matrix proteins, and smooth muscle cells in aged collectors resulting in a decrease in contraction frequency, systolic lymph flow velocity, and pumping activity, as measured in vivo in lymphatic collectors. Functionally, this impairment also translated into a reduced ability for in vivo bacterial transport as determined by time‐lapse microscopy. Ultrastructural and proteomic analysis also indicates a decrease in the thickness of the endothelial cell glycocalyx and loss of gap junction proteins in aged lymph collectors. Redox proteomic analysis mapped an aging‐related increase in the glycation and carboxylation of lymphatic's endothelial cell and matrix proteins. Functionally, these modifications translate into apparent hyperpermeability of the lymphatics with pathogen escaping from the collectors into the surrounding tissue and a decreased ability to control tissue fluid homeostasis. Altogether, our data provide a mechanistic analysis of how the anatomical and biochemical changes, occurring in aged lymphatic vessels, compromise lymph flow, tissue fluid homeostasis, and pathogen transport. |
| 資源タイプ（コンテンツの種類） |
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| ISSN |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
1474-9718 |
| 書誌レコードID |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AA1168790X |
| PubMed |
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識別子タイプ |
PMID |
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関連識別子 |
https://www.ncbi.nlm.nih.gov/pubmed/25982749 |
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関連名称 |
25982749 |
| 権利 |
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権利情報 |
© 2015 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| 出版タイプ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| WoS |
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|
URL |
http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000357941900008 |
Zolla_et_al-2015-Aging_Cell.pdf (2.7 MB)
