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  1. 050 医学部, 大学院医学系研究科
  2. 0501 学術論文

Aging-related anatomical and biochemical changes in lymphatic collectors impair lymph transport, fluid homeostasis, and pathogen clearance

http://hdl.handle.net/10091/00020977
http://hdl.handle.net/10091/00020977
15dfd6cf-a6e5-486e-8286-1f6bde7c6d8b
名前 / ファイル ライセンス アクション
Zolla_et_al-2015-Aging_Cell.pdf Zolla_et_al-2015-Aging_Cell.pdf (2.7 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2018-10-31
タイトル
言語 en
タイトル Aging-related anatomical and biochemical changes in lymphatic collectors impair lymph transport, fluid homeostasis, and pathogen clearance
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Zolla, Valerio

× Zolla, Valerio

WEKO 106597

en Zolla, Valerio

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Nizamutdinova, Irina Tsoy

× Nizamutdinova, Irina Tsoy

WEKO 106598

en Nizamutdinova, Irina Tsoy

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Scharf, Brian

× Scharf, Brian

WEKO 106599

en Scharf, Brian

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Clement, Cristina C.

× Clement, Cristina C.

WEKO 106600

en Clement, Cristina C.

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Maejima, Daisuke

× Maejima, Daisuke

WEKO 106601

en Maejima, Daisuke

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Akl, Tony

× Akl, Tony

WEKO 106602

en Akl, Tony

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Nagai, Takashi

× Nagai, Takashi

WEKO 106603

en Nagai, Takashi

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Luciani, Paola

× Luciani, Paola

WEKO 106604

en Luciani, Paola

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Leroux, Jean-Christophe

× Leroux, Jean-Christophe

WEKO 106605

en Leroux, Jean-Christophe

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Halin, Cornelia

× Halin, Cornelia

WEKO 106606

en Halin, Cornelia

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Stukes, Sabriya

× Stukes, Sabriya

WEKO 106607

en Stukes, Sabriya

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Tiwari, Sangeeta

× Tiwari, Sangeeta

WEKO 106608

en Tiwari, Sangeeta

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Casadevall, Arturo

× Casadevall, Arturo

WEKO 106609

en Casadevall, Arturo

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Jacobs, William R. Jr.

× Jacobs, William R. Jr.

WEKO 106610

en Jacobs, William R. Jr.

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Entenberg, David

× Entenberg, David

WEKO 106611

en Entenberg, David

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Zawieja, David C.

× Zawieja, David C.

WEKO 106612

en Zawieja, David C.

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Condeelis, John

× Condeelis, John

WEKO 106613

en Condeelis, John

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Fooksman, David R.

× Fooksman, David R.

WEKO 106614

en Fooksman, David R.

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Gashev, Anatoliy A.

× Gashev, Anatoliy A.

WEKO 106615

en Gashev, Anatoliy A.

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Santambrogio, Laura

× Santambrogio, Laura

WEKO 106616

en Santambrogio, Laura

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信州大学研究者総覧へのリンク
氏名 Maejima, Daisuke
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.uFyNOhyC.html
出版者
出版者 WILEY-BLACKWELL
引用
内容記述タイプ Other
内容記述 AGING CELL.14(4):582-594(2015)
書誌情報 AGING CELL

巻 14, 号 4, p. 582-594, 発行日 2015-05-15
抄録
内容記述タイプ Abstract
内容記述 The role of lymphatic vessels is to transport fluid, soluble molecules, and immune cells to the draining lymph nodes. Here, we analyze how the aging process affects the functionality of the lymphatic collectors and the dynamics of lymph flow. Ultrastructural, biochemical, and proteomic analysis indicates a loss of matrix proteins, and smooth muscle cells in aged collectors resulting in a decrease in contraction frequency, systolic lymph flow velocity, and pumping activity, as measured in vivo in lymphatic collectors. Functionally, this impairment also translated into a reduced ability for in vivo bacterial transport as determined by time‐lapse microscopy. Ultrastructural and proteomic analysis also indicates a decrease in the thickness of the endothelial cell glycocalyx and loss of gap junction proteins in aged lymph collectors. Redox proteomic analysis mapped an aging‐related increase in the glycation and carboxylation of lymphatic's endothelial cell and matrix proteins. Functionally, these modifications translate into apparent hyperpermeability of the lymphatics with pathogen escaping from the collectors into the surrounding tissue and a decreased ability to control tissue fluid homeostasis. Altogether, our data provide a mechanistic analysis of how the anatomical and biochemical changes, occurring in aged lymphatic vessels, compromise lymph flow, tissue fluid homeostasis, and pathogen transport.
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Article
ISSN
収録物識別子タイプ PISSN
収録物識別子 1474-9718
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA1168790X
PubMed
識別子タイプ PMID
関連識別子 https://www.ncbi.nlm.nih.gov/pubmed/25982749
関連名称 25982749
DOI
識別子タイプ DOI
関連識別子 https://doi.org/10.1111/acel.12330
関連名称 10.1111/acel.12330
権利
権利情報 © 2015 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
WoS
表示名 Web of Science
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000357941900008
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