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Eyelid Opening with Trigeminal Proprioceptive Activation Regulates a Brainstem Arousal Mechanism
http://hdl.handle.net/10091/00020979
http://hdl.handle.net/10091/000209797b41386d-0e1c-4af3-91a2-b08c8f733860
| 名前 / ファイル | ライセンス | アクション |
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journal.pone.0134659.PDF (5.0 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||
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| 公開日 | 2018-10-31 | |||||||||||||
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| タイトル | Eyelid Opening with Trigeminal Proprioceptive Activation Regulates a Brainstem Arousal Mechanism | |||||||||||||
| 言語 | ||||||||||||||
| 言語 | eng | |||||||||||||
| DOI | ||||||||||||||
| 関連識別子 | https://doi.org/10.1371/journal.pone.0134659 | |||||||||||||
| 関連名称 | 10.1371/journal.pone.0134659 | |||||||||||||
| 資源タイプ | ||||||||||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||
| タイプ | journal article | |||||||||||||
| 著者 |
Matsuo, Kiyoshi
× Matsuo, Kiyoshi
× Ban, Ryokuya
× Hama, Yuki
× Yuzuriha, Shunsuke
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| 信州大学研究者総覧へのリンク | ||||||||||||||
| 氏名 | Yuzuriha, Shunsuke | |||||||||||||
| URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.gULNHhkh.html | |||||||||||||
| 出版者 | ||||||||||||||
| 出版者 | PUBLIC LIBRARY SCIENCE | |||||||||||||
| 引用 | ||||||||||||||
| 内容記述 | PLOS ONE.10(8): e0134659(2015) | |||||||||||||
| 書誌情報 |
PLOS ONE 巻 10, 号 8, p. e0134659, 発行日 2015-08-05 |
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| 抄録 | ||||||||||||||
| 内容記述 | Eyelid opening stretches mechanoreceptors in the supratarsal Müller muscle to activate the proprioceptive fiber supplied by the trigeminal mesencephalic nucleus. This proprioception induces reflex contractions of the slow-twitch fibers in the levator palpebrae superioris and frontalis muscles to sustain eyelid and eyebrow positions against gravity. The cell bodies of the trigeminal proprioceptive neurons in the mesencephalon potentially make gap-junctional connections with the locus coeruleus neurons. The locus coeruleus is implicated in arousal and autonomic function. Due to the relationship between arousal, ventromedial prefrontal cortex, and skin conductance, we assessed whether upgaze with trigeminal proprioceptive evocation activates sympathetically innervated sweat glands and the ventromedial prefrontal cortex. Specifically, we examined whether 60° upgaze induces palmar sweating and hemodynamic changes in the prefrontal cortex in 16 subjects. Sweating was monitored using a thumb-mounted perspiration meter, and prefrontal cortex activity was measured with 45-channel, functional near-infrared spectroscopy (fNIRS) and 2-channel NIRS at Fp1 and Fp2. In 16 subjects, palmar sweating was induced by upgaze and decreased in response to downgaze. Upgaze activated the ventromedial prefrontal cortex with an accumulation of integrated concentration changes in deoxyhemoglobin, oxyhemoglobin, and total hemoglobin levels in 12 subjects. Upgaze phasically and degree-dependently increased deoxyhemoglobin level at Fp1 and Fp2, whereas downgaze phasically decreased it in 16 subjects. Unilateral anesthetization of mechanoreceptors in the supratarsal Müller muscle used to significantly reduce trigeminal proprioceptive evocation ipsilaterally impaired the increased deoxyhemoglobin level by 60° upgaze at Fp1 or Fp2 in 6 subjects. We concluded that upgaze with strong trigeminal proprioceptive evocation was sufficient to phasically activate sympathetically innervated sweat glands and appeared to induce rapid oxygen consumption in the ventromedial prefrontal cortex and to rapidly produce deoxyhemoglobin to regulate physiological arousal. Thus, eyelid opening with trigeminal proprioceptive evocation may activate the ventromedial prefrontal cortex via the mesencephalic trigeminal nucleus and locus coeruleus. | |||||||||||||
| 資源タイプ（コンテンツの種類） | ||||||||||||||
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| 収録物識別子タイプ | PISSN | |||||||||||||
| 収録物識別子 | 1932-6203 | |||||||||||||
| PubMed | ||||||||||||||
| 識別子タイプ | PMID | |||||||||||||
| 関連識別子 | https://www.ncbi.nlm.nih.gov/pubmed/26244675 | |||||||||||||
| 関連名称 | 26244675 | |||||||||||||
| 権利 | ||||||||||||||
| 権利情報 | © 2015 Matsuo et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited | |||||||||||||
| 出版タイプ | ||||||||||||||
| 出版タイプ | VoR | |||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||
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| URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000359061400097 | |||||||||||||
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Matsuo, Kiyoshi, Ban, Ryokuya, Hama, Yuki, Yuzuriha, Shunsuke, 2015, Eyelid Opening with Trigeminal Proprioceptive Activation Regulates a Brainstem Arousal Mechanism: PUBLIC LIBRARY SCIENCE, e0134659– p.
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