{"_buckets": {"deposit": "83fcaaec-9fe7-4416-b692-80a375b688bd"}, "_deposit": {"id": "20235", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "20235"}, "status": "published"}, "_oai": {"id": "oai:soar-ir.repo.nii.ac.jp:00020235", "sets": ["462"]}, "author_link": ["106729", "106730", "106731", "106732", "106733", "106734", "106735", "106736", "106737", "106738", "106739", "106740"], "item_1628147817048": {"attribute_name": "出版タイプ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_ab4af688f83e57aa", "subitem_version_type": "AM"}]}, "item_6_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2016-11-17", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "6", "bibliographicPageEnd": "905", "bibliographicPageStart": "897", "bibliographicVolumeNumber": "37", "bibliographic_titles": [{"bibliographic_title": "LIVER INTERNATIONAL"}]}]}, "item_6_description_20": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Background \u0026 Aims\u003cbr/\u003ePrimary biliary cholangitis (PBC) is an autoimmune liver disease characterized by portal inflammation and immune‐mediated destruction of intrahepatic bile ducts that often leads to liver decompensation and liver failure. Although the biochemical response to ursodeoxycholic acid (UDCA) can predict disease outcome in PBC, few biomarkers have been identified as prognostic tools applicable prior to UDCA treatment. We therefore sought to identify such indicators of long‐term outcome in PBC in the Japanese population.\u003cbr/\u003eMethods\u003cbr/\u003eThe prebiopsy serum samples and subsequent clinical data of 136 patients with PBC treated with UDCA were analysed over a median follow‐up period of 8.8 years. Serum levels of biomarkers related to microbial translocation (sCD14, EndoCAb and I‐FABP) were measured along with those of 33 cytokines and chemokines and additional auto‐antibodies. Associations between the tested parameters and the clinical outcomes of liver decompensation and liver‐related death/liver transplantation were evaluated using the Cox proportional hazards model with stepwise methods and Kaplan‐Meier analysis.\u003cbr/\u003eResults\u003cbr/\u003eElevated levels of serum IL‐8, and sCD14 before UDCA therapy were significantly associated with both liver decompensation and liver‐related death/liver transplantation. In multivariate analyses, IL‐8≥46.5 pg/mL or sCD14≥2.0 μg/mL at enrolment demonstrated the same results. Kaplan‐Meier analysis also revealed IL‐8 and sCD14 to be significantly associated with a poor outcome. sCD14 was significantly correlated with IL‐8. EndoCAb and I‐FABP were not related to disease outcome.\u003cbr/\u003eConclusions\u003cbr/\u003eSerum IL‐8 and sCD14 levels before UDCA therapy represent noninvasive surrogate markers of prognosis in patients with PBC.", "subitem_description_type": "Abstract"}]}, "item_6_description_30": {"attribute_name": "資源タイプ（コンテンツの種類）", "attribute_value_mlt": [{"subitem_description": "Article", "subitem_description_type": "Other"}]}, "item_6_description_5": {"attribute_name": "引用", "attribute_value_mlt": [{"subitem_description": "LIVER INTERNATIONAL.37(6):897-905(2016)", "subitem_description_type": "Other"}]}, "item_6_link_3": {"attribute_name": "信州大学研究者総覧へのリンク", "attribute_value_mlt": [{"subitem_link_text": "Umemura, Takeji", "subitem_link_url": "http://soar-rd.shinshu-u.ac.jp/profile/ja.ymSpgpkh.html"}]}, "item_6_link_67": {"attribute_name": "WoS", "attribute_value_mlt": [{"subitem_link_text": "Web of Science", "subitem_link_url": "http://gateway.isiknowledge.com/gateway/Gateway.cgi?\u0026GWVersion=2\u0026SrcAuth=ShinshuUniv\u0026SrcApp=ShinshuUniv\u0026DestLinkType=FullRecord\u0026DestApp=WOS\u0026KeyUT=000403921100017"}]}, "item_6_publisher_4": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "WILEY"}]}, "item_6_relation_47": {"attribute_name": "PubMed", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "27860118"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://www.ncbi.nlm.nih.gov/pubmed/27860118", "subitem_relation_type_select": "PMID"}}]}, "item_6_relation_48": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "10.1111/liv.13316"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1111/liv.13316", "subitem_relation_type_select": "DOI"}}]}, "item_6_rights_62": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "This is the peer reviewed version of the following article: [Umemura, Takeji. et al. \"Association between serum soluble CD14 and IL‐8 levels and clinical outcome in primary biliary cholangitis\". LIVER INTERNATIONAL.37(6):897-905(2016)], which has been published in final form at [https://doi.org/10.1111/liv.13316]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions."}]}, "item_6_select_64": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "author"}]}, "item_6_source_id_35": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1478-3223", "subitem_source_identifier_type": "PISSN"}]}, "item_6_source_id_39": {"attribute_name": "NII ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1478-3223", "subitem_source_identifier_type": "PISSN"}]}, "item_6_source_id_40": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AA11817539", "subitem_source_identifier_type": "NCID"}]}, "item_6_text_69": {"attribute_name": "wosonly authkey", "attribute_value_mlt": [{"subitem_text_value": "decompensation; liver-related death; microbial translocation; primary biliary cholangitis; transplantation"}]}, "item_6_text_70": {"attribute_name": "wosonly keywords", "attribute_value_mlt": [{"subitem_text_value": "FATTY LIVER-DISEASE; CHRONIC HEPATITIS-C; BIOCHEMICAL RESPONSE; URSODEOXYCHOLIC ACID; PEGYLATED INTERFERON; GENE POLYMORPHISMS; RIBAVIRIN THERAPY; JAPANESE PATIENTS; EPITHELIAL-CELLS; GUT MICROBIOTA"}]}, "item_6_textarea_68": {"attribute_name": "wosonly abstract", "attribute_value_mlt": [{"subitem_textarea_value": "Background \u0026 Aims: Primary biliary cholangitis (PBC) is an autoimmune liver disease characterized by portal inflammation and immune-mediated destruction of intrahepatic bile ducts that often leads to liver decompensation and liver failure. Although the biochemical response to ursodeoxycholic acid (UDCA) can predict disease outcome in PBC, few biomarkers have been identified as prognostic tools applicable prior to UDCA treatment. We therefore sought to identify such indicators of long-term outcome in PBC in the Japanese population. \u003cbr/\u003eMethods: The prebiopsy serum samples and subsequent clinical data of 136 patients with PBC treated with UDCA were analysed over a median follow-up period of 8.8 years. Serum levels of biomarkers related to microbial translocation (sCD14, EndoCAb and I-FABP) were measured along with those of 33 cytokines and chemokines and additional auto-antibodies. Associations between the tested parameters and the clinical outcomes of liver decompensation and liver-related death/liver transplantation were evaluated using the Cox proportional hazards model with stepwise methods and Kaplan-Meier analysis. \u003cbr/\u003eResults: Elevated levels of serum IL-8, and sCD14 before UDCA therapy were significantly associated with both liver decompensation and liver-related death/liver transplantation. In multivariate analyses, IL-8 \u003e= 46.5 pg/mL or sCD14 \u003e= 2.0 mu g/mL at enrolment demonstrated the same results. Kaplan-Meier analysis also revealed IL-8 and sCD14 to be significantly associated with a poor outcome. sCD14 was significantly correlated with IL-8. EndoCAb and I-FABP were not related to disease outcome. \u003cbr/\u003eConclusions: Serum IL-8 and sCD14 levels before UDCA therapy represent noninvasive surrogate markers of prognosis in patients with PBC."}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Umemura, Takeji", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "106729", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sekiguchi, Tomohiro", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "106730", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Joshita, Satoru", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "106731", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yamazaki, Tomoo", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "106732", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Shibata, Soichiro", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "106733", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ichikawa, Yuki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "106734", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Komatsu, Michiharu", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "106735", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Matsumoto, Akihiro", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "106736", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Shums, Zakera", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "106737", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Norman, Gary L.", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "106738", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tanaka, Eiji", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "106739", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ota, Masao", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "106740", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-10-31"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "LIVint-16-00824R1.pdf", "filesize": [{"value": "238.3 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensefree": "This is the peer reviewed version of the following article: [Umemura, Takeji. et al. \"Association between serum soluble CD14 and IL‐8 levels and clinical outcome in primary biliary cholangitis\". 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