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Association between serum soluble CD14 and IL-8 levels and clinical outcome in primary biliary cholangitis
http://hdl.handle.net/10091/00020993
http://hdl.handle.net/10091/00020993a8a9aae3-4baa-4632-b12f-a144bc3c60e9
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
LIVint-16-00824R1.pdf (238.3 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-10-31 | |||||
| タイトル | ||||||
| タイトル | Association between serum soluble CD14 and IL-8 levels and clinical outcome in primary biliary cholangitis | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1111/liv.13316 | |||||
| 関連名称 | 10.1111/liv.13316 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | decompensation | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | liver‐related death | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | microbial translocation | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | primary biliary cholangitis | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | transplantation | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Umemura, Takeji
× Umemura, Takeji× Sekiguchi, Tomohiro× Joshita, Satoru× Yamazaki, Tomoo× Shibata, Soichiro× Ichikawa, Yuki× Komatsu, Michiharu× Matsumoto, Akihiro× Shums, Zakera× Norman, Gary L.× Tanaka, Eiji× Ota, Masao |
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| 信州大学研究者総覧へのリンク | ||||||
| 表示名 | Umemura, Takeji | |||||
| URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.ymSpgpkh.html | |||||
| 出版者 | ||||||
| 出版者 | WILEY | |||||
| 引用 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | LIVER INTERNATIONAL.37(6):897-905(2016) | |||||
| 書誌情報 |
LIVER INTERNATIONAL 巻 37, 号 6, p. 897-905, 発行日 2016-11-17 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Background & Aims<br/>Primary biliary cholangitis (PBC) is an autoimmune liver disease characterized by portal inflammation and immune‐mediated destruction of intrahepatic bile ducts that often leads to liver decompensation and liver failure. Although the biochemical response to ursodeoxycholic acid (UDCA) can predict disease outcome in PBC, few biomarkers have been identified as prognostic tools applicable prior to UDCA treatment. We therefore sought to identify such indicators of long‐term outcome in PBC in the Japanese population.<br/>Methods<br/>The prebiopsy serum samples and subsequent clinical data of 136 patients with PBC treated with UDCA were analysed over a median follow‐up period of 8.8 years. Serum levels of biomarkers related to microbial translocation (sCD14, EndoCAb and I‐FABP) were measured along with those of 33 cytokines and chemokines and additional auto‐antibodies. Associations between the tested parameters and the clinical outcomes of liver decompensation and liver‐related death/liver transplantation were evaluated using the Cox proportional hazards model with stepwise methods and Kaplan‐Meier analysis.<br/>Results<br/>Elevated levels of serum IL‐8, and sCD14 before UDCA therapy were significantly associated with both liver decompensation and liver‐related death/liver transplantation. In multivariate analyses, IL‐8≥46.5 pg/mL or sCD14≥2.0 μg/mL at enrolment demonstrated the same results. Kaplan‐Meier analysis also revealed IL‐8 and sCD14 to be significantly associated with a poor outcome. sCD14 was significantly correlated with IL‐8. EndoCAb and I‐FABP were not related to disease outcome.<br/>Conclusions<br/>Serum IL‐8 and sCD14 levels before UDCA therapy represent noninvasive surrogate markers of prognosis in patients with PBC. | |||||
| 資源タイプ（コンテンツの種類） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Article | |||||
| ISSN | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 1478-3223 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA11817539 | |||||
| PubMed | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | https://www.ncbi.nlm.nih.gov/pubmed/27860118 | |||||
| 関連名称 | 27860118 | |||||
| 権利 | ||||||
| 権利情報 | This is the peer reviewed version of the following article: [Umemura, Takeji. et al. "Association between serum soluble CD14 and IL‐8 levels and clinical outcome in primary biliary cholangitis". LIVER INTERNATIONAL.37(6):897-905(2016)], which has been published in final form at [https://doi.org/10.1111/liv.13316]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. | |||||
| 出版タイプ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| WoS | ||||||
| 表示名 | Web of Science | |||||
| URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000403921100017 | |||||
