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Polyhydramnios in Lrp4 knockout mice with bilateral kidney agenesis: Defects in the pathways of amniotic fluid clearance
http://hdl.handle.net/10091/00020999
http://hdl.handle.net/10091/00020999846a6a3f-e9eb-405b-aeaa-887d41f7ee0e
| 名前 / ファイル | ライセンス | アクション |
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srep20241.pdf (1.5 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||||||
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| 公開日 | 2018-10-31 | |||||||||||||||||
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| タイトル | Polyhydramnios in Lrp4 knockout mice with bilateral kidney agenesis: Defects in the pathways of amniotic fluid clearance | |||||||||||||||||
| 言語 | ||||||||||||||||||
| 言語 | eng | |||||||||||||||||
| DOI | ||||||||||||||||||
| 関連識別子 | https://doi.org/10.1038/srep20241 | |||||||||||||||||
| 関連名称 | 10.1038/srep20241 | |||||||||||||||||
| 資源タイプ | ||||||||||||||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||
| タイプ | journal article | |||||||||||||||||
| 著者 |
Tanahashi, Hiroshi
× Tanahashi, Hiroshi
× Tian, Qing-Bao
× Hara, Yoshinobu
× Sakagami, Hiroyuki
× Endo, Shogo
× Suzuki, Tatsuo
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| 出版者 | ||||||||||||||||||
| 出版者 | NATURE PUBLISHING GROUP | |||||||||||||||||
| 引用 | ||||||||||||||||||
| 内容記述 | SCIENTIFIC REPORTS.6:20241(2016) | |||||||||||||||||
| 書誌情報 |
SCIENTIFIC REPORTS 巻 6, p. 20241, 発行日 2016-02-05 |
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| 抄録 | ||||||||||||||||||
| 内容記述 | Amniotic fluid volume during mid-to-late gestation depends mainly on the urine excretion from the foetal kidneys and partly on the fluid secretion from the foetal lungs during foetal breathing-like movements. Urine is necessary for foetal breathing-like movements, which is critical for foetal lung development. Bilateral renal agenesis and/or obstruction of the urinary tract lead to oligohydramnios, which causes infant death within a short period after birth due to pulmonary hypoplasia. Lrp4, which functions as an agrin receptor, is essential for the formation of neuromuscular junctions. Herein, we report novel phenotypes of Lrp4 knockout (Lrp4−/−) mice. Most Lrp4−/− foetuses showed unilateral or bilateral kidney agenesis, and Lrp4 knockout resulted in polyhydramnios. The loss of Lrp4 compromised foetal swallowing and breathing-like movements and downregulated the expression of aquaporin-9 in the foetal membrane and aquaporin-1 in the placenta, which possibly affected the amniotic fluid clearance. These results suggest that amniotic fluid removal was compromised in Lrp4−/− foetuses, resulting in polyhydramnios despite the impairment of urine production. Our findings indicate that amniotic fluid removal plays an essential role in regulating the amniotic fluid volume. | |||||||||||||||||
| 資源タイプ（コンテンツの種類） | ||||||||||||||||||
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| 収録物識別子タイプ | PISSN | |||||||||||||||||
| 収録物識別子 | 2045-2322 | |||||||||||||||||
| PubMed | ||||||||||||||||||
| 識別子タイプ | PMID | |||||||||||||||||
| 関連識別子 | https://www.ncbi.nlm.nih.gov/pubmed/26847765 | |||||||||||||||||
| 関連名称 | 26847765 | |||||||||||||||||
| 権利 | ||||||||||||||||||
| 権利情報 | This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ | |||||||||||||||||
| 出版タイプ | ||||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||
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| URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000369384900001 | |||||||||||||||||
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Tanahashi, Hiroshi, Tian, Qing-Bao, Hara, Yoshinobu, Sakagami, Hiroyuki, Endo, Shogo, Suzuki, Tatsuo, 2016, Polyhydramnios in Lrp4 knockout mice with bilateral kidney agenesis: Defects in the pathways of amniotic fluid clearance: NATURE PUBLISHING GROUP, 20241– p.
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