{"_buckets": {"deposit": "d4034698-a86e-46fc-8b02-7a6f2a10bbb0"}, "_deposit": {"id": "20243", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "20243"}, "status": "published"}, "_oai": {"id": "oai:soar-ir.repo.nii.ac.jp:00020243", "sets": ["462"]}, "author_link": ["106786", "106787", "106788", "106789", "106790", "106791", "106792", "106793", "106794", "106795", "106796", "106797", "106798", "106799", "106800", "106801", "106802"], "item_1628147817048": {"attribute_name": "出版タイプ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_6_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2016-09-02", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "9", "bibliographicPageStart": "e0162400", "bibliographicVolumeNumber": "11", "bibliographic_titles": [{"bibliographic_title": "PLOS ONE"}]}]}, "item_6_description_20": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Background\u003cbr/\u003eThe high recurrence rate after surgery for colorectal cancer liver metastasis (CLM) remains a crucial problem. The aim of this trial was to evaluate the efficacy of adjuvant therapy with uracil-tegafur and leucovorin (UFT/LV).\u003cbr/\u003eMethods\u003cbr/\u003eIn the multicenter, open-label, phase III trial, patients undergoing curative resection of CLM were randomly assigned in a 1:1 ratio to either the UFT/LV group or surgery alone group. The UFT/LV group orally received 5 cycles of adjuvant UFT/LV (UFT 300mg/m2 and LV 75mg/day for 28 days followed by a 7-day rest per cycle). The primary endpoint was recurrence-free survival (RFS). Secondary endpoints included overall survival (OS).\u003cbr/\u003eResults\u003cbr/\u003eBetween February 2004 and December 2010, 180 patients (90 in each group) were enrolled into the study. Of these, 3 patients (2 in the UFT/LV group and 1 in the surgery alone group) were excluded from the efficacy analysis. Median follow-up was 4.76 (range, 0.15–9.84) years. The RFS rate at 3 years was higher in the UFT/LV group (38.6%, n = 88) than in the surgery alone group (32.3%, n = 89). The median RFS in the UFT/LV and surgery alone groups were 1.45 years and 0.70 years, respectively. UFT/LV significantly prolonged the RFS compared with surgery alone with the hazard ratio of 0.56 (95% confidence interval, 0.38–0.83; P = 0.003). The hazard ratio for death of the UFT/LV group against the surgery alone group was not significant (0.80; 95% confidence interval, 0.48–1.35; P = 0.409).\u003cbr/\u003eConclusion\u003cbr/\u003eAdjuvant therapy with UFT/LV effectively prolongs RFS after hepatic resection for CLM and can be recommended as an alternative choice.", "subitem_description_type": "Abstract"}]}, "item_6_description_30": {"attribute_name": "資源タイプ（コンテンツの種類）", "attribute_value_mlt": [{"subitem_description": "Article", "subitem_description_type": "Other"}]}, "item_6_description_5": {"attribute_name": "引用", "attribute_value_mlt": [{"subitem_description": "PLOS ONE.11(9):e0162400(2016)", "subitem_description_type": "Other"}]}, "item_6_link_67": {"attribute_name": "WoS", "attribute_value_mlt": [{"subitem_link_text": "Web of Science", "subitem_link_url": "http://gateway.isiknowledge.com/gateway/Gateway.cgi?\u0026GWVersion=2\u0026SrcAuth=ShinshuUniv\u0026SrcApp=ShinshuUniv\u0026DestLinkType=FullRecord\u0026DestApp=WOS\u0026KeyUT=000382877800055"}]}, "item_6_publisher_4": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "PUBLIC LIBRARY SCIENCE"}]}, "item_6_relation_47": {"attribute_name": "PubMed", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "27588959"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://www.ncbi.nlm.nih.gov/pubmed/27588959", "subitem_relation_type_select": "PMID"}}]}, "item_6_relation_48": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "10.1371/journal.pone.0162400"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1371/journal.pone.0162400", "subitem_relation_type_select": "DOI"}}]}, "item_6_rights_62": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "© 2016 Hasegawa et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited."}]}, "item_6_select_64": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_6_source_id_35": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1932-6203", "subitem_source_identifier_type": "PISSN"}]}, "item_6_source_id_39": {"attribute_name": "NII ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1932-6203", "subitem_source_identifier_type": "PISSN"}]}, "item_6_text_70": {"attribute_name": "wosonly keywords", "attribute_value_mlt": [{"subitem_text_value": "III COLON-CANCER; INTRAVENOUS FLUOROURACIL; PHASE-III; STAGE-II; HEPATIC RESECTION; PLUS LEUCOVORIN; FOLINIC ACID; NSABP C-07; CHEMOTHERAPY; SURGERY"}]}, "item_6_textarea_68": {"attribute_name": "wosonly abstract", "attribute_value_mlt": [{"subitem_textarea_value": "Background \u003cbr/\u003eThe high recurrence rate after surgery for colorectal cancer liver metastasis (CLM) remains a crucial problem. The aim of this trial was to evaluate the efficacy of adjuvant therapy with uracil-tegafur and leucovorin (UFT/LV). \u003cbr/\u003eMethods \u003cbr/\u003eIn the multicenter, open-label, phase III trial, patients undergoing curative resection of CLM were randomly assigned in a 1:1 ratio to either the UFT/LV group or surgery alone group. The UFT/LV group orally received 5 cycles of adjuvant UFT/LV (UFT 300mg/m(2) and LV 75mg/day for 28 days followed by a 7-day rest per cycle). The primary endpoint was recurrence-free survival (RFS). Secondary endpoints included overall survival (OS). \u003cbr/\u003eResults \u003cbr/\u003eBetween February 2004 and December 2010, 180 patients (90 in each group) were enrolled into the study. Of these, 3 patients (2 in the UFT/LV group and 1 in the surgery alone group) were excluded from the efficacy analysis. Median follow-up was 4.76 (range, 0.15-9.84) years. The RFS rate at 3 years was higher in the UFT/LV group (38.6%, n = 88) than in the surgery alone group (32.3%, n = 89). The median RFS in the UFT/LV and surgery alone groups were 1.45 years and 0.70 years, respectively. UFT/LV significantly prolonged the RFS compared with surgery alone with the hazard ratio of 0.56 (95% confidence interval, 0.38-0.83; P = 0.003). The hazard ratio for death of the UFT/LV group against the surgery alone group was not significant (0.80; 95% confidence interval, 0.48-1.35; P = 0.409). \u003cbr/\u003eConclusion \u003cbr/\u003eAdjuvant therapy with UFT/LV effectively prolongs RFS after hepatic resection for CLM and can be recommended as an alternative choice."}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Hasegawa, Kiyoshi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "106786", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Saiura, Akio", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "106787", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Takayama, Tadatoshi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "106788", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Miyagawa, Shinichi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "106789", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yamamoto, Junji", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "106790", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ijichi, Masayoshi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "106791", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Teruya, Masanori", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "106792", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yoshimi, Fuyo", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "106793", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kawasaki, Seiji", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "106794", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Koyama, Hiroto", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "106795", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Oba, Masaru", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "106796", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Takahashi, Michiro", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "106797", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Mizunuma, Nobuyuki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "106798", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Matsuyama, Yutaka", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "106799", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Watanabe, Toshiaki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "106800", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Makuuchi, Masatoshi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "106801", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kokudo, Norihiro", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "106802", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-10-31"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "journal.pone.0162400.PDF", "filesize": [{"value": "3.0 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensefree": "© 2016 Hasegawa et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.", "licensetype": "license_note", "mimetype": "application/pdf", "size": 3000000.0, "url": {"label": "journal.pone.0162400.PDF", "url": "https://soar-ir.repo.nii.ac.jp/record/20243/files/journal.pone.0162400.PDF"}, "version_id": "580faed4-f486-475a-b3c1-bbcdc7b63522"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Adjuvant Oral Uracil-Tegafur with Leucovorin for Colorectal Cancer Liver Metastases: A Randomized Controlled Trial", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Adjuvant Oral Uracil-Tegafur with Leucovorin for Colorectal Cancer Liver Metastases: A Randomized Controlled Trial", "subitem_title_language": "en"}]}, "item_type_id": "6", "owner": "1", "path": ["462"], "permalink_uri": "http://hdl.handle.net/10091/00021001", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2018-10-31"}, "publish_date": "2018-10-31", "publish_status": "0", "recid": "20243", "relation": {}, "relation_version_is_last": true, "title": ["Adjuvant Oral Uracil-Tegafur with Leucovorin for Colorectal Cancer Liver Metastases: A Randomized Controlled Trial"], "weko_shared_id": -1}