WEKO3
-
RootNode
アイテム
Adjuvant Oral Uracil-Tegafur with Leucovorin for Colorectal Cancer Liver Metastases: A Randomized Controlled Trial
http://hdl.handle.net/10091/00021001
http://hdl.handle.net/10091/00021001bcb6746c-4a96-412d-8b60-1a83e41a6bf0
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
journal.pone.0162400.PDF (3.0 MB)
|
|
| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2018-10-31 | |||||||||||||||||||||||||||||||||||||||
| タイトル | ||||||||||||||||||||||||||||||||||||||||
| タイトル | Adjuvant Oral Uracil-Tegafur with Leucovorin for Colorectal Cancer Liver Metastases: A Randomized Controlled Trial | |||||||||||||||||||||||||||||||||||||||
| 言語 | ||||||||||||||||||||||||||||||||||||||||
| 言語 | eng | |||||||||||||||||||||||||||||||||||||||
| DOI | ||||||||||||||||||||||||||||||||||||||||
| 関連識別子 | https://doi.org/10.1371/journal.pone.0162400 | |||||||||||||||||||||||||||||||||||||||
| 関連名称 | 10.1371/journal.pone.0162400 | |||||||||||||||||||||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||||||||||||||||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||||||||||||||||||||
| タイプ | journal article | |||||||||||||||||||||||||||||||||||||||
| 著者 |
Hasegawa, Kiyoshi
× Hasegawa, Kiyoshi
× Saiura, Akio
× Takayama, Tadatoshi
× Miyagawa, Shinichi
× Yamamoto, Junji
× Ijichi, Masayoshi
× Teruya, Masanori
× Yoshimi, Fuyo
× Kawasaki, Seiji
× Koyama, Hiroto
× Oba, Masaru
× Takahashi, Michiro
× Mizunuma, Nobuyuki
× Matsuyama, Yutaka
× Watanabe, Toshiaki
× Makuuchi, Masatoshi
× Kokudo, Norihiro
|
|||||||||||||||||||||||||||||||||||||||
| 出版者 | ||||||||||||||||||||||||||||||||||||||||
| 出版者 | PUBLIC LIBRARY SCIENCE | |||||||||||||||||||||||||||||||||||||||
| 引用 | ||||||||||||||||||||||||||||||||||||||||
| 内容記述 | PLOS ONE.11(9):e0162400(2016) | |||||||||||||||||||||||||||||||||||||||
| 書誌情報 |
PLOS ONE 巻 11, 号 9, p. e0162400, 発行日 2016-09-02 |
|||||||||||||||||||||||||||||||||||||||
| 抄録 | ||||||||||||||||||||||||||||||||||||||||
| 内容記述 | Background<br/>The high recurrence rate after surgery for colorectal cancer liver metastasis (CLM) remains a crucial problem. The aim of this trial was to evaluate the efficacy of adjuvant therapy with uracil-tegafur and leucovorin (UFT/LV).<br/>Methods<br/>In the multicenter, open-label, phase III trial, patients undergoing curative resection of CLM were randomly assigned in a 1:1 ratio to either the UFT/LV group or surgery alone group. The UFT/LV group orally received 5 cycles of adjuvant UFT/LV (UFT 300mg/m2 and LV 75mg/day for 28 days followed by a 7-day rest per cycle). The primary endpoint was recurrence-free survival (RFS). Secondary endpoints included overall survival (OS).<br/>Results<br/>Between February 2004 and December 2010, 180 patients (90 in each group) were enrolled into the study. Of these, 3 patients (2 in the UFT/LV group and 1 in the surgery alone group) were excluded from the efficacy analysis. Median follow-up was 4.76 (range, 0.15–9.84) years. The RFS rate at 3 years was higher in the UFT/LV group (38.6%, n = 88) than in the surgery alone group (32.3%, n = 89). The median RFS in the UFT/LV and surgery alone groups were 1.45 years and 0.70 years, respectively. UFT/LV significantly prolonged the RFS compared with surgery alone with the hazard ratio of 0.56 (95% confidence interval, 0.38–0.83; P = 0.003). The hazard ratio for death of the UFT/LV group against the surgery alone group was not significant (0.80; 95% confidence interval, 0.48–1.35; P = 0.409).<br/>Conclusion<br/>Adjuvant therapy with UFT/LV effectively prolongs RFS after hepatic resection for CLM and can be recommended as an alternative choice. | |||||||||||||||||||||||||||||||||||||||
| 資源タイプ（コンテンツの種類） | ||||||||||||||||||||||||||||||||||||||||
| ISSN | ||||||||||||||||||||||||||||||||||||||||
| 収録物識別子タイプ | PISSN | |||||||||||||||||||||||||||||||||||||||
| 収録物識別子 | 1932-6203 | |||||||||||||||||||||||||||||||||||||||
| PubMed | ||||||||||||||||||||||||||||||||||||||||
| 識別子タイプ | PMID | |||||||||||||||||||||||||||||||||||||||
| 関連識別子 | https://www.ncbi.nlm.nih.gov/pubmed/27588959 | |||||||||||||||||||||||||||||||||||||||
| 関連名称 | 27588959 | |||||||||||||||||||||||||||||||||||||||
| 権利 | ||||||||||||||||||||||||||||||||||||||||
| 権利情報 | © 2016 Hasegawa et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | |||||||||||||||||||||||||||||||||||||||
| 出版タイプ | ||||||||||||||||||||||||||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||||||||||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||||||||||||||||||||||||
| WoS | ||||||||||||||||||||||||||||||||||||||||
| URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000382877800055 | |||||||||||||||||||||||||||||||||||||||
Share
Cite as
Hasegawa, Kiyoshi, Saiura, Akio, Takayama, Tadatoshi, Miyagawa, Shinichi, Yamamoto, Junji, Ijichi, Masayoshi, Teruya, Masanori, Yoshimi, Fuyo, Kawasaki, Seiji, Koyama, Hiroto, Oba, Masaru, Takahashi, Michiro, Mizunuma, Nobuyuki, Matsuyama, Yutaka, Watanabe, Toshiaki, Makuuchi, Masatoshi, Kokudo, Norihiro, 2016, Adjuvant Oral Uracil-Tegafur with Leucovorin for Colorectal Cancer Liver Metastases: A Randomized Controlled Trial: PUBLIC LIBRARY SCIENCE, e0162400– p.
Loading...
