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  1. 050 医学部, 大学院医学系研究科 (Faculty&Graduate School of Medicine)
  2. 0501 学術論文 (Journal Articles)

Ablation of the N-type calcium channel ameliorates diabetic nephropathy with improved glycemic control and reduced blood pressure

http://hdl.handle.net/10091/00021006
c594f1e2-0d48-4c79-8d22-af2d10bfde36
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srep27192.pdf srep27192.pdf (2.7 MB)
This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
item type 学術雑誌論文 / Journal Article(1)
公開日 2018-10-31
タイトル
タイトル Ablation of the N-type calcium channel ameliorates diabetic nephropathy with improved glycemic control and reduced blood pressure
言語
言語 eng
キーワード
主題 Diabetic nephropathy
キーワード
主題 Hypertension
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Ohno, Shoko

× Ohno, Shoko

WEKO 106879

Ohno, Shoko

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Yokoi, Hideki

× Yokoi, Hideki

WEKO 106880

Yokoi, Hideki

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Mori, Kiyoshi

× Mori, Kiyoshi

WEKO 106881

Mori, Kiyoshi

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Kasahara, Masato

× Kasahara, Masato

WEKO 106882

Kasahara, Masato

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Kuwahara, Koichiro

× Kuwahara, Koichiro

WEKO 106883

Kuwahara, Koichiro

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Fujikura, Junji

× Fujikura, Junji

WEKO 106884

Fujikura, Junji

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Naito, Masaki

× Naito, Masaki

WEKO 106885

Naito, Masaki

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Kuwabara, Takashige

× Kuwabara, Takashige

WEKO 106886

Kuwabara, Takashige

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Imamaki, Hirotaka

× Imamaki, Hirotaka

WEKO 106887

Imamaki, Hirotaka

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Ishii, Akira

× Ishii, Akira

WEKO 106888

Ishii, Akira

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Saleem, Moin A.

× Saleem, Moin A.

WEKO 106889

Saleem, Moin A.

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Numata, Tomohiro

× Numata, Tomohiro

WEKO 106890

Numata, Tomohiro

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Mori, Yasuo

× Mori, Yasuo

WEKO 106891

Mori, Yasuo

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Nakao, Kazuwa

× Nakao, Kazuwa

WEKO 106892

Nakao, Kazuwa

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Yanagita, Motoko

× Yanagita, Motoko

WEKO 106893

Yanagita, Motoko

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Mukoyama, Masashi

× Mukoyama, Masashi

WEKO 106894

Mukoyama, Masashi

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信州大学研究者総覧へのリンク
Kuwahara, Koichiro
http://soar-rd.shinshu-u.ac.jp/profile/ja.HVchWCcp.html
出版者
出版者 NATURE PUBLISHING GROUP
引用
内容記述タイプ Other
内容記述 SCIENTIFIC REPORTS. 6: 27192(2016)
書誌情報 SCIENTIFIC REPORTS

巻 6, p. 27192, 発行日 2016-06-07
抄録
内容記述タイプ Abstract
内容記述 Pharmacological blockade of the N- and L-type calcium channel lessens renal injury in kidney disease patients. The significance of specific blockade of α1 subunit of N-type calcium channel, Cav2.2, in diabetic nephropathy, however, remains to be clarified. To examine functional roles, we mated Cav2.2−/− mice with db/db (diabetic) mice on the C57BLKS background. Cav2.2 was localized in glomeruli including podocytes and in distal tubular cells. Diabetic Cav2.2−/− mice significantly reduced urinary albumin excretion, glomerular hyperfiltration, blood glucose levels, histological deterioration and systolic blood pressure (SBP) with decreased urinary catecholamine compared to diabetic Cav2.2+/+ mice. Interestingly, diabetic heterozygous Cav2.2+/− mice also decreased albuminuria, although they exhibited comparable systolic blood pressure, sympathetic nerve activity and creatinine clearance to diabetic Cav2.2+/+ mice. Consistently, diabetic mice with cilnidipine, an N-/L-type calcium channel blocker, showed a reduction in albuminuria and improvement of glomerular changes compared to diabetic mice with nitrendipine. In cultured podocytes, depolarization-dependent calcium responses were decreased by ω-conotoxin, a Cav2.2-specific inhibitor. Furthermore, reduction of nephrin by transforming growth factor-β (TGF-β) in podocytes was abolished with ω-conotoxin, cilnidipine or mitogen-activated protein kinase kinase inhibitor. In conclusion, Cav2.2 inhibition exerts renoprotective effects against the progression of diabetic nephropathy, partly by protecting podocytes.
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Article
ISSN
収録物識別子タイプ ISSN
収録物識別子 2045-2322
PubMed
関連識別子
識別子タイプ PMID
関連識別子 https://www.ncbi.nlm.nih.gov/pubmed/27273361
関連名称
関連名称 27273361
DOI
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1038/srep27192
関連名称
関連名称 10.1038/srep27192
権利
権利情報 This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
著者版フラグ
値 publisher
WoS
Web of Science
http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000377663900001
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