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IL1RAPL1 knockout mice show spine density decrease, learning deficiency, hyperactivity and reduced anxiety-like behaviours
http://hdl.handle.net/10091/00021013
http://hdl.handle.net/10091/00021013f901fde4-9747-41cb-af0d-011210492d4b
| 名前 / ファイル | ライセンス | アクション |
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srep06613.pdf (3.3 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||||||||||||||||||
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| 公開日 | 2018-10-31 | |||||||||||||||||||||||||||||
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| タイトル | IL1RAPL1 knockout mice show spine density decrease, learning deficiency, hyperactivity and reduced anxiety-like behaviours | |||||||||||||||||||||||||||||
| 言語 | ||||||||||||||||||||||||||||||
| 言語 | eng | |||||||||||||||||||||||||||||
| DOI | ||||||||||||||||||||||||||||||
| 関連識別子 | https://doi.org/10.1038/srep06613 | |||||||||||||||||||||||||||||
| 関連名称 | 10.1038/srep06613 | |||||||||||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||||||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||||||||||
| タイプ | journal article | |||||||||||||||||||||||||||||
| 著者 |
Yasumura, Misato
× Yasumura, Misato
× Yoshida, Tomoyuki
× Yamazaki, Maya
× Abe, Manabu
× Natsume, Rie
× Kanno, Kouta
× Uemura, Takeshi
× Takao, Keizo
× Sakimura, Kenji
× Kikusui, Takefumi
× Miyakawa, Tsuyoshi
× Mishina, Masayoshi
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| 信州大学研究者総覧へのリンク | ||||||||||||||||||||||||||||||
| 氏名 | Uemura, Takeshi | |||||||||||||||||||||||||||||
| URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.HmANWayV.html | |||||||||||||||||||||||||||||
| 出版者 | ||||||||||||||||||||||||||||||
| 出版者 | NATURE PUBLISHING GROUP | |||||||||||||||||||||||||||||
| 引用 | ||||||||||||||||||||||||||||||
| 内容記述 | SCIENTIFIC REPORTS.4:6613(2014) | |||||||||||||||||||||||||||||
| 書誌情報 |
SCIENTIFIC REPORTS 巻 4, p. 6613, 発行日 2014-10-14 |
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| 抄録 | ||||||||||||||||||||||||||||||
| 内容記述 | IL-1 receptor accessory protein-like 1 (IL1RAPL1) is responsible for nonsyndromic intellectual disability and is associated with autism. IL1RAPL1 mediates excitatory synapse formation through trans-synaptic interaction with PTPδ. Here, we showed that the spine density of cortical neurons was significantly reduced in IL1RAPL1 knockout mice. The spatial reference and working memories and remote fear memory were mildly impaired in IL1RAPL1 knockout mice. Furthermore, the behavioural flexibility was slightly reduced in the T-maze test. Interestingly, the performance of IL1RAPL1 knockout mice in the rotarod test was significantly better than that of wild-type mice. Moreover, IL1RAPL1 knockout mice consistently exhibited high locomotor activity in all the tasks examined. In addition, open-space and height anxiety-like behaviours were decreased in IL1RAPL1 knockout mice. These results suggest that IL1RAPL1 ablation resulted in spine density decrease and affected not only learning but also behavioural flexibility, locomotor activity and anxiety. | |||||||||||||||||||||||||||||
| 資源タイプ（コンテンツの種類） | ||||||||||||||||||||||||||||||
| ISSN | ||||||||||||||||||||||||||||||
| 収録物識別子タイプ | EISSN | |||||||||||||||||||||||||||||
| 収録物識別子 | 2045-2322 | |||||||||||||||||||||||||||||
| PubMed | ||||||||||||||||||||||||||||||
| 識別子タイプ | PMID | |||||||||||||||||||||||||||||
| 関連識別子 | https://www.ncbi.nlm.nih.gov/pubmed/25312502 | |||||||||||||||||||||||||||||
| 関連名称 | 25312502 | |||||||||||||||||||||||||||||
| 権利 | ||||||||||||||||||||||||||||||
| 権利情報 | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder in order to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||||||||||||||||||||||||||
| 出版タイプ | ||||||||||||||||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||||||||||||||
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| URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000343086000001 | |||||||||||||||||||||||||||||
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Yasumura, Misato, Yoshida, Tomoyuki, Yamazaki, Maya, Abe, Manabu, Natsume, Rie, Kanno, Kouta, Uemura, Takeshi, Takao, Keizo, Sakimura, Kenji, Kikusui, Takefumi, Miyakawa, Tsuyoshi, Mishina, Masayoshi, 2014, IL1RAPL1 knockout mice show spine density decrease, learning deficiency, hyperactivity and reduced anxiety-like behaviours: NATURE PUBLISHING GROUP, 6613– p.
