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  1. 050 医学部, 大学院医学系研究科
  2. 0501 学術論文

IL1RAPL1 knockout mice show spine density decrease, learning deficiency, hyperactivity and reduced anxiety-like behaviours

http://hdl.handle.net/10091/00021013
http://hdl.handle.net/10091/00021013
f901fde4-9747-41cb-af0d-011210492d4b
名前 / ファイル ライセンス アクション
srep06613.pdf srep06613.pdf (3.3 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2018-10-31
タイトル
タイトル IL1RAPL1 knockout mice show spine density decrease, learning deficiency, hyperactivity and reduced anxiety-like behaviours
言語
言語 eng
DOI
関連識別子 https://doi.org/10.1038/srep06613
関連名称 10.1038/srep06613
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Yasumura, Misato

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Yoshida, Tomoyuki

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en Yoshida, Tomoyuki

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Yamazaki, Maya

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Abe, Manabu

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en Abe, Manabu

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Natsume, Rie

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Kanno, Kouta

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en Kanno, Kouta

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Uemura, Takeshi

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en Uemura, Takeshi

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Takao, Keizo

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Sakimura, Kenji

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Kikusui, Takefumi

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Miyakawa, Tsuyoshi

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Mishina, Masayoshi

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en Mishina, Masayoshi

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信州大学研究者総覧へのリンク
氏名 Uemura, Takeshi
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.HmANWayV.html
出版者
出版者 NATURE PUBLISHING GROUP
引用
内容記述 SCIENTIFIC REPORTS.4:6613(2014)
書誌情報 SCIENTIFIC REPORTS

巻 4, p. 6613, 発行日 2014-10-14
抄録
内容記述 IL-1 receptor accessory protein-like 1 (IL1RAPL1) is responsible for nonsyndromic intellectual disability and is associated with autism. IL1RAPL1 mediates excitatory synapse formation through trans-synaptic interaction with PTPδ. Here, we showed that the spine density of cortical neurons was significantly reduced in IL1RAPL1 knockout mice. The spatial reference and working memories and remote fear memory were mildly impaired in IL1RAPL1 knockout mice. Furthermore, the behavioural flexibility was slightly reduced in the T-maze test. Interestingly, the performance of IL1RAPL1 knockout mice in the rotarod test was significantly better than that of wild-type mice. Moreover, IL1RAPL1 knockout mice consistently exhibited high locomotor activity in all the tasks examined. In addition, open-space and height anxiety-like behaviours were decreased in IL1RAPL1 knockout mice. These results suggest that IL1RAPL1 ablation resulted in spine density decrease and affected not only learning but also behavioural flexibility, locomotor activity and anxiety.
資源タイプ(コンテンツの種類)
ISSN
収録物識別子タイプ EISSN
収録物識別子 2045-2322
PubMed
識別子タイプ PMID
関連識別子 https://www.ncbi.nlm.nih.gov/pubmed/25312502
関連名称 25312502
権利
権利情報 This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder in order to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
WoS
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000343086000001
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Cite as

Yasumura, Misato, Yoshida, Tomoyuki, Yamazaki, Maya, Abe, Manabu, Natsume, Rie, Kanno, Kouta, Uemura, Takeshi, Takao, Keizo, Sakimura, Kenji, Kikusui, Takefumi, Miyakawa, Tsuyoshi, Mishina, Masayoshi, 2014, IL1RAPL1 knockout mice show spine density decrease, learning deficiency, hyperactivity and reduced anxiety-like behaviours: NATURE PUBLISHING GROUP, 6613– p.

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