Item type |
学術雑誌論文 / Journal Article(1) |
公開日 |
2018-10-31 |
タイトル |
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タイトル |
Striatal dopamine D1 receptor is essential for contextual fear conditioning |
言語 |
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言語 |
eng |
DOI |
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関連識別子 |
https://doi.org/10.1038/srep03976 |
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関連名称 |
10.1038/srep03976 |
資源タイプ |
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資源 |
http://purl.org/coar/resource_type/c_6501 |
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タイプ |
journal article |
著者 |
Ikegami, Masaru
Uemura, Takeshi
Kishioka, Ayumi
Sakimura, Kenji
Mishina, Masayoshi
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信州大学研究者総覧へのリンク |
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氏名 |
Uemura, Takeshi |
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URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.HmANWayV.html |
出版者 |
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出版者 |
NATURE PUBLISHING GROUP |
引用 |
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内容記述 |
SCIENTIFIC REPORTS.4:3976(2014) |
書誌情報 |
SCIENTIFIC REPORTS
巻 4,
p. 3976,
発行日 2014-02-05
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抄録 |
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内容記述 |
Fear memory is critical for animals to trigger behavioural adaptive responses to potentially threatening stimuli, while too much or inappropriate fear may cause psychiatric problems. Numerous studies have shown that the amygdala, hippocampus and medial prefrontal cortex play important roles in Pavlovian fear conditioning. Recently, we showed that striatal neurons are required for the formation of the auditory fear memory when the unconditioned stimulus is weak. Here, we found that selective ablation of striatal neurons strongly diminished contextual fear conditioning irrespective of the intensity of footshock. Furthermore, contextual fear conditioning was strongly reduced in striatum-specific dopamine D1 receptor knockout mice. On the other hand, striatum-specific dopamine D2 receptor knockout mice showed freezing responses comparable to those of control mice. These results suggest that striatal D1 receptor is essential for contextual fear conditioning. |
資源タイプ(コンテンツの種類) |
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内容記述 |
Article |
ISSN |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
2045-2322 |
PubMed |
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関連識別子 |
https://www.ncbi.nlm.nih.gov/pubmed/24496082 |
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関連名称 |
24496082 |
権利 |
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権利情報 |
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareALike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/ |
出版タイプ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
WoS |
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URL |
http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000331221300003 |