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Consolidation of auditory fear memories formed by weak unconditioned stimuli requires NMDA receptor activation and de novo protein synthesis in the striatum
http://hdl.handle.net/10091/00021015
http://hdl.handle.net/10091/0002101587dd9e12-e565-42f4-9c3a-364e7d23230e
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
1756-6606-6-17.pdf (2.4 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2018-10-31 | |||||
| タイトル | ||||||
| タイトル | Consolidation of auditory fear memories formed by weak unconditioned stimuli requires NMDA receptor activation and de novo protein synthesis in the striatum | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1186/1756-6606-6-17 | |||||
| 関連名称 | 10.1186/1756-6606-6-17 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Memory | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Striatum | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Auditory fear conditioning | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | NMDA receptor | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Protein synthesis | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Kishioka, Ayumi
× Kishioka, Ayumi× Uemura, Takeshi× Fukushima, Fumiaki× Mishina, Masayoshi |
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| 信州大学研究者総覧へのリンク | ||||||
| 表示名 | Uemura, Takeshi | |||||
| URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.HmANWayV.html | |||||
| 出版者 | ||||||
| 出版者 | BIOMED CENTRAL LTD | |||||
| 引用 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | MOLECULAR BRAIN.6:17(2013) | |||||
| 書誌情報 |
MOLECULAR BRAIN 巻 6, p. 17, 発行日 2013-04-15 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Background Fear is one of the most potent emotional experiences and is an adaptive component of response to potentially threatening stimuli. Cumulative evidence suggests that the amygdala plays a central role in the acquisition, storage and expression of fear memory. We previously showed that the selective ablation of striatal neurons in the adult brain impairs the long-term, but not short-term, memory for auditory fear conditioning with a lower-intensity footshock. This finding raises an intriguing possibility that long-term auditory fear memory may be consolidated in the striatum. Results There was a significant difference in the freezing responses between two groups of mice subjected to paired and unpaired conditioning, indicating that the auditory fear conditioning with a lower-intensity footshock is an associative learning. Post-conditioning infusion of NMDA receptor inhibitors into the striatum suppressed the consolidation of auditory fear memory when mice were conditioned with a low-intensity footshock. Furthermore, intra-striatum infusion of protein synthesis blocker anisomycin immediately or 1?h after the conditioning prevented the formation of auditory fear memory. On the other hand, the infusion of anisomycin 3?h after conditioning exerted little effect on the auditory fear conditioning, consistent with the presence of a critical time window of protein synthesis for memory consolidation. Conclusions These results suggest that NMDA receptors and de novo protein synthesis in the striatum are crucial for the consolidation of auditory fear memory formed with a low-intensity unconditioned stimulus. | |||||
| 資源タイプ（コンテンツの種類） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Article | |||||
| ISSN | ||||||
| 収録物識別子タイプ | EISSN | |||||
| 収録物識別子 | 1756-6606 | |||||
| PubMed | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | https://www.ncbi.nlm.nih.gov/pubmed/23587405 | |||||
| 関連名称 | 23587405 | |||||
| 権利 | ||||||
| 権利情報 | © Kishioka et al.; licensee BioMed Central Ltd. 2013This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | |||||
| 出版タイプ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| WoS | ||||||
| 表示名 | Web of Science | |||||
| URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000318913700001 | |||||
