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Spinal hemisection in rats, which has been developed as an animal model of spinal cord injury in humans, results in hyperexcitation of spinal dorsal horn neurons soon after the hemisection and thereafter. The hyperexcitation is likely caused by permanent elimination of the descending pain systems. We examined the change in synaptic transmission of substantia gelatinosa neurons following acute spinal hemisection by using an in vivo whole-cell patch-clamp technique. Results An increased spontaneous action potential firings of substantia gelatinosa neurons was detected in hemisected rats compared with that in control animals. The frequencies and amplitudes of spontaneous excitatory postsynaptic currents and of evoked excitatory postsynaptic currentss in response to non-noxious and noxious stimuli were not different between hemisected and control animals. 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The proportion of multi-receptive substantia gelatinosa neurons, which exhibit action potential firing in response to non-noxious and noxious stimuli, was much larger in hemisected animals than in control animals. Conclusions These suggest that substantia gelatinosa neurons receive tonic inhibition by spinal inhibitory interneurons which generate persistent action potentials. 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Spinal hemisection in rats, which has been developed as an animal model of spinal cord injury in humans, results in hyperexcitation of spinal dorsal horn neurons soon after the hemisection and thereafter. The hyperexcitation is likely caused by permanent elimination of the descending pain systems. We examined the change in synaptic transmission of substantia gelatinosa neurons following acute spinal hemisection by using an in vivo whole-cell patch-clamp technique.  Results: An increased spontaneous action potential firings of substantia gelatinosa neurons was detected in hemisected rats compared with that in control animals. The frequencies and amplitudes of spontaneous excitatory postsynaptic currents and of evoked excitatory postsynaptic currentss in response to non-noxious and noxious stimuli were not different between hemisected and control animals. 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  1. 050 医学部, 大学院医学系研究科
  2. 0501 学術論文

Changes in synaptic transmission of substantia gelatinosa neurons after spinal cord hemisection revealed by analysis using in vivo patch-clamp recording

http://hdl.handle.net/10091/00021016
http://hdl.handle.net/10091/00021016
3104f1c8-9216-4320-97f9-d0990abbcb22
名前 / ファイル ライセンス アクション
1744806916665827.pdf 1744806916665827.pdf (643.3 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2018-10-31
タイトル
言語 en
タイトル Changes in synaptic transmission of substantia gelatinosa neurons after spinal cord hemisection revealed by analysis using in vivo patch-clamp recording
言語
言語 eng
キーワード
主題Scheme Other
主題 Substantia gelatinosa
キーワード
主題Scheme Other
主題 spinal cord injury
キーワード
主題Scheme Other
主題 hemisection
キーワード
主題Scheme Other
主題 inhibitory postsynaptic currents
キーワード
主題Scheme Other
主題 excitatory postsynaptic currents
キーワード
主題Scheme Other
主題 in vivo
キーワード
主題Scheme Other
主題 patch-clamp
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Kozuka, Yuji

× Kozuka, Yuji

WEKO 106989

en Kozuka, Yuji

Search repository
Kawamata, Mikito

× Kawamata, Mikito

WEKO 106990

en Kawamata, Mikito

Search repository
Furue, Hidemasa

× Furue, Hidemasa

WEKO 106991

en Furue, Hidemasa

Search repository
Ishida, Takashi

× Ishida, Takashi

WEKO 106992

en Ishida, Takashi

Search repository
Tanaka, Satoshi

× Tanaka, Satoshi

WEKO 106993

en Tanaka, Satoshi

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Namiki, Akiyoshi

× Namiki, Akiyoshi

WEKO 106994

en Namiki, Akiyoshi

Search repository
Yamakage, Michiaki

× Yamakage, Michiaki

WEKO 106995

en Yamakage, Michiaki

Search repository
信州大学研究者総覧へのリンク
氏名 Kawamata, Mikito
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.HUcpuNkh.html
出版者
出版者 SAGE PUBLICATIONS INC
引用
内容記述タイプ Other
内容記述 MOLECULAR PAIN.12:1744806916665820(2016)
書誌情報 MOLECULAR PAIN

巻 12, p. 1.74481E+15, 発行日 2016-08-28
抄録
内容記述タイプ Abstract
内容記述 Background After spinal cord injury, central neuropathic pain develops in the majority of spinal cord injury patients. Spinal hemisection in rats, which has been developed as an animal model of spinal cord injury in humans, results in hyperexcitation of spinal dorsal horn neurons soon after the hemisection and thereafter. The hyperexcitation is likely caused by permanent elimination of the descending pain systems. We examined the change in synaptic transmission of substantia gelatinosa neurons following acute spinal hemisection by using an in vivo whole-cell patch-clamp technique. Results An increased spontaneous action potential firings of substantia gelatinosa neurons was detected in hemisected rats compared with that in control animals. The frequencies and amplitudes of spontaneous excitatory postsynaptic currents and of evoked excitatory postsynaptic currentss in response to non-noxious and noxious stimuli were not different between hemisected and control animals. On the contrary, the amplitude and frequency of spontaneous inhibitory postsynaptic currents of substantia gelatinosa neurons in hemisected animals were significantly smaller and lower, respectively, than those in control animals (P?<?0.01). Large amplitude and high-frequency spontaneous inhibitory postsynaptic currents, which could not be elicited by mechanical stimuli, were seen in 44% of substantia gelatinosa neurons in control animals but only in 17% of substantia gelatinosa neurons in hemisected animals. In control animals, such large amplitude spontaneous inhibitory postsynaptic currents were suppressed by spinal application of tetrodotoxin (1??M). Cervical application of lidocaine (2%, 10??l) also inhibited such large amplitude of inhibitory postsynaptic currents. The proportion of multi-receptive substantia gelatinosa neurons, which exhibit action potential firing in response to non-noxious and noxious stimuli, was much larger in hemisected animals than in control animals. Conclusions These suggest that substantia gelatinosa neurons receive tonic inhibition by spinal inhibitory interneurons which generate persistent action potentials. Spinal hemisection results in hyperexcitation of substantia gelatinosa neurons at least in part by eliminating the tonic descending control of spinal inhibitory interneurons from supraspinal levels
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Article
ISSN
収録物識別子タイプ EISSN
収録物識別子 1744-8069
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA12051230
PubMed
識別子タイプ PMID
関連識別子 https://www.ncbi.nlm.nih.gov/pubmed/27573517
関連名称 27573517
DOI
識別子タイプ DOI
関連識別子 https://doi.org/10.1177/1744806916665827
関連名称 10.1177/1744806916665827
権利
権利情報 Creative Commons Non Commercial CC-BY-NC: This article is distributed under the terms of the Creative Commons AttributionNonCommercial 3.0 License (http://www.creativecommons.org/licenses/by-nc/3.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
WoS
表示名 Web of Science
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000386445300001
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