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  1. 050 医学部, 大学院医学系研究科
  2. 0501 学術論文

Circulating Tumour DNA for Monitoring Treatment Response to Anti-PD-1 Immunotherapy in Melanoma Patients

http://hdl.handle.net/10091/00021019
http://hdl.handle.net/10091/00021019
d03e00a7-b049-41b9-8cbe-634368b0e396
名前 / ファイル ライセンス アクション
26461687_06.pdf 26461687_06.pdf (3.0 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2018-11-05
タイトル
言語 en
タイトル Circulating Tumour DNA for Monitoring Treatment Response to Anti-PD-1 Immunotherapy in Melanoma Patients
言語
言語 eng
キーワード
主題Scheme Other
主題 melanoma
キーワード
主題Scheme Other
主題 circulating tumour DNA
キーワード
主題Scheme Other
主題 anti-programmed cell death-1 antibody
キーワード
主題Scheme Other
主題 BRAF
キーワード
主題Scheme Other
主題 NRAS
キーワード
主題Scheme Other
主題 droplet digital PCR
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Ashida, Atsuko

× Ashida, Atsuko

WEKO 107007

en Ashida, Atsuko

Search repository
Sakaizawa, Kaori

× Sakaizawa, Kaori

WEKO 107008

en Sakaizawa, Kaori

Search repository
Uhara, Hisashi

× Uhara, Hisashi

WEKO 107009

en Uhara, Hisashi

Search repository
Okuyama, Ryuhei

× Okuyama, Ryuhei

WEKO 107010

en Okuyama, Ryuhei

Search repository
信州大学研究者総覧へのリンク
氏名 Ashida, Atsuko
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.PCcebUym.html
出版者
出版者 ACTA DERMATO-VENEREOLOGICA
引用
内容記述タイプ Other
内容記述 ACTA DERMATO-VENEREOLOGICA. 97:1212-1218(2018)
書誌情報 ACTA DERMATO-VENEREOLOGICA

巻 97, 号 10, p. 1212-1218, 発行日 2017-11
抄録
内容記述タイプ Abstract
内容記述 Anti-programmed cell death-1 (anti-PD-1) antibody shows high therapeutic efficacy in patients with advanced melanoma. However, assessment of its therapeutic activity can be challenging because of tumour enlargement associated with intratumoural inflammation. Because circulating tumour DNA (ctDNA) correlates with tumour burden, we assessed the value of ctDNA levels as an indicator of tumour changes. Quantification of ctDNA (BRAFmutant or NRASmutant) levels by droplet digital PCR in 5 patients with BRAF or NRAS mutant melanoma during the treatment course showed dynamic changes corresponding to radiological and clinical alterations. In 3 cases in which the anti-PD-1 antibody was effective, ctDNA levels decreased within 2?4 weeks after treatment initiation. In 2 cases in which the anti-PD-1 antibody was ineffective, ctDNA levels did not decrease after treatment initiation. ctDNA could be a useful biomarker to predict early response to treatment in patients with advanced melanoma treated with anti-PD-1 immunotherapy.
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Article
ISSN
収録物識別子タイプ PISSN
収録物識別子 0001-5555
PubMed
識別子タイプ PMID
関連識別子 https://www.ncbi.nlm.nih.gov/pubmed/28681063
関連名称 28681063
DOI
識別子タイプ DOI
関連識別子 https://doi.org/10.2340/00015555-2748
関連名称 10.2340/00015555-2748
権利
権利情報 Journal Compilation © 2017 Acta Dermato-Venereologica. This is an open access article under the CC BY-NC license. www.medicaljournals.se/acta
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
WoS
表示名 Web of Science
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000419735400010
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