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  1. 050 医学部, 大学院医学系研究科
  2. 0501 学術論文

Deletion of Lrp4 increases the incidence of microphthalmia

http://hdl.handle.net/10091/00021036
3d485e75-bc57-4124-9ec3-e5b70827a7f0
名前 / ファイル ライセンス アクション
Manuscript Manuscript Tanahashi and SI_1811.pdf (2.6 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2018-11-16
タイトル
言語 en
タイトル Deletion of Lrp4 increases the incidence of microphthalmia
言語
言語 eng
キーワード
主題Scheme Other
主題 BMP
キーワード
主題Scheme Other
主題 Coloboma
キーワード
主題Scheme Other
主題 Fold
キーワード
主題Scheme Other
主題 Microphthalmia
キーワード
主題Scheme Other
主題 SHH
キーワード
主題Scheme Other
主題 WNT
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Tanahashi, Hiroshi

× Tanahashi, Hiroshi

WEKO 107084

en Tanahashi, Hiroshi

Search repository
Suzuki, Tatsuo

× Suzuki, Tatsuo

WEKO 107085

en Suzuki, Tatsuo

Search repository
出版者
出版者 Elsevier Inc.
引用
内容記述タイプ Other
内容記述 Biochemical and Biophysical Research Communications. 506(2018)
書誌情報 Biochemical and Biophysical Research Communications

巻 506, 号 3, p. 478-484, 発行日 2018-11-30
抄録
内容記述タイプ Abstract
内容記述 Microphthalmia is a malformation that reduces the size of the ocular globe. The etiologies of this anomaly are various, but the genetic background appears to have a predominant influence on its development through mutations of genes controlling ocular developmental processes. LRP4 is a type I single transmembrane protein that is essential for the formation of neuromuscular junctions. We created and experimented on homozygous Lrp4-deficient mice and found the microphthalmia phenotype in their eyes. The loss of Lrp4 resulted in an elevated incidence of microphthalmia and affected the mRNA expression of the members of bone morphogenetic protein, fibroblast growth factor, Sonic hedgehog, and WNT signaling pathways and of several pathogenic genes for microphthalmia. Moreover, the loss of Lrp4 enhanced the incidence of aberrant retinal folds, which appeared pleated and corrugated in the eyeball.
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Article
ISSN
収録物識別子タイプ PISSN
収録物識別子 0006-291X
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00564395
PubMed
関連識別子
識別子タイプ PMID
関連識別子 https://www.ncbi.nlm.nih.gov/pubmed/30352686
関連名称
関連名称 30352686
DOI
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1016/j.bbrc.2018.10.062
関連名称
関連名称 10.1016/j.bbrc.2018.10.062
権利
権利情報 © 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
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