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Peroxisome proliferator-activated receptor alpha (PPAR alpha) is a master regulator of hepatic lipid homeostasis. To examine the contribution of PPAR alpha to changes in liver phenotypes induced by TFA, two diets were used: a purified control diet and an isocaloric diet in which most of the soybean oil, a major source of FA in the diet, was replaced with TFA-rich shortening. The diets were fed to wild-type and Ppara-null mice for 2 months. Ppara-null mice fed a TFA-containing diet showed more severe hepatic steatosis and liver damage compared with similarly treated wild-type mice, as revealed by increased hepatic triglyceride (TG) contents and serum alanine aminotransferase activities. While the TFA-rich diet increased the hepatic expression of enzymes involved in de novo FA synthesis and decreased TG-hydrolyzing enzymes in both genotypes, the expression of FA-catabolizing enzymes was decreased in Ppara-null mice, resulting in more severe hepatosteatosis. 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  1. 050 医学部, 大学院医学系研究科
  2. 0507 学位論文
  3. 博士(医学)

PPARα protects against trans-fatty-acid-containing diet-induced steatohepatitis(PPARαはトランス脂肪酸含有食誘発性脂肪性肝炎に対し保護的に作用する)

http://hdl.handle.net/10091/00021477
f1ae13b7-0d0b-4cf2-9d5c-24dcce9d02d2
名前 / ファイル ライセンス アクション
14MH282C_yoshi.pdf 内容の要旨 (128.7 kB)
14MH282C_shinsa.pdf 審査結果の要旨 (118.4 kB)
14MH282C_ronbun.pdf 博士論文の全文 (727.1 kB)
license.icon
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2019-06-14
タイトル
言語 en
タイトル PPARα protects against trans-fatty-acid-containing diet-induced steatohepatitis(PPARαはトランス脂肪酸含有食誘発性脂肪性肝炎に対し保護的に作用する)
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_db06
タイプ doctoral thesis
著者 胡, 暁

× 胡, 暁

WEKO 108055

胡, 暁

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出版者
出版者 信州大学
引用
内容記述タイプ Other
内容記述 胡 暁. PPARα protects against trans-fatty-acid-containing diet-induced steatohepatitis(PPARαはトランス脂肪酸含有食誘発性脂肪性肝炎に対し保護的に作用する). 信州大学, 2018, 博士論文.
書誌情報
発行日 2018-09-30
学位授与番号
学位授与番号 13601甲第1136号
学位授与年月日
学位授与年月日 2018-09-30
学位名
学位名 博士(医学)
学位授与機関
学位授与機関名
学位授与機関名 信州大学(Shinshu university)
学位の区分
Doctoral
学位の分野
医学
学位の報告番号
甲第1136号
内容記述
内容記述タイプ Other
内容記述 雑誌に発表。JOURNAL OF NUTRITIONAL BIOCHEMISTRY. 39:77-85 (2017); doi:10.1016/j.jnutbio.2016.09.015.
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Thesis
PubMed
関連識別子
識別子タイプ PMID
関連識別子 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search&DB=pubmed&term=27816763
関連名称
関連名称 27816763
DOI
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1016/j.jnutbio.2016.09.015
関連名称
関連名称 10.1016/j.jnutbio.2016.09.015
権利
権利情報 © 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
出版タイプ
出版タイプ NA
出版タイプResource http://purl.org/coar/version/c_be7fb7dd8ff6fe43
WoS
Web of Science
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000389566200009
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