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PPAR\u03b1 protects against trans-fatty-acid-containing diet-induced steatohepatitis\uff08PPAR\u03b1\u306f\u30c8\u30e9\u30f3\u30b9\u8102\u80aa\u9178\u542b\u6709\u98df\u8a98\u767a\u6027\u8102\u80aa\u6027\u809d\u708e\u306b\u5bfe\u3057\u4fdd\u8b77\u7684\u306b\u4f5c\u7528\u3059\u308b\uff09. \u4fe1\u5dde\u5927\u5b66, 2018, \u535a\u58eb\u8ad6\u6587.", "subitem_description_type": "Other"}]}, "item_14_dissertation_number_7": {"attribute_name": "\u5b66\u4f4d\u6388\u4e0e\u756a\u53f7", "attribute_value_mlt": [{"subitem_dissertationnumber": "13601\u7532\u7b2c1136\u53f7"}]}, "item_14_link_74": {"attribute_name": "WoS", "attribute_value_mlt": [{"subitem_link_text": "Web of Science", "subitem_link_url": "http://gateway.isiknowledge.com/gateway/Gateway.cgi?\u0026GWVersion=2\u0026SrcAuth=ShinshuUniv\u0026SrcApp=ShinshuUniv\u0026DestLinkType=FullRecord\u0026DestApp=WOS\u0026KeyUT=000389566200009"}]}, "item_14_publisher_4": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "\u4fe1\u5dde\u5927\u5b66"}]}, "item_14_relation_54": {"attribute_name": "PubMed", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "27816763"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search\u0026DB=pubmed\u0026term=27816763", "subitem_relation_type_select": "PMID"}}]}, "item_14_relation_55": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "10.1016/j.jnutbio.2016.09.015"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1016/j.jnutbio.2016.09.015", "subitem_relation_type_select": "DOI"}}]}, "item_14_rights_69": {"attribute_name": "\u6a29\u5229", "attribute_value_mlt": [{"subitem_rights": "\u00a9 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/"}]}, "item_14_select_71": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "ETD"}]}, "item_14_text_11": {"attribute_name": "\u5b66\u4f4d\u306e\u533a\u5206", "attribute_value_mlt": [{"subitem_text_value": "Doctoral"}]}, "item_14_text_12": {"attribute_name": "\u5b66\u4f4d\u306e\u5206\u91ce", "attribute_value_mlt": [{"subitem_text_value": "\u533b\u5b66"}]}, "item_14_text_13": {"attribute_name": "\u5b66\u4f4d\u306e\u5831\u544a\u756a\u53f7", "attribute_value_mlt": [{"subitem_text_value": "\u7532\u7b2c1136\u53f7"}]}, "item_14_text_76": {"attribute_name": "wosonly authkey", "attribute_value_mlt": [{"subitem_text_value": "trans-Fatty acid; PPAR alpha; Nuclear factor-kappa B; Osteopontin; Toll-like receptor; Inflammasome"}]}, "item_14_text_77": {"attribute_name": "wosonly keywords", "attribute_value_mlt": [{"subitem_text_value": "CHOLINE-DEFICIENT DIET; NF-KAPPA-B; NONALCOHOLIC STEATOHEPATITIS; OXIDATIVE STRESS; LIVER-DISEASE; METABOLIC SYNDROME; CHOLESTEROL LEVELS; DOWN-REGULATION; MICE; OSTEOPONTIN"}]}, "item_14_textarea_75": {"attribute_name": "wosonly abstract", "attribute_value_mlt": [{"subitem_textarea_value": "Consumption of trans-fatty acids (TFA), unsaturated fatty acids (FA) containing trans double bonds, is a risk factor for metabolic syndrome and steatohepatitis. Peroxisome proliferator-activated receptor alpha (PPAR alpha) is a master regulator of hepatic lipid homeostasis. To examine the contribution of PPAR alpha to changes in liver phenotypes induced by TFA, two diets were used: a purified control diet and an isocaloric diet in which most of the soybean oil, a major source of FA in the diet, was replaced with TFA-rich shortening. The diets were fed to wild-type and Ppara-null mice for 2 months. Ppara-null mice fed a TFA-containing diet showed more severe hepatic steatosis and liver damage compared with similarly treated wild-type mice, as revealed by increased hepatic triglyceride (TG) contents and serum alanine aminotransferase activities. While the TFA-rich diet increased the hepatic expression of enzymes involved in de novo FA synthesis and decreased TG-hydrolyzing enzymes in both genotypes, the expression of FA-catabolizing enzymes was decreased in Ppara-null mice, resulting in more severe hepatosteatosis. Additionally, the expression levels of key contributors to inflammation, such as osteopontin, were increased, and nuclear factor-kappa B was activated in TFA-containing diet-fed Ppara-null mice. Enhanced inflammatory signaling in these mice was presumably mediated by toll-like receptor 2, with no accompanying inflammasome activation. Collectively, these results suggest a protective role for PPARa. in the pathological changes in the liver following TFA consumption. PPAR alpha might prevent TFA-containing diet-induced steatohepatitis. (C) 2016 Elsevier Inc. All rights reserved."}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "\u80e1, \u6681"}], "nameIdentifiers": [{"nameIdentifier": "108055", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-06-13"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "14MH282C_yoshi.pdf", "filesize": [{"value": "128.7 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 128699.99999999999, "url": {"label": "\u5185\u5bb9\u306e\u8981\u65e8", "url": "https://soar-ir.repo.nii.ac.jp/record/20719/files/14MH282C_yoshi.pdf"}, "version_id": "f7341f5c-72a8-4c23-86c3-c4d9848f541d"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-06-13"}], "displaytype": "detail", "download_preview_message": "", "file_order": 1, "filename": "14MH282C_shinsa.pdf", "filesize": [{"value": "118.4 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 118400.0, "url": {"label": "\u5be9\u67fb\u7d50\u679c\u306e\u8981\u65e8", "url": "https://soar-ir.repo.nii.ac.jp/record/20719/files/14MH282C_shinsa.pdf"}, "version_id": "aa2800a8-8fa4-46f0-a57d-1187871bb8ee"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-06-13"}], "displaytype": "detail", "download_preview_message": "", "file_order": 2, "filename": "14MH282C_ronbun.pdf", "filesize": [{"value": "727.1 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_11", "mimetype": "application/pdf", "size": 727100.0, "url": {"label": "\u535a\u58eb\u8ad6\u6587\u306e\u5168\u6587", "url": "https://soar-ir.repo.nii.ac.jp/record/20719/files/14MH282C_ronbun.pdf"}, "version_id": "4e93974f-c507-432d-b680-5e74688cb548"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "thesis", "resourceuri": "http://purl.org/coar/resource_type/c_46ec"}]}, "item_title": "PPAR\u03b1 protects against trans-fatty-acid-containing diet-induced steatohepatitis\uff08PPAR\u03b1\u306f\u30c8\u30e9\u30f3\u30b9\u8102\u80aa\u9178\u542b\u6709\u98df\u8a98\u767a\u6027\u8102\u80aa\u6027\u809d\u708e\u306b\u5bfe\u3057\u4fdd\u8b77\u7684\u306b\u4f5c\u7528\u3059\u308b\uff09", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "PPAR\u03b1 protects against trans-fatty-acid-containing diet-induced steatohepatitis\uff08PPAR\u03b1\u306f\u30c8\u30e9\u30f3\u30b9\u8102\u80aa\u9178\u542b\u6709\u98df\u8a98\u767a\u6027\u8102\u80aa\u6027\u809d\u708e\u306b\u5bfe\u3057\u4fdd\u8b77\u7684\u306b\u4f5c\u7528\u3059\u308b\uff09"}]}, "item_type_id": "14", "owner": "1", "path": ["461/848/849"], "permalink_uri": "http://hdl.handle.net/10091/00021477", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_name_i18n": "\u516c\u958b\u65e5", "attribute_value": "2019-06-14"}, "publish_date": "2019-06-14", "publish_status": "0", "recid": "20719", "relation": {}, "relation_version_is_last": true, "title": ["PPAR\u03b1 protects against trans-fatty-acid-containing diet-induced steatohepatitis\uff08PPAR\u03b1\u306f\u30c8\u30e9\u30f3\u30b9\u8102\u80aa\u9178\u542b\u6709\u98df\u8a98\u767a\u6027\u8102\u80aa\u6027\u809d\u708e\u306b\u5bfe\u3057\u4fdd\u8b77\u7684\u306b\u4f5c\u7528\u3059\u308b\uff09"], "weko_shared_id": 3}