WEKO3
アイテム
{"_buckets": {"deposit": "83889f13-6359-4ff7-bbf6-e103a39cf4da"}, "_deposit": {"id": "20736", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "20736"}, "status": "published"}, "_oai": {"id": "oai:soar-ir.repo.nii.ac.jp:00020736", "sets": []}, "author_link": ["108072"], "item_14_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2019-03-31", "bibliographicIssueDateType": "Issued"}}]}, "item_14_date_granted_8": {"attribute_name": "学位授与年月日", "attribute_value_mlt": [{"subitem_dategranted": "2019-03-31"}]}, "item_14_degree_grantor_10": {"attribute_name": "学位授与機関", "attribute_value_mlt": [{"subitem_degreegrantor": [{"subitem_degreegrantor_name": "信州大学(Shinshu university)"}], "subitem_degreegrantor_identifier": [{"subitem_degreegrantor_identifier_name": "13601", "subitem_degreegrantor_identifier_scheme": "kakenhi"}]}]}, "item_14_degree_name_9": {"attribute_name": "学位名", "attribute_value_mlt": [{"subitem_degreename": "博士(医学)"}]}, "item_14_description_26": {"attribute_name": "内容記述", "attribute_value_mlt": [{"subitem_description": "雑誌に発表。SCIENTIFIC REPORTS. 7:46705 (2017); doi:10.1038/srep46705.", "subitem_description_type": "Other"}]}, "item_14_description_37": {"attribute_name": "資源タイプ(コンテンツの種類)", "attribute_value_mlt": [{"subitem_description": "Thesis", "subitem_description_type": "Other"}]}, "item_14_description_5": {"attribute_name": "引用", "attribute_value_mlt": [{"subitem_description": "山崎 智生. Association of Serum Autotaxin Levels with Liver Fibrosis in Patients with Chronic Hepatitis C(C型慢性肝炎患者における血清Autotaxinの肝線維化マーカーとしての有用性). 信州大学, 2019, 博士論文.", "subitem_description_type": "Other"}]}, "item_14_dissertation_number_7": {"attribute_name": "学位授与番号", "attribute_value_mlt": [{"subitem_dissertationnumber": "13601甲第1153号"}]}, "item_14_link_74": {"attribute_name": "WoS", "attribute_value_mlt": [{"subitem_link_text": "Web of Science", "subitem_link_url": "http://gateway.isiknowledge.com/gateway/Gateway.cgi?\u0026GWVersion=2\u0026SrcAuth=ShinshuUniv\u0026SrcApp=ShinshuUniv\u0026DestLinkType=FullRecord\u0026DestApp=WOS\u0026KeyUT=000425902600001"}]}, "item_14_publisher_4": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "信州大学"}]}, "item_14_relation_54": {"attribute_name": "PubMed", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "28425454"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://pubmed.ncbi.nlm.nih.gov/28425454/", "subitem_relation_type_select": "PMID"}}]}, "item_14_relation_55": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "10.1038/srep46705"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1038/srep46705", "subitem_relation_type_select": "DOI"}}]}, "item_14_rights_69": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/"}]}, "item_14_select_71": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "ETD"}]}, "item_14_text_11": {"attribute_name": "学位の区分", "attribute_value_mlt": [{"subitem_text_value": "doctoral"}]}, "item_14_text_12": {"attribute_name": "学位の分野", "attribute_value_mlt": [{"subitem_text_value": "医学"}]}, "item_14_text_13": {"attribute_name": "学位の報告番号", "attribute_value_mlt": [{"subitem_text_value": "甲第1153号"}]}, "item_14_text_77": {"attribute_name": "wosonly keywords", "attribute_value_mlt": [{"subitem_text_value": "SIMPLE NONINVASIVE INDEX; LYSOPHOSPHATIDIC ACID; LYSOPHOSPHOLIPASE-D; ANTIVIRAL THERAPY; JAPANESE PATIENTS; STELLATE CELLS; IDENTIFICATION; COMBINATION; RECEPTORS; RIBAVIRIN"}]}, "item_14_textarea_75": {"attribute_name": "wosonly abstract", "attribute_value_mlt": [{"subitem_textarea_value": "Metabolized by liver sinusoidal endothelial cells, autotaxin (ATX) is a secreted enzyme considered to be associated with liver damage. We sought to clarify the diagnostic ability of ATX for liver fibrosis in 593 biopsy-confirmed hepatitis C virus (HCV)-infected patients. The diagnostic accuracy of ATX was compared with clinical parameters and the established fibrosis biomarkers Wisteria floribunda agglutinin-positive Mac-2-binding protein, FIB-4 index, AST-to-platelet ratio, and Forn\u0027s index. Median ATX levels were consistently higher in female controls and patients than in their male counterparts (P \u003c 0.01). Serum ATX concentration increased significantly according to liver fibrosis stage in overall and both genders (P \u003c 0.001). The cutoff values of ATX for prediction of fibrosis stages \u003e= F1, \u003e= F2, \u003e= F3, and F4 were 0.8, 1.1, 1.3, and 1.7 mg/L, respectively, in male patients and 0.9, 1.7, 1.8, and 2.0 mg/L, respectively, in female patients. The area under the receiver operating characteristic curve for ATX to diagnose fibrosis of \u003e= F2 (0.861) in male patients was superior to those of FIB-4 index and Forn\u0027s index (P \u003c 0.001), while that in female patients (0.801) was comparable with those of the other markers. ATX therefore represents a novel non-invasive biomarker for liver fibrosis in HCV-infected patients."}]}, "item_1627890986942": {"attribute_name": "出版タイプ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_be7fb7dd8ff6fe43", "subitem_version_type": "NA"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "open access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_abf2"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "山崎, 智生", "creatorNameLang": "ja"}], "nameIdentifiers": [{"nameIdentifier": "108072", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-06-13"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "15MH040J_yoshi.pdf", "filesize": [{"value": "110.0 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 110000.0, "url": {"label": "内容の要旨", "url": "https://soar-ir.repo.nii.ac.jp/record/20736/files/15MH040J_yoshi.pdf"}, "version_id": "d8d00d96-d66b-4aee-8679-b552c6df5428"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-06-13"}], "displaytype": "detail", "download_preview_message": "", "file_order": 1, "filename": "15MH040J_shinsa.pdf", "filesize": [{"value": "107.2 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 107200.0, "url": {"label": "審査結果の要旨", "url": "https://soar-ir.repo.nii.ac.jp/record/20736/files/15MH040J_shinsa.pdf"}, "version_id": "09e2cbd6-5229-4983-8d54-ac7a79932588"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-06-13"}], "displaytype": "detail", "download_preview_message": "", "file_order": 2, "filename": "15MH040J_ronbun.pdf", "filesize": [{"value": "1.0 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_6", "mimetype": "application/pdf", "size": 1000000.0, "url": {"label": "博士論文の全文", "objectType": "fulltext", "url": "https://soar-ir.repo.nii.ac.jp/record/20736/files/15MH040J_ronbun.pdf"}, "version_id": "66cc625c-e605-4714-b6ac-92dc0aded139"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "doctoral thesis", "resourceuri": "http://purl.org/coar/resource_type/c_db06"}]}, "item_title": "Association of Serum Autotaxin Levels with Liver Fibrosis in Patients with Chronic Hepatitis C(C型慢性肝炎患者における血清Autotaxinの肝線維化マーカーとしての有用性)", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Association of Serum Autotaxin Levels with Liver Fibrosis in Patients with Chronic Hepatitis C(C型慢性肝炎患者における血清Autotaxinの肝線維化マーカーとしての有用性)", "subitem_title_language": "en"}]}, "item_type_id": "14", "owner": "1", "path": ["849"], "permalink_uri": "http://hdl.handle.net/10091/00021494", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2019-06-14"}, "publish_date": "2019-06-14", "publish_status": "0", "recid": "20736", "relation": {}, "relation_version_is_last": true, "title": ["Association of Serum Autotaxin Levels with Liver Fibrosis in Patients with Chronic Hepatitis C(C型慢性肝炎患者における血清Autotaxinの肝線維化マーカーとしての有用性)"], "weko_shared_id": -1}
Association of Serum Autotaxin Levels with Liver Fibrosis in Patients with Chronic Hepatitis C(C型慢性肝炎患者における血清Autotaxinの肝線維化マーカーとしての有用性)
http://hdl.handle.net/10091/00021494
http://hdl.handle.net/10091/000214945e3d5dd6-068b-4671-af5d-74f15ad35ded
名前 / ファイル | ライセンス | アクション |
---|---|---|
内容の要旨 (110.0 kB)
|
|
|
審査結果の要旨 (107.2 kB)
|
|
|
博士論文の全文 (1.0 MB)
|
Item type | 学位論文 / Thesis or Dissertation(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2019-06-14 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Association of Serum Autotaxin Levels with Liver Fibrosis in Patients with Chronic Hepatitis C(C型慢性肝炎患者における血清Autotaxinの肝線維化マーカーとしての有用性) | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_db06 | |||||
タイプ | doctoral thesis | |||||
アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
著者 |
山崎, 智生
× 山崎, 智生 |
|||||
出版者 | ||||||
出版者 | 信州大学 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 山崎 智生. Association of Serum Autotaxin Levels with Liver Fibrosis in Patients with Chronic Hepatitis C(C型慢性肝炎患者における血清Autotaxinの肝線維化マーカーとしての有用性). 信州大学, 2019, 博士論文. | |||||
書誌情報 |
発行日 2019-03-31 |
|||||
学位授与番号 | ||||||
学位授与番号 | 13601甲第1153号 | |||||
学位授与年月日 | ||||||
学位授与年月日 | 2019-03-31 | |||||
学位名 | ||||||
学位名 | 博士(医学) | |||||
学位授与機関 | ||||||
学位授与機関識別子Scheme | kakenhi | |||||
学位授与機関識別子 | 13601 | |||||
学位授与機関名 | 信州大学(Shinshu university) | |||||
学位の区分 | ||||||
doctoral | ||||||
学位の分野 | ||||||
医学 | ||||||
学位の報告番号 | ||||||
甲第1153号 | ||||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 雑誌に発表。SCIENTIFIC REPORTS. 7:46705 (2017); doi:10.1038/srep46705. | |||||
資源タイプ(コンテンツの種類) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Thesis | |||||
PubMed | ||||||
識別子タイプ | PMID | |||||
関連識別子 | https://pubmed.ncbi.nlm.nih.gov/28425454/ | |||||
関連名称 | 28425454 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1038/srep46705 | |||||
関連名称 | 10.1038/srep46705 | |||||
権利 | ||||||
権利情報 | This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ | |||||
出版タイプ | ||||||
出版タイプ | NA | |||||
出版タイプResource | http://purl.org/coar/version/c_be7fb7dd8ff6fe43 | |||||
WoS | ||||||
Web of Science | ||||||
URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000425902600001 |