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Association of Serum Autotaxin Levels with Liver Fibrosis in Patients with Chronic Hepatitis C\uff08C\u578b\u6162\u6027\u809d\u708e\u60a3\u8005\u306b\u304a\u3051\u308b\u8840\u6e05Autotaxin\u306e\u809d\u7dda\u7dad\u5316\u30de\u30fc\u30ab\u30fc\u3068\u3057\u3066\u306e\u6709\u7528\u6027\uff09. \u4fe1\u5dde\u5927\u5b66, 2019, \u535a\u58eb\u8ad6\u6587.", "subitem_description_type": "Other"}]}, "item_14_dissertation_number_7": {"attribute_name": "\u5b66\u4f4d\u6388\u4e0e\u756a\u53f7", "attribute_value_mlt": [{"subitem_dissertationnumber": "13601\u7532\u7b2c1153\u53f7"}]}, "item_14_link_74": {"attribute_name": "WoS", "attribute_value_mlt": [{"subitem_link_text": "Web of Science", "subitem_link_url": "http://gateway.isiknowledge.com/gateway/Gateway.cgi?\u0026GWVersion=2\u0026SrcAuth=ShinshuUniv\u0026SrcApp=ShinshuUniv\u0026DestLinkType=FullRecord\u0026DestApp=WOS\u0026KeyUT=000425902600001"}]}, "item_14_publisher_4": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "\u4fe1\u5dde\u5927\u5b66"}]}, "item_14_relation_54": {"attribute_name": "PubMed", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "28425454"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search\u0026DB=pubmed\u0026term=28425454", "subitem_relation_type_select": "PMID"}}]}, "item_14_relation_55": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "10.1038/srep46705"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1038/srep46705", "subitem_relation_type_select": "DOI"}}]}, "item_14_rights_69": {"attribute_name": "\u6a29\u5229", "attribute_value_mlt": [{"subitem_rights": "This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article\u2019s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/"}]}, "item_14_select_71": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "ETD"}]}, "item_14_text_11": {"attribute_name": "\u5b66\u4f4d\u306e\u533a\u5206", "attribute_value_mlt": [{"subitem_text_value": "Doctoral"}]}, "item_14_text_12": {"attribute_name": "\u5b66\u4f4d\u306e\u5206\u91ce", "attribute_value_mlt": [{"subitem_text_value": "\u533b\u5b66"}]}, "item_14_text_13": {"attribute_name": "\u5b66\u4f4d\u306e\u5831\u544a\u756a\u53f7", "attribute_value_mlt": [{"subitem_text_value": "\u7532\u7b2c1153\u53f7"}]}, "item_14_text_77": {"attribute_name": "wosonly keywords", "attribute_value_mlt": [{"subitem_text_value": "SIMPLE NONINVASIVE INDEX; LYSOPHOSPHATIDIC ACID; LYSOPHOSPHOLIPASE-D; ANTIVIRAL THERAPY; JAPANESE PATIENTS; STELLATE CELLS; IDENTIFICATION; COMBINATION; RECEPTORS; RIBAVIRIN"}]}, "item_14_textarea_75": {"attribute_name": "wosonly abstract", "attribute_value_mlt": [{"subitem_textarea_value": "Metabolized by liver sinusoidal endothelial cells, autotaxin (ATX) is a secreted enzyme considered to be associated with liver damage. We sought to clarify the diagnostic ability of ATX for liver fibrosis in 593 biopsy-confirmed hepatitis C virus (HCV)-infected patients. The diagnostic accuracy of ATX was compared with clinical parameters and the established fibrosis biomarkers Wisteria floribunda agglutinin-positive Mac-2-binding protein, FIB-4 index, AST-to-platelet ratio, and Forn\u0027s index. Median ATX levels were consistently higher in female controls and patients than in their male counterparts (P \u003c 0.01). Serum ATX concentration increased significantly according to liver fibrosis stage in overall and both genders (P \u003c 0.001). The cutoff values of ATX for prediction of fibrosis stages \u003e= F1, \u003e= F2, \u003e= F3, and F4 were 0.8, 1.1, 1.3, and 1.7 mg/L, respectively, in male patients and 0.9, 1.7, 1.8, and 2.0 mg/L, respectively, in female patients. The area under the receiver operating characteristic curve for ATX to diagnose fibrosis of \u003e= F2 (0.861) in male patients was superior to those of FIB-4 index and Forn\u0027s index (P \u003c 0.001), while that in female patients (0.801) was comparable with those of the other markers. ATX therefore represents a novel non-invasive biomarker for liver fibrosis in HCV-infected patients."}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "\u5c71\u5d0e, \u667a\u751f"}], "nameIdentifiers": [{"nameIdentifier": "108072", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-06-13"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "15MH040J_yoshi.pdf", "filesize": [{"value": "110.0 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 110000.0, "url": {"label": "\u5185\u5bb9\u306e\u8981\u65e8", "url": "https://soar-ir.repo.nii.ac.jp/record/20736/files/15MH040J_yoshi.pdf"}, "version_id": "d8d00d96-d66b-4aee-8679-b552c6df5428"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-06-13"}], "displaytype": "detail", "download_preview_message": "", "file_order": 1, "filename": "15MH040J_shinsa.pdf", "filesize": [{"value": "107.2 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 107200.0, "url": {"label": "\u5be9\u67fb\u7d50\u679c\u306e\u8981\u65e8", "url": "https://soar-ir.repo.nii.ac.jp/record/20736/files/15MH040J_shinsa.pdf"}, "version_id": "09e2cbd6-5229-4983-8d54-ac7a79932588"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-06-13"}], "displaytype": "detail", "download_preview_message": "", "file_order": 2, "filename": "15MH040J_ronbun.pdf", "filesize": [{"value": "1.0 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_6", "mimetype": "application/pdf", "size": 1000000.0, "url": {"label": "\u535a\u58eb\u8ad6\u6587\u306e\u5168\u6587", "url": "https://soar-ir.repo.nii.ac.jp/record/20736/files/15MH040J_ronbun.pdf"}, "version_id": "66cc625c-e605-4714-b6ac-92dc0aded139"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "thesis", "resourceuri": "http://purl.org/coar/resource_type/c_46ec"}]}, "item_title": "Association of Serum Autotaxin Levels with Liver Fibrosis in Patients with Chronic Hepatitis C\uff08C\u578b\u6162\u6027\u809d\u708e\u60a3\u8005\u306b\u304a\u3051\u308b\u8840\u6e05Autotaxin\u306e\u809d\u7dda\u7dad\u5316\u30de\u30fc\u30ab\u30fc\u3068\u3057\u3066\u306e\u6709\u7528\u6027\uff09", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Association of Serum Autotaxin Levels with Liver Fibrosis in Patients with Chronic Hepatitis C\uff08C\u578b\u6162\u6027\u809d\u708e\u60a3\u8005\u306b\u304a\u3051\u308b\u8840\u6e05Autotaxin\u306e\u809d\u7dda\u7dad\u5316\u30de\u30fc\u30ab\u30fc\u3068\u3057\u3066\u306e\u6709\u7528\u6027\uff09"}]}, "item_type_id": "14", "owner": "1", "path": ["461/848/849"], "permalink_uri": "http://hdl.handle.net/10091/00021494", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_name_i18n": "\u516c\u958b\u65e5", "attribute_value": "2019-06-14"}, "publish_date": "2019-06-14", "publish_status": "0", "recid": "20736", "relation": {}, "relation_version_is_last": true, "title": ["Association of Serum Autotaxin Levels with Liver Fibrosis in Patients with Chronic Hepatitis C\uff08C\u578b\u6162\u6027\u809d\u708e\u60a3\u8005\u306b\u304a\u3051\u308b\u8840\u6e05Autotaxin\u306e\u809d\u7dda\u7dad\u5316\u30de\u30fc\u30ab\u30fc\u3068\u3057\u3066\u306e\u6709\u7528\u6027\uff09"], "weko_shared_id": 3}