{"_buckets": {"deposit": "aaa25d5b-87ef-436d-86f6-5ae0a4c2fdd6"}, "_deposit": {"id": "20741", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "20741"}, "status": "published"}, "_oai": {"id": "oai:soar-ir.repo.nii.ac.jp:00020741", "sets": []}, "author_link": ["108077"], "item_14_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2019-03-31", "bibliographicIssueDateType": "Issued"}}]}, "item_14_date_granted_8": {"attribute_name": "学位授与年月日", "attribute_value_mlt": [{"subitem_dategranted": "2019-03-31"}]}, "item_14_degree_grantor_10": {"attribute_name": "学位授与機関", "attribute_value_mlt": [{"subitem_degreegrantor": [{"subitem_degreegrantor_name": "信州大学(Shinshu university)"}], "subitem_degreegrantor_identifier": [{"subitem_degreegrantor_identifier_name": "13601", "subitem_degreegrantor_identifier_scheme": "kakenhi"}]}]}, "item_14_degree_name_9": {"attribute_name": "学位名", "attribute_value_mlt": [{"subitem_degreename": "博士（医学）"}]}, "item_14_description_26": {"attribute_name": "内容記述", "attribute_value_mlt": [{"subitem_description": "雑誌に発表。AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY. 316(1):G155-G165 (2019); doi:10.1152/ajpgi.00325.2018.", "subitem_description_type": "Other"}]}, "item_14_description_37": {"attribute_name": "資源タイプ（コンテンツの種類）", "attribute_value_mlt": [{"subitem_description": "Thesis", "subitem_description_type": "Other"}]}, "item_14_description_5": {"attribute_name": "引用", "attribute_value_mlt": [{"subitem_description": "長汐　沙千穂. Water intake increases mesenteric lymph flow and the total flux of albumin,long-chain fatty acids, and IL-22 in rats: New concept of absorption in jejunum（水の摂取によりラットの腸管膜リンパ流量とアルブミン，長鎖脂肪酸，IL-22の総量が増加する；空腸における吸収の生理機能の新概念）. 信州大学, 2019, 博士論文.", "subitem_description_type": "Other"}]}, "item_14_dissertation_number_7": {"attribute_name": "学位授与番号", "attribute_value_mlt": [{"subitem_dissertationnumber": "13601甲第1158号"}]}, "item_14_link_74": {"attribute_name": "WoS", "attribute_value_mlt": [{"subitem_link_text": "Web of Science", "subitem_link_url": "http://gateway.isiknowledge.com/gateway/Gateway.cgi?\u0026GWVersion=2\u0026SrcAuth=ShinshuUniv\u0026SrcApp=ShinshuUniv\u0026DestLinkType=FullRecord\u0026DestApp=WOS\u0026KeyUT=000455670700009"}]}, "item_14_publisher_4": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "信州大学"}]}, "item_14_relation_54": {"attribute_name": "PubMed", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "30431330"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://pubmed.ncbi.nlm.nih.gov/30431330/", "subitem_relation_type_select": "PMID"}}]}, "item_14_relation_55": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "10.1152/ajpgi.00325.2018"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1152/ajpgi.00325.2018", "subitem_relation_type_select": "DOI"}}]}, "item_14_rights_69": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "© 2019 the American Physiological Society"}]}, "item_14_select_71": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "ETD"}]}, "item_14_text_11": {"attribute_name": "学位の区分", "attribute_value_mlt": [{"subitem_text_value": "doctoral"}]}, "item_14_text_12": {"attribute_name": "学位の分野", "attribute_value_mlt": [{"subitem_text_value": "医学"}]}, "item_14_text_13": {"attribute_name": "学位の報告番号", "attribute_value_mlt": [{"subitem_text_value": "甲第1158号"}]}, "item_14_text_76": {"attribute_name": "wosonly authkey", "attribute_value_mlt": [{"subitem_text_value": "consumed water; ILC-3; IL-22; long-chain fatty acids; mesenteric lymph"}]}, "item_14_text_77": {"attribute_name": "wosonly keywords", "attribute_value_mlt": [{"subitem_text_value": "CAPILLARY FLUID; PHYSIOLOGY"}]}, "item_14_textarea_75": {"attribute_name": "wosonly abstract", "attribute_value_mlt": [{"subitem_textarea_value": "The traditional Japanese health care custom recommends that a suitable volume of water is consumed. However, physiological and immunological mechanisms in support of this practice are unknown. Therefore, we conducted rat and rabbit in vivo experiments to investigate the effects of intragastric administration of distilled water on the jejunal-originated lymph flow and the concentrations and total flux of cells, albumin, long-chain fatty acids, and innate lymphoid cell 3 (ILC-3)-secreted interleukin-22 (IL-22) through mesenteric lymph vessels. The distribution and activity of ILC-3 in rat small intestine by water intake were evaluated using flow cytometry and RT-PCR. The intragastric administration of distilled water caused significant increases in rat mesenteric lymph flow and in the total flux of cells, albumin, long-chain fatty acids, and IL-22 through the lymph vessels. Intravenously injected Evans blue dye was rapidly transported into rabbit mesenteric lymph vessel and cisterna chyli. The distribution of ILC-3 and the expression of IL-22 mRNA were maximal in the lamina propria cells of the rat jejunum. No significant presence of ILC-3 in the lymph was observed in the control and under water intake conditions. In conclusion, the absorbed water in the jejunum is transported through mesenteric lymph vessels. The higher permeability of albumin in the jejunal microcirculation may play key roles in the transport of consumed water and the reservoir and transporter of long-chain fatty acids. Water intake also accelerates the transfer of IL-22 to the mesenteric lymph, which may contribute, in part, to maintaining and promoting the innate immunity in the body. NEW \u0026 NOTEWORTHY The higher permeability of album-inmediated transport of water-soluble substances in mesenteric lymph vessels of the jejunum may have a large impact on the classic concept suggesting that water-soluble small molecules travel to the liver via the portal vein. ILC-3 is mainly housed in the lamina propria of the jejunum, especially its upper part. IL-22 released from the ILC-3 is also transported through mesenteric lymph in collaboration with the albumin-mediated movement of consumed water."}]}, "item_1627890986942": {"attribute_name": "出版タイプ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_be7fb7dd8ff6fe43", "subitem_version_type": "NA"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "open access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_abf2"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "長汐, 沙千穂", "creatorNameLang": "ja"}], "nameIdentifiers": [{"nameIdentifier": "108077", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-06-14"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "16MH024A_yoshi.pdf", "filesize": [{"value": "139.1 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 139100.0, "url": {"label": "内容の要旨", "url": "https://soar-ir.repo.nii.ac.jp/record/20741/files/16MH024A_yoshi.pdf"}, "version_id": "86e2df99-2215-407a-a375-4784b13a64a6"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-06-14"}], "displaytype": "detail", "download_preview_message": "", "file_order": 1, "filename": "16MH024A_shinsa.pdf", "filesize": [{"value": "104.4 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 104400.0, "url": {"label": "審査結果の要旨", "url": "https://soar-ir.repo.nii.ac.jp/record/20741/files/16MH024A_shinsa.pdf"}, "version_id": "c324ea04-91a0-44ef-a187-7e544951137b"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-02-02"}], "displaytype": "detail", "download_preview_message": "", "file_order": 2, "filename": "16MH024A_ronbun.pdf", "filesize": [{"value": "3.2 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensefree": "© 2019 the American Physiological Society", "licensetype": "license_note", "mimetype": "application/pdf", "size": 3200000.0, "url": {"label": "博士論文の全文", "objectType": "fulltext", "url": "https://soar-ir.repo.nii.ac.jp/record/20741/files/16MH024A_ronbun.pdf"}, "version_id": "622eae61-e158-46fa-b666-6ee4a6a229a3"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "doctoral thesis", "resourceuri": "http://purl.org/coar/resource_type/c_db06"}]}, "item_title": "Water intake increases mesenteric lymph flow and the total flux of albumin,long-chain fatty acids, and IL-22 in rats: New concept of absorption in jejunum（水の摂取によりラットの腸管膜リンパ流量とアルブミン，長鎖脂肪酸，IL-22の総量が増加する；空腸における吸収の生理機能の新概念）", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Water intake increases mesenteric lymph flow and the total flux of albumin,long-chain fatty acids, and IL-22 in rats: New concept of absorption in jejunum（水の摂取によりラットの腸管膜リンパ流量とアルブミン，長鎖脂肪酸，IL-22の総量が増加する；空腸における吸収の生理機能の新概念）", "subitem_title_language": "en"}]}, "item_type_id": "14", "owner": "1", "path": ["849"], "permalink_uri": "http://hdl.handle.net/10091/00021499", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2019-06-14"}, "publish_date": "2019-06-14", "publish_status": "0", "recid": "20741", "relation": {}, "relation_version_is_last": true, "title": ["Water intake increases mesenteric lymph flow and the total flux of albumin,long-chain fatty acids, and IL-22 in rats: New concept of absorption in jejunum（水の摂取によりラットの腸管膜リンパ流量とアルブミン，長鎖脂肪酸，IL-22の総量が増加する；空腸における吸収の生理機能の新概念）"], "weko_shared_id": -1}