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Here, the aim is to study the reconstructive knowledge gap following expanded-EEA and to introduce the watertight robust osteoconductive (WRO)-barrier as an alternative durable option. Distinctively, we focused on 10 clinical circumstances. A 3D-skull base-water system model was innovated to investigate the ESBR under realistic conditions. A large-irregular defect (31 x 89 mm) extending from the crista galli to the mid-clivus was achieved. Then, WRO-barrier was fashioned and its tolerance was evaluated under stressful settings, including an exceedingly high (55 cmH(2)O) pressure, with radiological assessment. Next, the whole WRO-barrier was drilled to examine its practical-safe removal (simulating redo-EEA) and the whole experiment was repeated. Finally, WRO-barrier was kept into place to value its 18-month long-term high-tolerance. Results in all experiments of WRO-barriers were satisfactorily fashioned to conform the geometry of the created defect under realistic circumstances via EEA, tolerated an exceedingly high pressure without evidence of leak even under stressful settings, resisted sudden-elevated pressure, and remained in its position to maintain long-term watertight seal (18 months), efficiently evaluated with neuroimaging and simply removed-and-reconstructed when redo-EEA is needed. 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  1. 050 医学部, 大学院医学系研究科
  2. 0507 学位論文
  3. 博士(医学)

Watertight Robust Osteoconductive Barrier For Complex Skull Base Reconstruction: An Expanded-Endoscopic Endonasal Experimental Study.(WROバリヤー:広範頭蓋底腫瘍に対する経鼻内視鏡手術における新たな頭蓋底再建法)

http://hdl.handle.net/10091/00021502
31fe1b24-5b0c-454c-8e2c-cef5fa5cdf00
名前 / ファイル ライセンス アクション
15MH030A_yoshi.pdf 内容の要旨 (132.8 kB)
15MH030A_shinsa.pdf 審査結果の要旨 (108.6 kB)
15MH030A_ronbun.pdf 博士論文の全文 (2.7 MB)
license.icon
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2019-06-14
タイトル
言語 en
タイトル Watertight Robust Osteoconductive Barrier For Complex Skull Base Reconstruction: An Expanded-Endoscopic Endonasal Experimental Study.(WROバリヤー:広範頭蓋底腫瘍に対する経鼻内視鏡手術における新たな頭蓋底再建法)
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_db06
タイプ doctoral thesis
著者 NAGM, ALHUSAIN

× NAGM, ALHUSAIN

WEKO 108080

NAGM, ALHUSAIN

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出版者
出版者 信州大学
引用
内容記述タイプ Other
内容記述 NAGM ALHUSAIN. Watertight Robust Osteoconductive Barrier For Complex Skull Base Reconstruction: An Expanded-Endoscopic Endonasal Experimental Study.(WROバリヤー:広範頭蓋底腫瘍に対する経鼻内視鏡手術における新たな頭蓋底再建法). 信州大学, 2019, 博士論文.
書誌情報
発行日 2019-03-31
学位授与番号
学位授与番号 13601甲第1161号
学位授与年月日
学位授与年月日 2019-03-31
学位名
学位名 博士(医学)
学位授与機関
学位授与機関名
学位授与機関名 信州大学(Shinshu university)
学位の区分
Doctoral
学位の分野
医学
学位の報告番号
甲第1161号
内容記述
内容記述タイプ Other
内容記述 雑誌に発表。NEUROLOGIA MEDICO-CHIRURGICA. 59(3):79-88 (2019); doi:10.2176/nmc.oa.2018-0262.
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Thesis
PubMed
関連識別子
識別子タイプ PMID
関連識別子 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search&DB=pubmed&term=30787233
関連名称
関連名称 30787233
DOI
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.2176/nmc.oa.2018-0262
関連名称
関連名称 10.2176/nmc.oa.2018-0262
権利
権利情報 © 2019 by The Japan Neurosurgical Society / This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives International License.
出版タイプ
出版タイプ NA
出版タイプResource http://purl.org/coar/version/c_be7fb7dd8ff6fe43
WoS
Web of Science
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000462817600002
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